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236 related items for PubMed ID: 12460542

  • 1. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
    Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP.
    Neurobiol Dis; 2002 Oct; 11(1):2-19. PubMed ID: 12460542
    [Abstract] [Full Text] [Related]

  • 2. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.
    Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP.
    J Neurosci; 1998 Jun 15; 18(12):4439-50. PubMed ID: 9614221
    [Abstract] [Full Text] [Related]

  • 3. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 4. Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.
    Milhavet O, Martindale JL, Camandola S, Chan SL, Gary DS, Cheng A, Holbrook NJ, Mattson MP.
    J Neurochem; 2002 Nov 15; 83(3):673-81. PubMed ID: 12390529
    [Abstract] [Full Text] [Related]

  • 5. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons.
    Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP.
    J Biol Chem; 2000 Jun 16; 275(24):18195-200. PubMed ID: 10764737
    [Abstract] [Full Text] [Related]

  • 6. Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
    Siman R, Flood DG, Thinakaran G, Neumar RW.
    J Biol Chem; 2001 Nov 30; 276(48):44736-43. PubMed ID: 11574534
    [Abstract] [Full Text] [Related]

  • 7. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
    Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
    J Neurochem; 1999 Mar 30; 72(3):1019-29. PubMed ID: 10037473
    [Abstract] [Full Text] [Related]

  • 8. Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
    Xie J, Chang X, Zhang X, Guo Q.
    Brain Res; 2001 Oct 05; 915(1):1-10. PubMed ID: 11578614
    [Abstract] [Full Text] [Related]

  • 9. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
    Mattson MP, Zhu H, Yu J, Kindy MS.
    J Neurosci; 2000 Feb 15; 20(4):1358-64. PubMed ID: 10662826
    [Abstract] [Full Text] [Related]

  • 10. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
    Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP.
    J Neurosci; 1997 Jun 01; 17(11):4212-22. PubMed ID: 9151738
    [Abstract] [Full Text] [Related]

  • 11. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC, Ghadge GD, Miller RJ, Roos RP.
    J Neurochem; 1999 Jul 01; 73(1):31-40. PubMed ID: 10386952
    [Abstract] [Full Text] [Related]

  • 12. Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.
    Mattson MP, Gary DS, Chan SL, Duan W.
    Biochem Soc Symp; 2001 Jul 01; (67):151-62. PubMed ID: 11447832
    [Abstract] [Full Text] [Related]

  • 13. Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.
    Popescu BO, Cedazo-Minguez A, Popescu LM, Winblad B, Cowburn RF, Ankarcrona M.
    J Neurosci Res; 2001 Oct 01; 66(1):122-34. PubMed ID: 11599009
    [Abstract] [Full Text] [Related]

  • 14. Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function.
    Han J, Park H, Maharana C, Gwon AR, Park J, Baek SH, Bae HG, Cho Y, Kim HK, Sul JH, Lee J, Kim E, Kim J, Cho Y, Park S, Palomera LF, Arumugam TV, Mattson MP, Jo DG.
    Theranostics; 2021 Oct 01; 11(18):8855-8873. PubMed ID: 34522215
    [Abstract] [Full Text] [Related]

  • 15. Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Oct 01; 16(3):551-64. PubMed ID: 19276550
    [Abstract] [Full Text] [Related]

  • 16. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
    Begley JG, Duan W, Chan S, Duff K, Mattson MP.
    J Neurochem; 1999 Mar 01; 72(3):1030-9. PubMed ID: 10037474
    [Abstract] [Full Text] [Related]

  • 17. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
    Guo Q, Sebastian L, Sopher BL, Miller MW, Glazner GW, Ware CB, Martin GM, Mattson MP.
    Proc Natl Acad Sci U S A; 1999 Mar 30; 96(7):4125-30. PubMed ID: 10097174
    [Abstract] [Full Text] [Related]

  • 18. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 30; 8(2):331-42. PubMed ID: 11300728
    [Abstract] [Full Text] [Related]

  • 19. Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease.
    Chan SL, Pedersen WA, Zhu H, Mattson MP.
    Neuromolecular Med; 2002 Apr 30; 1(1):55-67. PubMed ID: 12025816
    [Abstract] [Full Text] [Related]

  • 20. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
    Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE.
    J Neurochem; 1999 Dec 30; 73(6):2278-85. PubMed ID: 10582585
    [Abstract] [Full Text] [Related]

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