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857 related items for PubMed ID: 12481428

  • 1. X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO).
    Ng CP, Bonavida B.
    Mol Cancer Ther; 2002 Oct; 1(12):1051-8. PubMed ID: 12481428
    [Abstract] [Full Text] [Related]

  • 2. Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: role of XIAP in resistance.
    Ng CP, Zisman A, Bonavida B.
    Prostate; 2002 Dec 01; 53(4):286-99. PubMed ID: 12430140
    [Abstract] [Full Text] [Related]

  • 3. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.
    Zhang XD, Zhang XY, Gray CP, Nguyen T, Hersey P.
    Cancer Res; 2001 Oct 01; 61(19):7339-48. PubMed ID: 11585775
    [Abstract] [Full Text] [Related]

  • 4. Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.
    Guo F, Nimmanapalli R, Paranawithana S, Wittman S, Griffin D, Bali P, O'Bryan E, Fumero C, Wang HG, Bhalla K.
    Blood; 2002 May 01; 99(9):3419-26. PubMed ID: 11964312
    [Abstract] [Full Text] [Related]

  • 5. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
    Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES.
    J Biol Chem; 2000 Nov 17; 275(46):36152-7. PubMed ID: 10950947
    [Abstract] [Full Text] [Related]

  • 6. Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria.
    Zhang XD, Borrow JM, Zhang XY, Nguyen T, Hersey P.
    Oncogene; 2003 May 15; 22(19):2869-81. PubMed ID: 12771938
    [Abstract] [Full Text] [Related]

  • 7. X-linked inhibitor regulating TRAIL-induced apoptosis in chemoresistant human primary glioblastoma cells.
    Roa WH, Chen H, Fulton D, Gulavita S, Shaw A, Th'ng J, Farr-Jones M, Moore R, Petruk K.
    Clin Invest Med; 2003 Oct 15; 26(5):231-42. PubMed ID: 14596484
    [Abstract] [Full Text] [Related]

  • 8. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
    Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK.
    Cancer Res; 2003 Apr 01; 63(7):1712-21. PubMed ID: 12670926
    [Abstract] [Full Text] [Related]

  • 9. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
    MacFarlane M, Merrison W, Bratton SB, Cohen GM.
    J Biol Chem; 2002 Sep 27; 277(39):36611-6. PubMed ID: 12121969
    [Abstract] [Full Text] [Related]

  • 10. Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
    Rosato RR, Dai Y, Almenara JA, Maggio SC, Grant S.
    Leukemia; 2004 Nov 27; 18(11):1780-8. PubMed ID: 15385934
    [Abstract] [Full Text] [Related]

  • 11. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
    Deng Y, Lin Y, Wu X.
    Genes Dev; 2002 Jan 01; 16(1):33-45. PubMed ID: 11782443
    [Abstract] [Full Text] [Related]

  • 12. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.
    Bockbrader KM, Tan M, Sun Y.
    Oncogene; 2005 Nov 10; 24(49):7381-8. PubMed ID: 16044155
    [Abstract] [Full Text] [Related]

  • 13. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.
    Fulda S, Wick W, Weller M, Debatin KM.
    Nat Med; 2002 Aug 10; 8(8):808-15. PubMed ID: 12118245
    [Abstract] [Full Text] [Related]

  • 14. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells.
    Sinicrope FA, Penington RC, Tang XM.
    Clin Cancer Res; 2004 Dec 15; 10(24):8284-92. PubMed ID: 15623604
    [Abstract] [Full Text] [Related]

  • 15. Actinomycin D and gemcitabine synergistically sensitize androgen-independent prostate cancer cells to Apo2L/TRAIL-mediated apoptosis.
    Zisman A, Ng CP, Pantuck AJ, Bonavida B, Belldegrun AS.
    J Immunother; 2001 Dec 15; 24(6):459-71. PubMed ID: 11759069
    [Abstract] [Full Text] [Related]

  • 16. A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.
    Dai Y, Liu M, Tang W, Li Y, Lian J, Lawrence TS, Xu L.
    BMC Cancer; 2009 Nov 06; 9():392. PubMed ID: 19895686
    [Abstract] [Full Text] [Related]

  • 17. Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis.
    Jazirehi AR, Ng CP, Gan XH, Schiller G, Bonavida B.
    Clin Cancer Res; 2001 Dec 06; 7(12):3874-83. PubMed ID: 11751478
    [Abstract] [Full Text] [Related]

  • 18. Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.
    Izeradjene K, Douglas L, Tillman DM, Delaney AB, Houghton JA.
    Cancer Res; 2005 Aug 15; 65(16):7436-45. PubMed ID: 16103097
    [Abstract] [Full Text] [Related]

  • 19. Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells.
    Poulaki V, Mitsiades CS, Kotoula V, Tseleni-Balafouta S, Ashkenazi A, Koutras DA, Mitsiades N.
    Am J Pathol; 2002 Aug 15; 161(2):643-54. PubMed ID: 12163389
    [Abstract] [Full Text] [Related]

  • 20. Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.
    Fu J, Jin Y, Arend LJ.
    J Biol Chem; 2003 Dec 26; 278(52):52660-72. PubMed ID: 14523016
    [Abstract] [Full Text] [Related]


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