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Journal Abstract Search


135 related items for PubMed ID: 12351459

  • 1. Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.
    't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.
    Diabetes; 2002 Oct; 51(10):3135-8. PubMed ID: 12351459
    [Abstract] [Full Text] [Related]

  • 2. Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.
    Hart LM, Dekker JM, van Haeften TW, Ruige JB, Stehouwer CD, Erkelens DW, Heine RJ, Maassen JA.
    Diabetologia; 2000 Apr; 43(4):515-9. PubMed ID: 10819247
    [Abstract] [Full Text] [Related]

  • 3. Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.
    Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.
    Diabetes; 2009 Aug; 58(8):1869-78. PubMed ID: 19491206
    [Abstract] [Full Text] [Related]

  • 4. Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.
    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.
    Diabetes; 2004 May; 53(5):1360-8. PubMed ID: 15111507
    [Abstract] [Full Text] [Related]

  • 5. Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion.
    Huopio H, Vauhkonen I, Komulainen J, Niskanen L, Otonkoski T, Laakso M.
    Diabetes Care; 2002 Jan; 25(1):101-6. PubMed ID: 11772909
    [Abstract] [Full Text] [Related]

  • 6. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
    Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.
    Diabetes; 2003 Feb; 52(2):568-72. PubMed ID: 12540637
    [Abstract] [Full Text] [Related]

  • 7. Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.
    Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ.
    Diabetes Care; 2001 Mar; 24(3):472-8. PubMed ID: 11289470
    [Abstract] [Full Text] [Related]

  • 8. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells.
    Moritz W, Leech CA, Ferrer J, Habener JF.
    Endocrinology; 2001 Jan; 142(1):129-38. PubMed ID: 11145575
    [Abstract] [Full Text] [Related]

  • 9. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).
    Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC, UK Prospective Diabetes Study (UKPDS 53).
    Diabet Med; 2001 Mar; 18(3):206-12. PubMed ID: 11318841
    [Abstract] [Full Text] [Related]

  • 10. [ATP-sensitive K+ channel].
    Nagashima K.
    Nihon Rinsho; 2002 Jul; 60 Suppl 7():548-52. PubMed ID: 12238096
    [No Abstract] [Full Text] [Related]

  • 11. Effects of single nucleotide polymorphisms in K(ATP) channel genes on type 2 diabetes in a Turkish population.
    Gonen MS, Arikoglu H, Erkoc Kaya D, Ozdemir H, Ipekci SH, Arslan A, Kayis SA, Gogebakan B.
    Arch Med Res; 2012 May; 43(4):317-23. PubMed ID: 22704848
    [Abstract] [Full Text] [Related]

  • 12. Sulfonylurea receptor -1 (SUR1): genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus.
    Reis AF, Velho G.
    Diabetes Metab; 2002 Feb; 28(1):14-9. PubMed ID: 11938023
    [Abstract] [Full Text] [Related]

  • 13. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
    Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D.
    Diabetes; 2007 Feb; 56(2):531-6. PubMed ID: 17259403
    [Abstract] [Full Text] [Related]

  • 14. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.
    Hansen T, Echwald SM, Hansen L, Møller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, Pedersen O.
    Diabetes; 1998 Apr; 47(4):598-605. PubMed ID: 9568693
    [Abstract] [Full Text] [Related]

  • 15. Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses.
    van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ.
    Diabet Med; 2005 May; 22(5):590-8. PubMed ID: 15842514
    [Abstract] [Full Text] [Related]

  • 16. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
    Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.
    J Biol Chem; 2006 Feb 24; 281(8):5246-57. PubMed ID: 16377800
    [Abstract] [Full Text] [Related]

  • 17. Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM.
    Inoue H, Ferrer J, Warren-Perry M, Zhang Y, Millns H, Turner RC, Elbein SC, Hampe CL, Suarez BK, Inagaki N, Seino S, Permutt MA.
    Diabetes; 1997 Mar 24; 46(3):502-7. PubMed ID: 9032109
    [Abstract] [Full Text] [Related]

  • 18. Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?
    Riedel MJ, Boora P, Steckley D, de Vries G, Light PE.
    Diabetes; 2003 Oct 24; 52(10):2630-5. PubMed ID: 14514649
    [Abstract] [Full Text] [Related]

  • 19. Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.
    Remedi MS, Rocheleau JV, Tong A, Patton BL, McDaniel ML, Piston DW, Koster JC, Nichols CG.
    Diabetologia; 2006 Oct 24; 49(10):2368-78. PubMed ID: 16924481
    [Abstract] [Full Text] [Related]

  • 20. Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
    Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L, Hvidøre Study Group.
    Eur J Endocrinol; 2007 Jun 24; 156(6):663-71. PubMed ID: 17535866
    [Abstract] [Full Text] [Related]


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