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305 related items for PubMed ID: 12391316

  • 1. Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.
    Du F, Navarro-Garcia F, Xia Z, Tasaki T, Varshavsky A.
    Proc Natl Acad Sci U S A; 2002 Oct 29; 99(22):14110-5. PubMed ID: 12391316
    [Abstract] [Full Text] [Related]

  • 2. Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.
    Turner GC, Du F, Varshavsky A.
    Nature; 2000 Jun 01; 405(6786):579-83. PubMed ID: 10850718
    [Abstract] [Full Text] [Related]

  • 3. Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.
    Xia Z, Webster A, Du F, Piatkov K, Ghislain M, Varshavsky A.
    J Biol Chem; 2008 Aug 29; 283(35):24011-28. PubMed ID: 18566452
    [Abstract] [Full Text] [Related]

  • 4. Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.
    Xia Z, Turner GC, Hwang CS, Byrd C, Varshavsky A.
    J Biol Chem; 2008 Oct 24; 283(43):28958-68. PubMed ID: 18708352
    [Abstract] [Full Text] [Related]

  • 5. Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway.
    Hwang CS, Varshavsky A.
    Proc Natl Acad Sci U S A; 2008 Dec 09; 105(49):19188-93. PubMed ID: 19033468
    [Abstract] [Full Text] [Related]

  • 6. The N-end rule pathway is a sensor of heme.
    Hu RG, Wang H, Xia Z, Varshavsky A.
    Proc Natl Acad Sci U S A; 2008 Jan 08; 105(1):76-81. PubMed ID: 18162538
    [Abstract] [Full Text] [Related]

  • 7. The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
    Hwang CS, Shemorry A, Auerbach D, Varshavsky A.
    Nat Cell Biol; 2010 Dec 08; 12(12):1177-85. PubMed ID: 21076411
    [Abstract] [Full Text] [Related]

  • 8. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
    Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT.
    Mol Cell Biol; 2005 Aug 08; 25(16):7120-36. PubMed ID: 16055722
    [Abstract] [Full Text] [Related]

  • 9. The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor.
    Byrd C, Turner GC, Varshavsky A.
    EMBO J; 1998 Jan 02; 17(1):269-77. PubMed ID: 9427760
    [Abstract] [Full Text] [Related]

  • 10. The substrate recognition domains of the N-end rule pathway.
    Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT.
    J Biol Chem; 2009 Jan 16; 284(3):1884-95. PubMed ID: 19008229
    [Abstract] [Full Text] [Related]

  • 11. Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases.
    Hickey CM, Breckel C, Zhang M, Theune WC, Hochstrasser M.
    Genetics; 2021 Mar 03; 217(1):1-19. PubMed ID: 33683364
    [Abstract] [Full Text] [Related]

  • 12. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
    Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK.
    Nat Struct Mol Biol; 2010 Oct 03; 17(10):1175-81. PubMed ID: 20835240
    [Abstract] [Full Text] [Related]

  • 13. The mouse and human genes encoding the recognition component of the N-end rule pathway.
    Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA, Varshavsky A.
    Proc Natl Acad Sci U S A; 1998 Jul 07; 95(14):7898-903. PubMed ID: 9653112
    [Abstract] [Full Text] [Related]

  • 14. Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling.
    Oh JH, Hyun JY, Chen SJ, Varshavsky A.
    Proc Natl Acad Sci U S A; 2020 May 19; 117(20):10778-10788. PubMed ID: 32366662
    [Abstract] [Full Text] [Related]

  • 15. Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae.
    Cai H, Hauser M, Naider F, Becker JM.
    Eukaryot Cell; 2007 Oct 19; 6(10):1805-13. PubMed ID: 17693598
    [Abstract] [Full Text] [Related]

  • 16. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
    Kwon YT, Xia Z, Davydov IV, Lecker SH, Varshavsky A.
    Mol Cell Biol; 2001 Dec 19; 21(23):8007-21. PubMed ID: 11689692
    [Abstract] [Full Text] [Related]

  • 17. Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.
    Eisele F, Wolf DH.
    FEBS Lett; 2008 Dec 24; 582(30):4143-6. PubMed ID: 19041308
    [Abstract] [Full Text] [Related]

  • 18. Functional implications and ubiquitin-dependent degradation of the peptide transporter Ptr2 in Saccharomyces cerevisiae.
    Kawai K, Moriya A, Uemura S, Abe F.
    Eukaryot Cell; 2014 Nov 24; 13(11):1380-92. PubMed ID: 25172766
    [Abstract] [Full Text] [Related]

  • 19. Structural insights into Ubr1-mediated N-degron polyubiquitination.
    Pan M, Zheng Q, Wang T, Liang L, Mao J, Zuo C, Ding R, Ai H, Xie Y, Si D, Yu Y, Liu L, Zhao M.
    Nature; 2021 Dec 24; 600(7888):334-338. PubMed ID: 34789879
    [Abstract] [Full Text] [Related]

  • 20. Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.
    Oh JH, Hyun JY, Varshavsky A.
    Proc Natl Acad Sci U S A; 2017 May 30; 114(22):E4370-E4379. PubMed ID: 28515311
    [Abstract] [Full Text] [Related]

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