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983 related items for PubMed ID: 12235254

  • 1. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes.
    Milberg P, Eckardt L, Bruns HJ, Biertz J, Ramtin S, Reinsch N, Fleischer D, Kirchhof P, Fabritz L, Breithardt G, Haverkamp W.
    J Pharmacol Exp Ther; 2002 Oct; 303(1):218-25. PubMed ID: 12235254
    [Abstract] [Full Text] [Related]

  • 2. Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.
    Milberg P, Hilker E, Ramtin S, Cakir Y, Stypmann J, Engelen MA, Mönnig G, Osada N, Breithardt G, Haverkamp W, Eckardt L.
    J Cardiovasc Electrophysiol; 2007 Jun; 18(6):647-54. PubMed ID: 17388913
    [Abstract] [Full Text] [Related]

  • 3. Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3.
    Milberg P, Reinsch N, Osada N, Wasmer K, Mönnig G, Stypmann J, Breithardt G, Haverkamp W, Eckardt L.
    Basic Res Cardiol; 2005 Jul; 100(4):365-71. PubMed ID: 15944809
    [Abstract] [Full Text] [Related]

  • 4. Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes.
    Antzelevitch C, Sun ZQ, Zhang ZQ, Yan GX.
    J Am Coll Cardiol; 1996 Dec; 28(7):1836-48. PubMed ID: 8962574
    [Abstract] [Full Text] [Related]

  • 5. In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.
    Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):229-39. PubMed ID: 17054943
    [Abstract] [Full Text] [Related]

  • 6. Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.
    Eckardt L, Breithardt G, Haverkamp W.
    J Pharmacol Exp Ther; 2002 Jan 28; 300(1):64-71. PubMed ID: 11752098
    [Abstract] [Full Text] [Related]

  • 7. Reduced repolarization reserve due to anthracycline therapy facilitates torsade de pointes induced by IKr blockers.
    Milberg P, Fleischer D, Stypmann J, Osada N, Mönnig G, Engelen MA, Bruch C, Breithardt G, Haverkamp W, Eckardt L.
    Basic Res Cardiol; 2007 Jan 28; 102(1):42-51. PubMed ID: 16817026
    [Abstract] [Full Text] [Related]

  • 8. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.
    Aiba T, Shimizu W, Inagaki M, Noda T, Miyoshi S, Ding WG, Zankov DP, Toyoda F, Matsuura H, Horie M, Sunagawa K.
    J Am Coll Cardiol; 2005 Jan 18; 45(2):300-7. PubMed ID: 15653031
    [Abstract] [Full Text] [Related]

  • 9. Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block.
    Milberg P, Ramtin S, Mönnig G, Osada N, Wasmer K, Breithardt G, Haverkamp W, Eckardt L.
    J Cardiovasc Pharmacol; 2004 Sep 18; 44(3):278-86. PubMed ID: 15475823
    [Abstract] [Full Text] [Related]

  • 10. Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3.
    Milberg P, Reinsch N, Wasmer K, Mönnig G, Stypmann J, Osada N, Breithardt G, Haverkamp W, Eckardt L.
    Cardiovasc Res; 2005 Feb 01; 65(2):397-404. PubMed ID: 15639478
    [Abstract] [Full Text] [Related]

  • 11. Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
    Ellermann C, Sterneberg M, Kochhäuser S, Dechering DG, Fehr M, Eckardt L, Frommeyer G.
    Europace; 2018 Oct 01; 20(10):1699-1706. PubMed ID: 29377987
    [Abstract] [Full Text] [Related]

  • 12. Additive Proarrhythmic Effect of Combined Treatment with QT-Prolonging Agents.
    Frommeyer G, Fischer C, Ellermann C, Dechering DG, Kochhäuser S, Lange PS, Wasmer K, Fehr M, Eckardt L.
    Cardiovasc Toxicol; 2018 Feb 01; 18(1):84-90. PubMed ID: 28612303
    [Abstract] [Full Text] [Related]

  • 13. Electrophysiologic profile of dronedarone on the ventricular level: beneficial effect on postrepolarization refractoriness in the presence of rapid phase 3 repolarization.
    Milberg P, Frommeyer G, Uphaus T, Kaiser D, Osada N, Breithardt G, Eckardt L.
    J Cardiovasc Pharmacol; 2012 Jan 01; 59(1):92-100. PubMed ID: 21964157
    [Abstract] [Full Text] [Related]

  • 14. No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.
    Thomsen MB, Beekman JD, Attevelt NJ, Takahara A, Sugiyama A, Chiba K, Vos MA.
    Br J Pharmacol; 2006 Dec 01; 149(8):1039-48. PubMed ID: 17088870
    [Abstract] [Full Text] [Related]

  • 15. Drug-induced QT-interval prolongation and proarrhythmic risk in the treatment of atrial arrhythmias.
    Shantsila E, Watson T, Lip GY.
    Europace; 2007 Sep 01; 9 Suppl 4():iv37-44. PubMed ID: 17766322
    [Abstract] [Full Text] [Related]

  • 16. TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability).
    Hondeghem LM.
    Novartis Found Symp; 2005 Sep 01; 266():235-44; discussion 244-50. PubMed ID: 16050272
    [Abstract] [Full Text] [Related]

  • 17. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
    Lu HR, Yan GX, Gallacher DJ.
    J Pharmacol Toxicol Methods; 2013 Sep 01; 68(2):250-259. PubMed ID: 23337247
    [Abstract] [Full Text] [Related]

  • 18. A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure.
    Frommeyer G, Milberg P, Witte P, Stypmann J, Koopmann M, Lücke M, Osada N, Breithardt G, Fehr M, Eckardt L.
    Eur J Heart Fail; 2011 Oct 01; 13(10):1060-9. PubMed ID: 21873342
    [Abstract] [Full Text] [Related]

  • 19. Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization.
    Milberg P, Frommeyer G, Kleideiter A, Fischer A, Osada N, Breithardt G, Fehr M, Eckardt L.
    Heart Rhythm; 2011 Sep 01; 8(9):1492-500. PubMed ID: 21459164
    [Abstract] [Full Text] [Related]

  • 20. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011 Sep 01; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

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