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Journal Abstract Search

209 related items for PubMed ID: 12414642

  • 1. Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.
    Bardelmeijer HA, Ouwehand M, Buckle T, Huisman MT, Schellens JH, Beijnen JH, van Tellingen O.
    Cancer Res; 2002 Nov 01; 62(21):6158-64. PubMed ID: 12414642
    [Abstract] [Full Text] [Related]

  • 2. P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
    Hendrikx JJ, Lagas JS, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.
    Int J Cancer; 2013 May 15; 132(10):2439-47. PubMed ID: 23090875
    [Abstract] [Full Text] [Related]

  • 3. Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.
    van Waterschoot RA, Lagas JS, Wagenaar E, Rosing H, Beijnen JH, Schinkel AH.
    Int J Cancer; 2010 Dec 15; 127(12):2959-64. PubMed ID: 21351274
    [Abstract] [Full Text] [Related]

  • 4. Oral delivery of taxanes.
    Malingré MM, Beijnen JH, Schellens JH.
    Invest New Drugs; 2001 May 15; 19(2):155-62. PubMed ID: 11392449
    [Abstract] [Full Text] [Related]

  • 5. Role of intestinal P-glycoprotein in the plasma and fecal disposition of docetaxel in humans.
    van Zuylen L, Verweij J, Nooter K, Brouwer E, Stoter G, Sparreboom A.
    Clin Cancer Res; 2000 Jul 15; 6(7):2598-603. PubMed ID: 10914699
    [Abstract] [Full Text] [Related]

  • 6. The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice.
    Press RR, Buckle T, Beijnen JH, van Tellingen O.
    Cancer Chemother Pharmacol; 2006 Jun 15; 57(6):819-25. PubMed ID: 16163538
    [Abstract] [Full Text] [Related]

  • 7. Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.
    Cao J, Chen X, Liang J, Yu XQ, Xu AL, Chan E, Wei D, Huang M, Wen JY, Yu XY, Li XT, Sheu FS, Zhou SF.
    Drug Metab Dispos; 2007 Apr 15; 35(4):539-53. PubMed ID: 17220245
    [Abstract] [Full Text] [Related]

  • 8. Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir.
    Huisman MT, Smit JW, Wiltshire HR, Beijnen JH, Schinkel AH.
    J Pharmacol Exp Ther; 2003 Feb 15; 304(2):596-602. PubMed ID: 12538811
    [Abstract] [Full Text] [Related]

  • 9. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.
    Durmus S, Xu N, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.
    Pharmacol Res; 2013 Oct 15; 76():9-16. PubMed ID: 23827160
    [Abstract] [Full Text] [Related]

  • 10. Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.
    van Waterschoot RA, Lagas JS, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Song JY, Rooswinkel RW, van Tellingen O, Rosing H, Beijnen JH, Schinkel AH.
    Cancer Res; 2009 Dec 01; 69(23):8996-9002. PubMed ID: 19920203
    [Abstract] [Full Text] [Related]

  • 11. Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.
    Oostendorp RL, Huitema A, Rosing H, Jansen RS, Ter Heine R, Keessen M, Beijnen JH, Schellens JH.
    Clin Cancer Res; 2009 Jun 15; 15(12):4228-33. PubMed ID: 19509162
    [Abstract] [Full Text] [Related]

  • 12. Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
    Tang SC, Nguyen LN, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.
    Int J Cancer; 2014 Mar 15; 134(6):1484-94. PubMed ID: 24037730
    [Abstract] [Full Text] [Related]

  • 13. Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone.
    Jin M, Shimada T, Yokogawa K, Nomura M, Kato Y, Tsuji A, Miyamoto K.
    Int J Pharm; 2006 Feb 17; 309(1-2):81-6. PubMed ID: 16384676
    [Abstract] [Full Text] [Related]

  • 14. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse.
    Booth-Genthe CL, Louie SW, Carlini EJ, Li B, Leake BF, Eisenhandler R, Hochman JH, Mei Q, Kim RB, Rushmore TH, Yamazaki M.
    J Pharmacol Toxicol Methods; 2006 Feb 17; 54(1):78-89. PubMed ID: 16545584
    [Abstract] [Full Text] [Related]

  • 15. Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice.
    Jin M, Shimada T, Yokogawa K, Nomura M, Ishizaki J, Piao Y, Kato Y, Tsuji A, Miyamoto K.
    Biochem Pharmacol; 2006 Oct 16; 72(8):1042-50. PubMed ID: 16939683
    [Abstract] [Full Text] [Related]

  • 16. Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.
    Takeuchi T, Yoshitomi S, Higuchi T, Ikemoto K, Niwa S, Ebihara T, Katoh M, Yokoi T, Asahi S.
    Pharm Res; 2006 Jul 16; 23(7):1460-72. PubMed ID: 16779700
    [Abstract] [Full Text] [Related]

  • 17. Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.
    Hendrikx JJ, Lagas JS, Wagenaar E, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.
    Br J Cancer; 2014 May 27; 110(11):2669-76. PubMed ID: 24781280
    [Abstract] [Full Text] [Related]

  • 18. Interaction of docetaxel ("Taxotere") with human P-glycoprotein.
    Shirakawa K, Takara K, Tanigawara Y, Aoyama N, Kasuga M, Komada F, Sakaeda T, Okumura K.
    Jpn J Cancer Res; 1999 Dec 27; 90(12):1380-6. PubMed ID: 10665657
    [Abstract] [Full Text] [Related]

  • 19. Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.
    Bardelmeijer HA, Beijnen JH, Brouwer KR, Rosing H, Nooijen WJ, Schellens JH, van Tellingen O.
    Clin Cancer Res; 2000 Nov 27; 6(11):4416-21. PubMed ID: 11106262
    [Abstract] [Full Text] [Related]

  • 20. Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer.
    Koolen SL, Oostendorp RL, Beijnen JH, Schellens JH, Huitema AD.
    Br J Clin Pharmacol; 2010 May 27; 69(5):465-74. PubMed ID: 20573082
    [Abstract] [Full Text] [Related]

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