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Journal Abstract Search

167 related items for PubMed ID: 12235275

  • 1. (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. II. in vivo characterization.
    Brune ME, Fey TA, Brioni JD, Sullivan JP, Williams M, Carroll WA, Coghlan MJ, Gopalakrishnan M.
    J Pharmacol Exp Ther; 2002 Oct; 303(1):387-94. PubMed ID: 12235275
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  • 3. (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine.
    Fryer RM, Preusser LC, Calzadilla SV, Hu Y, Xu H, Marsh KC, Cox BF, Lin CT, Gopalakrishnan M, Reinhart GA.
    J Cardiovasc Pharmacol; 2004 Aug; 44(2):137-47. PubMed ID: 15243293
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  • 5. Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions.
    Carroll WA, Altenbach RJ, Bai H, Brioni JD, Brune ME, Buckner SA, Cassidy C, Chen Y, Coghlan MJ, Daza AV, Drizin I, Fey TA, Fitzgerald M, Gopalakrishnan M, Gregg RJ, Henry RF, Holladay MW, King LL, Kort ME, Kym PR, Milicic I, Tang R, Turner SC, Whiteaker KL, Yi L, Zhang H, Sullivan JP.
    J Med Chem; 2004 Jun 03; 47(12):3163-79. PubMed ID: 15163196
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  • 6. In vivo evaluation of the potency and bladder-vascular selectivity of the ATP-sensitive potassium channel openers (-)-cromakalim, ZD6169 and WAY-133537 in rats.
    Fabiyi AC, Gopalakrishnan M, Lynch JJ, Brioni JD, Coghlan MJ, Brune ME.
    BJU Int; 2003 Feb 03; 91(3):284-90. PubMed ID: 12581020
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  • 9. Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
    Milicic I, Buckner SA, Daza A, Coghlan M, Fey TA, Brune ME, Gopalakrishnan M.
    Eur J Pharmacol; 2006 Feb 17; 532(1-2):107-14. PubMed ID: 16487510
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  • 10. Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators.
    Buckner SA, Milicic I, Daza AV, Coghlan MJ, Gopalakrishnan M.
    Br J Pharmacol; 2002 Feb 17; 135(3):639-48. PubMed ID: 11834611
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  • 11. Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction.
    Fey TA, Gopalakrishnan M, Strake JG, King LL, Brioni JD, Sullivan JP, Coghlan MJ, Brune ME.
    Neurourol Urodyn; 2003 Feb 17; 22(2):147-55. PubMed ID: 12579633
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  • 12. Zeneca ZD6169 and its analogs from a novel series of anilide tertiary carbinols: in vitro KATP channel opening activity in bladder detrusor.
    Li JH, Yasay GD, Zografos P, Kau ST, Ohnmacht CJ, Russell K, Empfield JR, Brown FJ, Trainor DA, Bonev AD.
    Pharmacology; 1995 Jun 17; 51(1):33-42. PubMed ID: 7568342
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  • 14. Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder.
    Darblade B, Behr-Roussel D, Oger S, Hieble JP, Lebret T, Gorny D, Benoit G, Alexandre L, Giuliano F.
    Urology; 2006 Aug 17; 68(2):442-8. PubMed ID: 16904481
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  • 15. Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones.
    Gilbert AM, Antane MM, Argentieri TM, Butera JA, Francisco GD, Freeden C, Gundersen EG, Graceffa RF, Herbst D, Hirth BH, Lennox JR, McFarlane G, Norton NW, Quagliato D, Sheldon JH, Warga D, Wojdan A, Woods M.
    J Med Chem; 2000 Mar 23; 43(6):1203-14. PubMed ID: 10737753
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  • 16. Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
    Altenbach RJ, Brune ME, Buckner SA, Coghlan MJ, Daza AV, Fabiyi A, Gopalakrishnan M, Henry RF, Khilevich A, Kort ME, Milicic I, Scott VE, Smith JC, Whiteaker KL, Carroll WA.
    J Med Chem; 2006 Nov 16; 49(23):6869-87. PubMed ID: 17154517
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  • 17. Modulation of ATP-sensitive and large-conductance Ca++-activated K+ channels by Zeneca ZD6169 in guinea pig bladder smooth muscle cells.
    Hu S, Kim HS.
    J Pharmacol Exp Ther; 1997 Jan 16; 280(1):38-45. PubMed ID: 8996179
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  • 18. ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder.
    Howe BB, Halterman TJ, Yochim CL, Do ML, Pettinger SJ, Stow RB, Ohnmacht CJ, Russell K, Empfield JR, Trainor DA.
    J Pharmacol Exp Ther; 1995 Aug 16; 274(2):884-90. PubMed ID: 7636752
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  • 19. Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig.
    Heppner TJ, Bonev A, Li JH, Kau ST, Nelson MT.
    Pharmacology; 1996 Sep 16; 53(3):170-9. PubMed ID: 8931102
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  • 20. [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.
    Davis-Taber R, Molinari EJ, Altenbach RJ, Whiteaker KL, Shieh CC, Rotert G, Buckner SA, Malysz J, Milicic I, McDermott JS, Gintant GA, Coghlan MJ, Carroll WA, Scott VE, Gopalakrishnan M.
    Mol Pharmacol; 2003 Jul 16; 64(1):143-53. PubMed ID: 12815170
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