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310 related items for PubMed ID: 12464660

  • 1. Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy.
    Lomas DA, Mahadeva R.
    J Clin Invest; 2002 Dec; 110(11):1585-90. PubMed ID: 12464660
    [No Abstract] [Full Text] [Related]

  • 2. Probing the local conformational change of alpha1-antitrypsin.
    Baek JH, Im H, Kang UB, Seong KM, Lee C, Kim J, Yu MH.
    Protein Sci; 2007 Sep; 16(9):1842-50. PubMed ID: 17660256
    [Abstract] [Full Text] [Related]

  • 3. Alpha 1-antitrypsin polymerisation can occur by both loop A and C sheet mechanisms.
    Bottomley SP, Hopkins PC, Whisstock JC.
    Biochem Biophys Res Commun; 1998 Oct 09; 251(1):1-5. PubMed ID: 9790897
    [Abstract] [Full Text] [Related]

  • 4. Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.
    Crowther DC, Belorgey D, Miranda E, Kinghorn KJ, Sharp LK, Lomas DA.
    Eur J Hum Genet; 2004 Mar 09; 12(3):167-72. PubMed ID: 14694355
    [Abstract] [Full Text] [Related]

  • 5. Alpha1-antitrypsin deficiency--a model for conformational diseases.
    Carrell RW, Lomas DA.
    N Engl J Med; 2002 Jan 03; 346(1):45-53. PubMed ID: 11778003
    [No Abstract] [Full Text] [Related]

  • 6. Cleaved antitrypsin polymers at atomic resolution.
    Dunstone MA, Dai W, Whisstock JC, Rossjohn J, Pike RN, Feil SC, Le Bonniec BF, Parker MW, Bottomley SP.
    Protein Sci; 2000 Feb 03; 9(2):417-20. PubMed ID: 10716194
    [Abstract] [Full Text] [Related]

  • 7. Role of Lys335 in the metastability and function of inhibitory serpins.
    Im H, Yu MH.
    Protein Sci; 2000 May 03; 9(5):934-41. PubMed ID: 10850803
    [Abstract] [Full Text] [Related]

  • 8. Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.
    Knaupp AS, Levina V, Robertson AL, Pearce MC, Bottomley SP.
    J Mol Biol; 2010 Feb 19; 396(2):375-83. PubMed ID: 19944704
    [Abstract] [Full Text] [Related]

  • 9. The molecular aetiology of the serpinopathies.
    Davies MJ, Lomas DA.
    Int J Biochem Cell Biol; 2008 Feb 19; 40(6-7):1273-86. PubMed ID: 18289918
    [Abstract] [Full Text] [Related]

  • 10. Serpin polymerization and its role in disease--the molecular basis of alpha1-antitrypsin deficiency.
    Knaupp AS, Bottomley SP.
    IUBMB Life; 2009 Jan 19; 61(1):1-5. PubMed ID: 18785256
    [Abstract] [Full Text] [Related]

  • 11. Osmolytes as modulators of conformational changes in serpins.
    Chow MK, Devlin GL, Bottomley SP.
    Biol Chem; 2001 Nov 19; 382(11):1593-9. PubMed ID: 11767949
    [Abstract] [Full Text] [Related]

  • 12. Structure of a serpin-protease complex shows inhibition by deformation.
    Huntington JA, Read RJ, Carrell RW.
    Nature; 2000 Oct 19; 407(6806):923-6. PubMed ID: 11057674
    [Abstract] [Full Text] [Related]

  • 13. Picture story. The 'serpin'ator.
    Konforti B.
    Nat Struct Biol; 2000 Nov 19; 7(11):1005. PubMed ID: 11062552
    [No Abstract] [Full Text] [Related]

  • 14. Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.
    Lomas DA, Belorgey D, Mallya M, Onda M, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Crowther DC, Miranda E.
    Front Biosci; 2004 Sep 01; 9():2873-91. PubMed ID: 15353322
    [Abstract] [Full Text] [Related]

  • 15. Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia.
    Lomas DA, Lourbakos A, Cumming SA, Belorgey D.
    Biochem Soc Trans; 2002 Apr 01; 30(2):89-92. PubMed ID: 12023831
    [Abstract] [Full Text] [Related]

  • 16. Molecular pathogenesis of alpha-1-antitrypsin deficiency.
    Duvoix A, Roussel BD, Lomas DA.
    Rev Mal Respir; 2014 Dec 01; 31(10):992-1002. PubMed ID: 25442121
    [Abstract] [Full Text] [Related]

  • 17. Molecular pathogenesis of liver disease in alpha1-antitrypsin deficiency.
    Teckman JH, Qu D, Perlmutter DH.
    Hepatology; 1996 Dec 01; 24(6):1504-16. PubMed ID: 8938188
    [No Abstract] [Full Text] [Related]

  • 18. Engineering thermostability in serine protease inhibitors.
    Im H, Ryu MJ, Yu MH.
    Protein Eng Des Sel; 2004 Apr 01; 17(4):325-31. PubMed ID: 15126675
    [Abstract] [Full Text] [Related]

  • 19. Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex.
    Peterson FC, Gettins PG.
    Biochemistry; 2001 May 29; 40(21):6284-92. PubMed ID: 11371190
    [Abstract] [Full Text] [Related]

  • 20. High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin.
    Jagger AM, Waudby CA, Irving JA, Christodoulou J, Lomas DA.
    Nat Commun; 2020 Dec 11; 11(1):6371. PubMed ID: 33311470
    [Abstract] [Full Text] [Related]

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