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207 related items for PubMed ID: 12504804

  • 1. Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity.
    Miguel JC, Abdel-Wahab YH, Green BD, Mathias PC, Flatt PR.
    Biochem Pharmacol; 2003 Jan 15; 65(2):283-92. PubMed ID: 12504804
    [Abstract] [Full Text] [Related]

  • 2. Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line.
    Miguel JC, Abdel-Wahab YH, Mathias PC, Flatt PR.
    Biochim Biophys Acta; 2002 Jan 15; 1569(1-3):45-50. PubMed ID: 11853956
    [Abstract] [Full Text] [Related]

  • 3. Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells.
    Salapatek AM, MacDonald PE, Gaisano HY, Wheeler MB.
    Mol Endocrinol; 1999 Aug 15; 13(8):1305-17. PubMed ID: 10446905
    [Abstract] [Full Text] [Related]

  • 4. Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
    Laychock SG.
    Mol Cell Endocrinol; 1995 Aug 30; 113(1):19-28. PubMed ID: 8674810
    [Abstract] [Full Text] [Related]

  • 5. Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin.
    Gault VA, O'Harte FP, Harriott P, Mooney MH, Green BD, Flatt PR.
    Diabetologia; 2003 Feb 30; 46(2):222-30. PubMed ID: 12627321
    [Abstract] [Full Text] [Related]

  • 6. Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq.
    Murthy KS, Makhlouf GM.
    J Biol Chem; 1997 Aug 22; 272(34):21317-24. PubMed ID: 9261144
    [Abstract] [Full Text] [Related]

  • 7. Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production.
    Dolz M, Bailbé D, Giroix MH, Calderari S, Gangnerau MN, Serradas P, Rickenbach K, Irminger JC, Portha B.
    Diabetes; 2005 Nov 22; 54(11):3229-37. PubMed ID: 16249449
    [Abstract] [Full Text] [Related]

  • 8. Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.
    Abello J, Ye F, Bosshard A, Bernard C, Cuber JC, Chayvialle JA.
    Endocrinology; 1994 May 22; 134(5):2011-7. PubMed ID: 8156901
    [Abstract] [Full Text] [Related]

  • 9. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.
    Delmeire D, Flamez D, Hinke SA, Cali JJ, Pipeleers D, Schuit F.
    Diabetologia; 2003 Oct 22; 46(10):1383-93. PubMed ID: 13680124
    [Abstract] [Full Text] [Related]

  • 10. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells.
    Anini Y, Brubaker PL.
    Endocrinology; 2003 Jul 22; 144(7):3244-50. PubMed ID: 12810581
    [Abstract] [Full Text] [Related]

  • 11. Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells.
    Miura Y, Matsui H.
    Am J Physiol Endocrinol Metab; 2003 Nov 22; 285(5):E1001-9. PubMed ID: 14534075
    [Abstract] [Full Text] [Related]

  • 12. Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.
    Green BD, Gault VA, Flatt PR, Harriott P, Greer B, O'Harte FP.
    Arch Biochem Biophys; 2004 Aug 15; 428(2):136-43. PubMed ID: 15246869
    [Abstract] [Full Text] [Related]

  • 13. The effects of glucagon-like peptide-I (GLP-I) on hormone secretion from isolated human pancreatic islets.
    Fehmann HC, Hering BJ, Wolf MJ, Brandhorst H, Brandhorst D, Bretzel RG, Federlin K, Göke B.
    Pancreas; 1995 Aug 15; 11(2):196-200. PubMed ID: 7479679
    [Abstract] [Full Text] [Related]

  • 14. Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues.
    Green BD, Gault VA, Mooney MH, Irwin N, Harriott P, Greer B, Bailey CJ, O'Harte FP, Flatt PR.
    Biol Chem; 2004 Feb 15; 385(2):169-77. PubMed ID: 15101559
    [Abstract] [Full Text] [Related]

  • 15. Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1.
    Green BD, Gault VA, Irwin N, Mooney MH, Bailey CJ, Harriott P, Greer B, Flatt PR, O'Harte FP.
    Biol Chem; 2003 Dec 15; 384(12):1543-51. PubMed ID: 14719796
    [Abstract] [Full Text] [Related]

  • 16. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.
    Gromada J, Brock B, Schmitz O, Rorsman P.
    Basic Clin Pharmacol Toxicol; 2004 Dec 15; 95(6):252-62. PubMed ID: 15569269
    [Abstract] [Full Text] [Related]

  • 17. Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta-cells independently of protein kinase A.
    Bode HP, Moormann B, Dabew R, Göke B.
    Endocrinology; 1999 Sep 15; 140(9):3919-27. PubMed ID: 10465260
    [Abstract] [Full Text] [Related]

  • 18. Interaction of GLP-I and leptin at rat pancreatic B-cells: effects on insulin secretion and signal transduction.
    Fehmann HC, Bode HP, Ebert T, Karl A, Göke B.
    Horm Metab Res; 1997 Nov 15; 29(11):572-6. PubMed ID: 9479558
    [Abstract] [Full Text] [Related]

  • 19. Modulation of low-threshold T-type calcium channels by the five muscarinic receptor subtypes in NIH 3T3 cells.
    Pemberton KE, Hill-Eubanks LJ, Jones SV.
    Pflugers Arch; 2000 Jul 15; 440(3):452-61. PubMed ID: 10954332
    [Abstract] [Full Text] [Related]

  • 20. Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro.
    Parkes DG, Pittner R, Jodka C, Smith P, Young A.
    Metabolism; 2001 May 15; 50(5):583-9. PubMed ID: 11319721
    [Abstract] [Full Text] [Related]

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