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319 related items for PubMed ID: 12373454

  • 1. Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells.
    Carvalho M, Hawksworth G, Milhazes N, Borges F, Monks TJ, Fernandes E, Carvalho F, Bastos ML.
    Arch Toxicol; 2002 Oct; 76(10):581-8. PubMed ID: 12373454
    [Abstract] [Full Text] [Related]

  • 2. Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates.
    Carvalho M, Milhazes N, Remião F, Borges F, Fernandes E, Amado F, Monks TJ, Carvalho F, Bastos ML.
    Arch Toxicol; 2004 Jan; 78(1):16-24. PubMed ID: 14586543
    [Abstract] [Full Text] [Related]

  • 3. Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia.
    Capela JP, Meisel A, Abreu AR, Branco PS, Ferreira LM, Lobo AM, Remião F, Bastos ML, Carvalho F.
    J Pharmacol Exp Ther; 2006 Jan; 316(1):53-61. PubMed ID: 16183702
    [Abstract] [Full Text] [Related]

  • 4. Neurotoxicity mechanisms of thioether ecstasy metabolites.
    Capela JP, Macedo C, Branco PS, Ferreira LM, Lobo AM, Fernandes E, Remião F, Bastos ML, Dirnagl U, Meisel A, Carvalho F.
    Neuroscience; 2007 Jun 08; 146(4):1743-57. PubMed ID: 17467183
    [Abstract] [Full Text] [Related]

  • 5. The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine.
    Carvalho M, Remião F, Milhazes N, Borges F, Fernandes E, Carvalho F, Bastos ML.
    Toxicology; 2004 Aug 05; 200(2-3):193-203. PubMed ID: 15212815
    [Abstract] [Full Text] [Related]

  • 6. Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.
    Carvalho M, Remião F, Milhazes N, Borges F, Fernandes E, Monteiro Mdo C, Gonçalves MJ, Seabra V, Amado F, Carvalho F, Bastos ML.
    Chem Res Toxicol; 2004 May 05; 17(5):623-32. PubMed ID: 15144219
    [Abstract] [Full Text] [Related]

  • 7. Effects of intracerebroventricular administration of 5-(glutathion-S-yl)-alpha-methyldopamine on brain dopamine, serotonin, and norepinephrine concentrations in male Sprague-Dawley rats.
    Miller RT, Lau SS, Monks TJ.
    Chem Res Toxicol; 1996 Mar 05; 9(2):457-65. PubMed ID: 8839050
    [Abstract] [Full Text] [Related]

  • 8. Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.
    Jones DC, Lau SS, Monks TJ.
    J Pharmacol Exp Ther; 2004 Oct 05; 311(1):298-306. PubMed ID: 15169827
    [Abstract] [Full Text] [Related]

  • 9. Bacterial plate assays and electrochemical methods: an efficient tandem for evaluating the ability of catechol-thioether metabolites of MDMA ("ecstasy") to induce toxic effects through redox-cycling.
    Felim A, Urios A, Neudörffer A, Herrera G, Blanco M, Largeron M.
    Chem Res Toxicol; 2007 Apr 05; 20(4):685-93. PubMed ID: 17355154
    [Abstract] [Full Text] [Related]

  • 10. Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase.
    Bai F, Jones DC, Lau SS, Monks TJ.
    Chem Res Toxicol; 2001 Jul 05; 14(7):863-70. PubMed ID: 11453733
    [Abstract] [Full Text] [Related]

  • 11. Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity.
    Bai F, Lau SS, Monks TJ.
    Chem Res Toxicol; 1999 Dec 05; 12(12):1150-7. PubMed ID: 10604863
    [Abstract] [Full Text] [Related]

  • 12. Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.
    Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, Monks TJ.
    J Pharmacol Exp Ther; 2005 Apr 05; 313(1):422-31. PubMed ID: 15634943
    [Abstract] [Full Text] [Related]

  • 13. Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.
    Ferreira PS, Nogueira TB, Costa VM, Branco PS, Ferreira LM, Fernandes E, Bastos ML, Meisel A, Carvalho F, Capela JP.
    Toxicol Lett; 2013 Feb 04; 216(2-3):159-70. PubMed ID: 23194825
    [Abstract] [Full Text] [Related]

  • 14. Glutathione conjugates of tert-butyl-hydroquinone, a metabolite of the urinary tract tumor promoter 3-tert-butyl-hydroxyanisole, are toxic to kidney and bladder.
    Peters MM, Rivera MI, Jones TW, Monks TJ, Lau SS.
    Cancer Res; 1996 Mar 01; 56(5):1006-11. PubMed ID: 8640754
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy).
    Easton N, Fry J, O'Shea E, Watkins A, Kingston S, Marsden CA.
    Brain Res; 2003 Oct 17; 987(2):144-54. PubMed ID: 14499958
    [Abstract] [Full Text] [Related]

  • 16. The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity.
    Monks TJ, Jones DC, Bai F, Lau SS.
    Ther Drug Monit; 2004 Apr 17; 26(2):132-6. PubMed ID: 15228153
    [Abstract] [Full Text] [Related]

  • 17. Hyperthermia Severely Affects the Vascular Effects of MDMA and Metabolites in the Human Internal Mammary Artery In Vitro.
    Fonseca DA, Guerra AF, Carvalho F, Fernandes E, Ferreira LM, Branco PS, Antunes PE, Antunes MJ, Cotrim MD.
    Cardiovasc Toxicol; 2017 Oct 17; 17(4):405-416. PubMed ID: 28084566
    [Abstract] [Full Text] [Related]

  • 18. Modulation of quinol/quinone-thioether toxicity by intramolecular detoxication.
    Monks TJ.
    Drug Metab Rev; 1995 Oct 17; 27(1-2):93-106. PubMed ID: 7641587
    [Abstract] [Full Text] [Related]

  • 19. "Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
    Barbosa DJ, Capela JP, Silva R, Ferreira LM, Branco PS, Fernandes E, Bastos ML, Carvalho F.
    Arch Toxicol; 2014 Feb 17; 88(2):515-31. PubMed ID: 24177245
    [Abstract] [Full Text] [Related]

  • 20. Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.
    Antolino-Lobo I, Meulenbelt J, Molendijk J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB.
    Toxicology; 2011 Nov 18; 289(2-3):175-84. PubMed ID: 21871945
    [Abstract] [Full Text] [Related]

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