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1166 related items for PubMed ID: 12423249

  • 1. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D, Kienlen-Campard P, Octave JN.
    J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
    [Abstract] [Full Text] [Related]

  • 2. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H, Capell A, Leimer U, Haass C.
    Eur Arch Psychiatry Clin Neurosci; 1999 Oct; 249(6):266-70. PubMed ID: 10653281
    [Abstract] [Full Text] [Related]

  • 3. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W.
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
    [Abstract] [Full Text] [Related]

  • 4. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.
    Octave JN, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L.
    J Biol Chem; 2000 Jan 21; 275(3):1525-8. PubMed ID: 10636839
    [Abstract] [Full Text] [Related]

  • 5. Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
    Pitsi D, Octave JN.
    J Biol Chem; 2004 Jun 11; 279(24):25333-8. PubMed ID: 15087467
    [Abstract] [Full Text] [Related]

  • 6. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
    Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.
    J Cell Biol; 2001 Aug 20; 154(4):731-40. PubMed ID: 11502763
    [Abstract] [Full Text] [Related]

  • 7. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 8. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
    [Abstract] [Full Text] [Related]

  • 9. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R.
    J Mol Neurosci; 2004 Aug 05; 23(1-2):105-14. PubMed ID: 15126696
    [Abstract] [Full Text] [Related]

  • 10. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ.
    Neurobiol Dis; 2000 Dec 05; 7(6 Pt B):673-81. PubMed ID: 11114265
    [Abstract] [Full Text] [Related]

  • 11. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T, Ma G, Cai H, Price DL, Wong PC.
    J Neurosci; 2003 Apr 15; 23(8):3272-7. PubMed ID: 12716934
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.
    Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T.
    J Neurosci; 2002 Mar 01; 22(5):1679-89. PubMed ID: 11880497
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  • 14. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
    Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.
    J Neurosci; 2002 May 01; 22(9):3445-53. PubMed ID: 11978821
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  • 16. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
    Vassar R.
    J Mol Neurosci; 2001 Oct 01; 17(2):157-70. PubMed ID: 11816789
    [Abstract] [Full Text] [Related]

  • 17. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.
    Jung CG, Uhm KO, Horike H, Kim MJ, Misumi S, Ishida A, Ueda Y, Choi EK, Kim YS, Michikawa M, Hida H.
    J Alzheimers Dis; 2015 Oct 01; 43(4):1215-28. PubMed ID: 25147119
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  • 19. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 01; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 20. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
    Cai Z, Wang C, He W, Chen Y.
    Curr Alzheimer Res; 2018 Jun 01; 15(11):1045-1052. PubMed ID: 29962345
    [Abstract] [Full Text] [Related]

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