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714 related items for PubMed ID: 12210846

  • 1. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
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  • 2. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
    Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.
    Nat Cell Biol; 1999 Dec 15; 1(8):479-85. PubMed ID: 10587643
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  • 4. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 15; 96(5):1322-35. PubMed ID: 16478525
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  • 5. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
    Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.
    Brain Res Mol Brain Res; 2005 Jun 13; 137(1-2):70-6. PubMed ID: 15950763
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  • 6. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 13; 8(2):331-42. PubMed ID: 11300728
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  • 8. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
    Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G.
    Nat Cell Biol; 2000 Dec 13; 2(12):863-70. PubMed ID: 11146649
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  • 9. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 13; 39(6):539-50. PubMed ID: 16620965
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  • 10. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
    Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA.
    Nature; 1998 Oct 15; 395(6703):698-702. PubMed ID: 9790190
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  • 11. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
    Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM.
    J Neurochem; 2006 Sep 15; 98(5):1610-8. PubMed ID: 16923170
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  • 12. Presenilins are not required for A beta 42 production in the early secretory pathway.
    Wilson CA, Doms RW, Zheng H, Lee VM.
    Nat Neurosci; 2002 Sep 15; 5(9):849-55. PubMed ID: 12145638
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  • 14. Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis.
    Yukioka F, Matsuzaki S, Kawamoto K, Koyama Y, Hitomi J, Katayama T, Tohyama M.
    Neurochem Int; 2008 Sep 15; 52(4-5):683-7. PubMed ID: 17942194
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  • 16. Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.
    Culvenor JG, Maher F, Evin G, Malchiodi-Albedi F, Cappai R, Underwood JR, Davis JB, Karran EH, Roberts GW, Beyreuther K, Masters CL.
    J Neurosci Res; 1997 Sep 15; 49(6):719-31. PubMed ID: 9335259
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  • 17. Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Sep 15; 16(3):551-64. PubMed ID: 19276550
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  • 18. Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
    Yang Y, Cook DG.
    Neuroscience; 2004 Sep 15; 124(3):501-5. PubMed ID: 14980721
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  • 19. Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
    Malik B, Currais A, Soriano S.
    J Neurochem; 2008 Jul 15; 106(2):912-6. PubMed ID: 18466334
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  • 20. NF-kappaB activated by ER calcium release inhibits Abeta-mediated expression of CHOP protein: enhancement by AD-linked mutant presenilin 1.
    Schapansky J, Olson K, Van Der Ploeg R, Glazner G.
    Exp Neurol; 2007 Dec 15; 208(2):169-76. PubMed ID: 17927985
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