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851 related items for PubMed ID: 12208743

  • 1. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.
    Kandasamy K, Srivastava RK.
    Cancer Res; 2002 Sep 01; 62(17):4929-37. PubMed ID: 12208743
    [Abstract] [Full Text] [Related]

  • 2. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.
    Chen X, Thakkar H, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    Oncogene; 2001 Sep 20; 20(42):6073-83. PubMed ID: 11593415
    [Abstract] [Full Text] [Related]

  • 3. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.
    Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    J Biol Chem; 2001 Oct 19; 276(42):38361-9. PubMed ID: 11461904
    [Abstract] [Full Text] [Related]

  • 4. Galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells.
    Oka N, Nakahara S, Takenaka Y, Fukumori T, Hogan V, Kanayama HO, Yanagawa T, Raz A.
    Cancer Res; 2005 Sep 01; 65(17):7546-53. PubMed ID: 16140916
    [Abstract] [Full Text] [Related]

  • 5. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor.
    Whang YE, Yuan XJ, Liu Y, Majumder S, Lewis TD.
    Vitam Horm; 2004 Sep 01; 67():409-26. PubMed ID: 15110188
    [Abstract] [Full Text] [Related]

  • 6. Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.
    Rokhlin OW, Guseva NV, Tagiyev AF, Glover RA, Cohen MB.
    Prostate; 2002 Jun 01; 52(1):1-11. PubMed ID: 11992615
    [Abstract] [Full Text] [Related]

  • 7. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
    Brognard J, Clark AS, Ni Y, Dennis PA.
    Cancer Res; 2001 May 15; 61(10):3986-97. PubMed ID: 11358816
    [Abstract] [Full Text] [Related]

  • 8. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
    Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK.
    Cancer Res; 2003 Apr 01; 63(7):1712-21. PubMed ID: 12670926
    [Abstract] [Full Text] [Related]

  • 9. TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2.
    Alladina SJ, Song JH, Davidge ST, Hao C, Easton AS.
    J Vasc Res; 2005 Apr 01; 42(4):337-47. PubMed ID: 15985761
    [Abstract] [Full Text] [Related]

  • 10. Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase.
    Cenni V, Maraldi NM, Ruggeri A, Secchiero P, Del Coco R, De Pol A, Cocco L, Marmiroli S.
    Int J Oncol; 2004 Dec 01; 25(6):1599-608. PubMed ID: 15547696
    [Abstract] [Full Text] [Related]

  • 11. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.
    Martelli AM, Tazzari PL, Tabellini G, Bortul R, Billi AM, Manzoli L, Ruggeri A, Conte R, Cocco L.
    Leukemia; 2003 Sep 01; 17(9):1794-805. PubMed ID: 12970779
    [Abstract] [Full Text] [Related]

  • 12. Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells.
    Okhrimenko H, Lu W, Xiang C, Hamburger N, Kazimirsky G, Brodie C.
    Cancer Res; 2005 Aug 15; 65(16):7301-9. PubMed ID: 16103081
    [Abstract] [Full Text] [Related]

  • 13. Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation.
    Kang YC, Kim KM, Lee KS, Namkoong S, Lee SJ, Han JA, Jeoung D, Ha KS, Kwon YG, Kim YM.
    Cell Death Differ; 2004 Dec 15; 11(12):1287-98. PubMed ID: 15297884
    [Abstract] [Full Text] [Related]

  • 14. Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release.
    Gibson EM, Henson ES, Haney N, Villanueva J, Gibson SB.
    Cancer Res; 2002 Jan 15; 62(2):488-96. PubMed ID: 11809700
    [Abstract] [Full Text] [Related]

  • 15. Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation.
    Bortul R, Tazzari PL, Cappellini A, Tabellini G, Billi AM, Bareggi R, Manzoli L, Cocco L, Martelli AM.
    Leukemia; 2003 Feb 15; 17(2):379-89. PubMed ID: 12592338
    [Abstract] [Full Text] [Related]

  • 16. Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis.
    Kim JY, Kim YH, Chang I, Kim S, Pak YK, Oh BH, Yagita H, Jung YK, Oh YJ, Lee MS.
    Oncogene; 2002 May 09; 21(20):3139-48. PubMed ID: 12082629
    [Abstract] [Full Text] [Related]

  • 17. Role of phosphatidylinositol-3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand.
    Oka N, Tanimoto S, Taue R, Nakatsuji H, Kishimoto T, Izaki H, Fukumori T, Takahashi M, Nishitani M, Kanayama HO.
    Cancer Sci; 2006 Oct 09; 97(10):1093-8. PubMed ID: 16984382
    [Abstract] [Full Text] [Related]

  • 18. TNF-related apoptosis-inducing ligand-induced apoptosis of melanoma is associated with changes in mitochondrial membrane potential and perinuclear clustering of mitochondria.
    Thomas WD, Zhang XD, Franco AV, Nguyen T, Hersey P.
    J Immunol; 2000 Nov 15; 165(10):5612-20. PubMed ID: 11067917
    [Abstract] [Full Text] [Related]

  • 19. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
    Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC.
    Oncogene; 2002 Aug 22; 21(37):5673-83. PubMed ID: 12173037
    [Abstract] [Full Text] [Related]

  • 20. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL).
    Rychahou PG, Murillo CA, Evers BM.
    Surgery; 2005 Aug 22; 138(2):391-7. PubMed ID: 16153452
    [Abstract] [Full Text] [Related]

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