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464 related items for PubMed ID: 12506115

  • 1. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.
    Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW.
    J Biol Chem; 2003 Mar 07; 278(10):8135-45. PubMed ID: 12506115
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  • 2. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
    Kwak MK, Itoh K, Yamamoto M, Sutter TR, Kensler TW.
    Mol Med; 2001 Feb 07; 7(2):135-45. PubMed ID: 11471548
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  • 9. Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.
    Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR.
    Mol Pharmacol; 2018 Apr 07; 93(4):297-308. PubMed ID: 29367259
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  • 10. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.
    Kwak MK, Itoh K, Yamamoto M, Kensler TW.
    Mol Cell Biol; 2002 May 07; 22(9):2883-92. PubMed ID: 11940647
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  • 11. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
    Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P.
    Proc Natl Acad Sci U S A; 2004 Feb 17; 101(7):2040-5. PubMed ID: 14764894
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  • 12. Targeting NRF2 signaling for cancer chemoprevention.
    Kwak MK, Kensler TW.
    Toxicol Appl Pharmacol; 2010 Apr 01; 244(1):66-76. PubMed ID: 19732782
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  • 13. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.
    Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, Yamamoto M.
    Genes Cells; 2003 Apr 01; 8(4):379-91. PubMed ID: 12653965
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  • 14. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
    Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW.
    Carcinogenesis; 2009 Jun 01; 30(6):1024-31. PubMed ID: 19386581
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  • 15. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
    Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M.
    Nat Genet; 2003 Nov 01; 35(3):238-45. PubMed ID: 14517554
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  • 16. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
    Reisman SA, Yeager RL, Yamamoto M, Klaassen CD.
    Toxicol Sci; 2009 Mar 01; 108(1):35-47. PubMed ID: 19129213
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  • 17. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
    Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S.
    Cancer Res; 2002 Sep 15; 62(18):5196-203. PubMed ID: 12234984
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  • 18. The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
    Zipper LM, Mulcahy RT.
    J Biol Chem; 2002 Sep 27; 277(39):36544-52. PubMed ID: 12145307
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  • 19. Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver.
    Wu KC, Cui JY, Klaassen CD.
    PLoS One; 2012 Sep 27; 7(7):e39006. PubMed ID: 22808024
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  • 20. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.
    Itoh K, Tong KI, Yamamoto M.
    Free Radic Biol Med; 2004 May 15; 36(10):1208-13. PubMed ID: 15110385
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