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912 related items for PubMed ID: 12421919

  • 1. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
    Freeburn RW, Wright KL, Burgess SJ, Astoul E, Cantrell DA, Ward SG.
    J Immunol; 2002 Nov 15; 169(10):5441-50. PubMed ID: 12421919
    [Abstract] [Full Text] [Related]

  • 2. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
    Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.
    Mol Cell Biol; 2000 Sep 15; 20(18):6945-57. PubMed ID: 10958690
    [Abstract] [Full Text] [Related]

  • 3. Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.
    Wain CM, Westwick J, Ward SG.
    Cell Signal; 2005 Oct 15; 17(10):1194-202. PubMed ID: 16038794
    [Abstract] [Full Text] [Related]

  • 4. 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
    Taylor V, Wong M, Brandts C, Reilly L, Dean NM, Cowsert LM, Moodie S, Stokoe D.
    Mol Cell Biol; 2000 Sep 15; 20(18):6860-71. PubMed ID: 10958682
    [Abstract] [Full Text] [Related]

  • 5. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.
    Mol Endocrinol; 2001 Aug 15; 15(8):1411-22. PubMed ID: 11463863
    [Abstract] [Full Text] [Related]

  • 6. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
    Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.
    J Biol Chem; 2005 Jun 10; 280(23):22523-9. PubMed ID: 15824124
    [Abstract] [Full Text] [Related]

  • 7. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
    Horn S, Endl E, Fehse B, Weck MM, Mayr GW, Jücker M.
    Leukemia; 2004 Nov 10; 18(11):1839-49. PubMed ID: 15457186
    [Abstract] [Full Text] [Related]

  • 8. Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice.
    Scheid MP, Huber M, Damen JE, Hughes M, Kang V, Neilsen P, Prestwich GD, Krystal G, Duronio V.
    J Biol Chem; 2002 Mar 15; 277(11):9027-35. PubMed ID: 11781306
    [Abstract] [Full Text] [Related]

  • 9. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
    Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W.
    Oncogene; 2002 Aug 08; 21(34):5289-300. PubMed ID: 12149650
    [Abstract] [Full Text] [Related]

  • 10. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.
    Wang X, Gjörloff-Wingren A, Saxena M, Pathan N, Reed JC, Mustelin T.
    J Immunol; 2000 Feb 15; 164(4):1934-9. PubMed ID: 10657643
    [Abstract] [Full Text] [Related]

  • 11. Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells.
    Brauweiler A, Tamir I, Marschner S, Helgason CD, Cambier JC.
    J Immunol; 2001 Jul 01; 167(1):204-11. PubMed ID: 11418650
    [Abstract] [Full Text] [Related]

  • 12. Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes.
    Kamen LA, Levinsohn J, Swanson JA.
    Mol Biol Cell; 2007 Jul 01; 18(7):2463-72. PubMed ID: 17442886
    [Abstract] [Full Text] [Related]

  • 13. PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.
    Seminario MC, Precht P, Bunnell SC, Warren SE, Morris CM, Taub D, Wange RL.
    Eur J Immunol; 2004 Nov 01; 34(11):3165-75. PubMed ID: 15468057
    [Abstract] [Full Text] [Related]

  • 14. Two distinct waves of membrane-proximal B cell antigen receptor signaling differentially regulated by Src homology 2-containing inositol polyphosphate 5-phosphatase.
    Krahn AK, Ma K, Hou S, Duronio V, Marshall AJ.
    J Immunol; 2004 Jan 01; 172(1):331-9. PubMed ID: 14688341
    [Abstract] [Full Text] [Related]

  • 15. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.
    Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB.
    J Biol Chem; 2003 Oct 03; 278(40):38628-36. PubMed ID: 12882960
    [Abstract] [Full Text] [Related]

  • 16. Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.
    Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.
    Cell Signal; 2007 Dec 03; 19(12):2444-57. PubMed ID: 17826953
    [Abstract] [Full Text] [Related]

  • 17. CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP.
    Edmunds C, Parry RV, Burgess SJ, Reaves B, Ward SG.
    Eur J Immunol; 1999 Nov 03; 29(11):3507-15. PubMed ID: 10556805
    [Abstract] [Full Text] [Related]

  • 18. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.
    Sharrard RM, Maitland NJ.
    Cell Signal; 2007 Jan 03; 19(1):129-38. PubMed ID: 16842970
    [Abstract] [Full Text] [Related]

  • 19. SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles.
    Déléris P, Bacqueville D, Gayral S, Carrez L, Salles JP, Perret B, Breton-Douillon M.
    J Biol Chem; 2003 Oct 03; 278(40):38884-91. PubMed ID: 12847108
    [Abstract] [Full Text] [Related]

  • 20. Thapsigargin-induced degranulation of mast cells is dependent on transient activation of phosphatidylinositol-3 kinase.
    Huber M, Hughes MR, Krystal G.
    J Immunol; 2000 Jul 01; 165(1):124-33. PubMed ID: 10861044
    [Abstract] [Full Text] [Related]

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