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249 related items for PubMed ID: 12196556

  • 1. No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.
    Kniazeff J, Galvez T, Labesse G, Pin JP.
    J Neurosci; 2002 Sep 01; 22(17):7352-61. PubMed ID: 12196556
    [Abstract] [Full Text] [Related]

  • 2. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.
    Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prézeau L.
    J Biol Chem; 2002 Feb 01; 277(5):3236-41. PubMed ID: 11711539
    [Abstract] [Full Text] [Related]

  • 3. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function.
    Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L, Pin JP.
    EMBO J; 2001 May 01; 20(9):2152-9. PubMed ID: 11331581
    [Abstract] [Full Text] [Related]

  • 4. The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.
    Havlickova M, Prezeau L, Duthey B, Bettler B, Pin JP, Blahos J.
    Mol Pharmacol; 2002 Aug 01; 62(2):343-50. PubMed ID: 12130687
    [Abstract] [Full Text] [Related]

  • 5. Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.
    Liu J, Maurel D, Etzol S, Brabet I, Ansanay H, Pin JP, Rondard P.
    J Biol Chem; 2004 Apr 16; 279(16):15824-30. PubMed ID: 14736871
    [Abstract] [Full Text] [Related]

  • 6. Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
    Margeta-Mitrovic M, Jan YN, Jan LY.
    Proc Natl Acad Sci U S A; 2001 Dec 04; 98(25):14643-8. PubMed ID: 11724957
    [Abstract] [Full Text] [Related]

  • 7. Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.
    Dupuis DS, Relkovic D, Lhuillier L, Mosbacher J, Kaupmann K.
    Mol Pharmacol; 2006 Dec 04; 70(6):2027-36. PubMed ID: 16966477
    [Abstract] [Full Text] [Related]

  • 8. Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.
    Margeta-Mitrovic M, Jan YN, Jan LY.
    Proc Natl Acad Sci U S A; 2001 Dec 04; 98(25):14649-54. PubMed ID: 11724956
    [Abstract] [Full Text] [Related]

  • 9. Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
    Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY.
    J Pharmacol Exp Ther; 2000 May 04; 293(2):460-7. PubMed ID: 10773016
    [Abstract] [Full Text] [Related]

  • 10. Distribution of the GABA(B) receptor subunit gb2 in rat CNS.
    Clark JA, Mezey E, Lam AS, Bonner TI.
    Brain Res; 2000 Mar 31; 860(1-2):41-52. PubMed ID: 10727622
    [Abstract] [Full Text] [Related]

  • 11. A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits.
    Sun B, Chen L, Liu L, Xia Z, Pin JP, Nan F, Liu J.
    Biochem J; 2016 Mar 15; 473(6):779-87. PubMed ID: 26772870
    [Abstract] [Full Text] [Related]

  • 12. Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.
    Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, Smith A, McKernan R, Metters K, O'Neill GP, Lacaille JC, Hébert TE.
    Mol Pharmacol; 2001 Jan 15; 59(1):144-52. PubMed ID: 11125035
    [Abstract] [Full Text] [Related]

  • 13. Structural basis of the activation of a metabotropic GABA receptor.
    Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V.
    Nature; 2020 Aug 15; 584(7820):298-303. PubMed ID: 32555460
    [Abstract] [Full Text] [Related]

  • 14. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Baloucoune GA, Chun L, Zhang W, Xu C, Huang S, Sun Q, Wang Y, Tu H, Liu J.
    PLoS One; 2012 Aug 15; 7(6):e39698. PubMed ID: 22761875
    [Abstract] [Full Text] [Related]

  • 15. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.
    Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L.
    J Biol Chem; 2004 Jul 09; 279(28):29085-91. PubMed ID: 15126507
    [Abstract] [Full Text] [Related]

  • 16. Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.
    Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP.
    J Biol Chem; 1999 Mar 19; 274(12):7607-10. PubMed ID: 10075644
    [Abstract] [Full Text] [Related]

  • 17. Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells.
    González-Maeso J, Wise A, Green A, Koenig JA.
    Eur J Pharmacol; 2003 Nov 14; 481(1):15-23. PubMed ID: 14637170
    [Abstract] [Full Text] [Related]

  • 18. GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper.
    Doly S, Shirvani H, Gäta G, Meye FJ, Emerit MB, Enslen H, Achour L, Pardo-Lopez L, Yang SK, Armand V, Gardette R, Giros B, Gassmann M, Bettler B, Mameli M, Darmon M, Marullo S.
    Mol Psychiatry; 2016 Apr 14; 21(4):480-90. PubMed ID: 26033241
    [Abstract] [Full Text] [Related]

  • 19. Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.
    Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu J.
    EMBO J; 2008 May 07; 27(9):1321-32. PubMed ID: 18388862
    [Abstract] [Full Text] [Related]

  • 20. Activation mechanism of the heterodimeric GABA(B) receptor.
    Pin JP, Kniazeff J, Binet V, Liu J, Maurel D, Galvez T, Duthey B, Havlickova M, Blahos J, Prézeau L, Rondard P.
    Biochem Pharmacol; 2004 Oct 15; 68(8):1565-72. PubMed ID: 15451400
    [Abstract] [Full Text] [Related]

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