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155 related items for PubMed ID: 12512868

  • 1. Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens.
    McDorman KS, Wolf DC.
    Toxicol Pathol; 2002; 30(6):675-80. PubMed ID: 12512868
    [Abstract] [Full Text] [Related]

  • 2. Somatic mutation of the tuberous sclerosis (Tsc2) tumor suppressor gene in chemically induced rat renal carcinoma cell.
    Urakami S, Tokuzen R, Tsuda H, Igawa M, Hino O.
    J Urol; 1997 Jul; 158(1):275-8. PubMed ID: 9186374
    [Abstract] [Full Text] [Related]

  • 3. Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model.
    Kikuchi Y, Sudo A, Mitani H, Hino O.
    Int J Oncol; 2004 Jan; 24(1):75-80. PubMed ID: 14654943
    [Abstract] [Full Text] [Related]

  • 4. Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes.
    Toyokuni S, Okada K, Kondo S, Nishioka H, Tanaka T, Nishiyama Y, Hino O, Hiai H.
    Jpn J Cancer Res; 1998 Aug; 89(8):814-20. PubMed ID: 9765616
    [Abstract] [Full Text] [Related]

  • 5. The transcriptional profile of the kidney in Tsc2 heterozygous mutant Long Evans (Eker) rats compared to wild-type.
    Sen B, Wolf DC, Hester SD.
    Mutat Res; 2004 May 18; 549(1-2):213-24. PubMed ID: 15120972
    [Abstract] [Full Text] [Related]

  • 6. Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model.
    Tsuchiya H, Orimoto K, Kobayashi K, Hino O.
    Cancer Res; 1996 Feb 01; 56(3):429-33. PubMed ID: 8564946
    [Abstract] [Full Text] [Related]

  • 7. Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.
    Walker C, Ahn YT, Everitt J, Yuan X.
    Mol Carcinog; 1996 Feb 01; 15(2):154-61. PubMed ID: 8599582
    [Abstract] [Full Text] [Related]

  • 8. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model.
    Sahin K, Cross B, Sahin N, Ciccone K, Suleiman S, Osunkoya AO, Master V, Harris W, Carthon B, Mohammad R, Bilir B, Wertz K, Moreno CS, Walker CL, Kucuk O.
    Arch Biochem Biophys; 2015 Apr 15; 572():36-39. PubMed ID: 25602702
    [Abstract] [Full Text] [Related]

  • 9. Analysis of preneoplastic and neoplastic renal lesions in Tsc2 mutant Long-Evans (Eker) rats following exposure to a mixture of drinking water disinfection by-products.
    McDorman KS, Hooth MJ, Starr TB, Wolf DC.
    Toxicology; 2003 May 01; 187(1):1-12. PubMed ID: 12679048
    [Abstract] [Full Text] [Related]

  • 10. Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.
    Everitt JI, Goldsworthy TL, Wolf DC, Walker CL.
    Toxicol Lett; 1995 Dec 01; 82-83():621-5. PubMed ID: 8597118
    [Abstract] [Full Text] [Related]

  • 11. Estrogen treatment enhances hereditary renal tumor development in Eker rats.
    Wolf DC, Goldsworthy TL, Donner EM, Harden R, Fitzpatrick B, Everitt JI.
    Carcinogenesis; 1998 Nov 01; 19(11):2043-7. PubMed ID: 9855022
    [Abstract] [Full Text] [Related]

  • 12. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat.
    Patel SK, Ma N, Monks TJ, Lau SS.
    Mol Carcinog; 2003 Nov 01; 38(3):141-54. PubMed ID: 14587099
    [Abstract] [Full Text] [Related]

  • 13. Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.
    Orimoto K, Tsuchiya H, Kobayashi T, Matsuda T, Hino O.
    Biochem Biophys Res Commun; 1996 Feb 06; 219(1):70-5. PubMed ID: 8619830
    [Abstract] [Full Text] [Related]

  • 14. Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model.
    Yamashita Y, Yokoyama M, Kobayashi E, Takai S, Hino O.
    Biochem Biophys Res Commun; 2000 Aug 18; 275(1):134-40. PubMed ID: 10944454
    [Abstract] [Full Text] [Related]

  • 15. N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat.
    Satake N, Miyagawa M, Sakurai J, Mitani H, Kobayashi T, Tamura H, Hino O.
    Cancer Lett; 2002 Oct 28; 184(2):157-63. PubMed ID: 12127687
    [Abstract] [Full Text] [Related]

  • 16. TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer.
    Hino O, Fukuda T, Satake N, Kobayashi T, Honda S, Orimoto K, Yamashita Y, Kikuchi Y.
    Prog Exp Tumor Res; 1999 Oct 28; 35():95-108. PubMed ID: 10377754
    [No Abstract] [Full Text] [Related]

  • 17. Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.
    Satake N, Urakami S, Hirayama Y, Izumi K, Hino O.
    Int J Cancer; 1998 Sep 11; 77(6):895-900. PubMed ID: 9714060
    [Abstract] [Full Text] [Related]

  • 18. Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone.
    Lau SS, Monks TJ, Everitt JI, Kleymenova E, Walker CL.
    Chem Res Toxicol; 2001 Jan 11; 14(1):25-33. PubMed ID: 11170505
    [Abstract] [Full Text] [Related]

  • 19. [Cancer genetics of TSC2 gene mutant(Eker) rat model].
    Hino O.
    Nihon Rinsho; 2000 Jun 11; 58(6):1255-61. PubMed ID: 10879050
    [Abstract] [Full Text] [Related]

  • 20. High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats.
    Tanaka T, Iwasa Y, Kondo S, Hiai H, Toyokuni S.
    Oncogene; 1999 Jun 24; 18(25):3793-7. PubMed ID: 10391689
    [Abstract] [Full Text] [Related]

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