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198 related items for PubMed ID: 12429924

  • 1. Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.
    Dai Y, Dent P, Grant S.
    Cell Cycle; 2002; 1(2):143-52. PubMed ID: 12429924
    [Abstract] [Full Text] [Related]

  • 2. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
    Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala HM, Dent P, Grant S.
    Cancer Res; 2001 Mar 15; 61(6):2583-91. PubMed ID: 11289135
    [Abstract] [Full Text] [Related]

  • 3. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
    Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S.
    Cancer Res; 2003 Apr 15; 63(8):1822-33. PubMed ID: 12702569
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes.
    Hauck L, Hansmann G, Dietz R, von Harsdorf R.
    Circ Res; 2002 Nov 01; 91(9):782-9. PubMed ID: 12411392
    [Abstract] [Full Text] [Related]

  • 5. Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells.
    Bhatia N, Agarwal C, Agarwal R.
    Nutr Cancer; 2001 Nov 01; 39(2):292-9. PubMed ID: 11759294
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
    Dai Y, Yu C, Singh V, Tang L, Wang Z, McInistry R, Dent P, Grant S.
    Cancer Res; 2001 Jul 01; 61(13):5106-15. PubMed ID: 11431348
    [Abstract] [Full Text] [Related]

  • 7. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.
    Rosato RR, Almenara JA, Grant S.
    Cancer Res; 2003 Jul 01; 63(13):3637-45. PubMed ID: 12839953
    [Abstract] [Full Text] [Related]

  • 8. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein.
    Reshetnikova G, Barkan R, Popov B, Nikolsky N, Chang LS.
    Exp Cell Res; 2000 Aug 25; 259(1):35-53. PubMed ID: 10942577
    [Abstract] [Full Text] [Related]

  • 9. The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.
    Maggio SC, Rosato RR, Kramer LB, Dai Y, Rahmani M, Paik DS, Czarnik AC, Payne SG, Spiegel S, Grant S.
    Cancer Res; 2004 Apr 01; 64(7):2590-600. PubMed ID: 15059916
    [Abstract] [Full Text] [Related]

  • 10. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
    Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S.
    Cancer Res; 2002 Jan 01; 62(1):188-99. PubMed ID: 11782377
    [Abstract] [Full Text] [Related]

  • 11. Adhesion-regulated G1 cell cycle arrest in epithelial cells requires the downregulation of c-Myc.
    Benaud CM, Dickson RB.
    Oncogene; 2001 Jul 27; 20(33):4554-67. PubMed ID: 11494151
    [Abstract] [Full Text] [Related]

  • 12. Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.
    Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J.
    J Biol Chem; 2005 Apr 01; 280(13):12339-43. PubMed ID: 15713665
    [Abstract] [Full Text] [Related]

  • 13. Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip).
    Chen WJ, Chang CY, Lin JK.
    Biochem Pharmacol; 2003 Jun 01; 65(11):1777-85. PubMed ID: 12781329
    [Abstract] [Full Text] [Related]

  • 14. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
    Hahn M, Li W, Yu C, Rahmani M, Dent P, Grant S.
    Mol Cancer Ther; 2005 Mar 01; 4(3):457-70. PubMed ID: 15767555
    [Abstract] [Full Text] [Related]

  • 15. Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.
    Rosato RR, Almenara JA, Dai Y, Grant S.
    Mol Cancer Ther; 2003 Dec 01; 2(12):1273-84. PubMed ID: 14707268
    [Abstract] [Full Text] [Related]

  • 16. Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.
    Yu C, Wang S, Dent P, Grant S.
    Mol Pharmacol; 2001 Jul 01; 60(1):143-54. PubMed ID: 11408609
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition.
    Rahmani M, Yu C, Reese E, Ahmed W, Hirsch K, Dent P, Grant S.
    Oncogene; 2003 Sep 18; 22(40):6231-42. PubMed ID: 13679862
    [Abstract] [Full Text] [Related]

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  • 20. Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.
    Wang Z, Van Tuyle G, Conrad D, Fisher PB, Dent P, Grant S.
    Cancer Res; 1999 Mar 15; 59(6):1259-67. PubMed ID: 10096557
    [Abstract] [Full Text] [Related]

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