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633 related items for PubMed ID: 12520087
1. GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells. Annerén C, Welsh M. Mol Med; 2002 Nov; 8(11):705-13. PubMed ID: 12520087 [Abstract] [Full Text] [Related]
2. Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins. Welsh N, Makeeva N, Welsh M. Mol Med; 2002 Nov; 8(11):695-704. PubMed ID: 12520086 [Abstract] [Full Text] [Related]
3. Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK. Annerén C, Welsh M. Mol Med; 2001 May; 7(5):301-10. PubMed ID: 11474576 [Abstract] [Full Text] [Related]
4. nitric oxide triggers the phosphatidylinositol 3-kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1. Tejedo JR, Cahuana GM, Ramírez R, Esbert M, Jiménez J, Sobrino F, Bedoya FJ. Endocrinology; 2004 May; 145(5):2319-27. PubMed ID: 14764634 [Abstract] [Full Text] [Related]
5. Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, Rhodes CJ. Diabetes; 2002 Apr; 51(4):966-76. PubMed ID: 11916914 [Abstract] [Full Text] [Related]
6. Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin. Annerén C. J Endocrinol; 2002 Jan; 172(1):145-53. PubMed ID: 11786382 [Abstract] [Full Text] [Related]
7. Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart. Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F. Diabetes; 2001 Dec; 50(12):2709-20. PubMed ID: 11723053 [Abstract] [Full Text] [Related]
8. Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Cousin SP, Hügl SR, Myers MG, White MF, Reifel-Miller A, Rhodes CJ. Biochem J; 1999 Dec 15; 344 Pt 3(Pt 3):649-58. PubMed ID: 10585851 [Abstract] [Full Text] [Related]
9. IRS-1 tyrosine phosphorylation reflects insulin-induced metabolic and mitogenic responses in 3T3-L1 pre-adipocytes. Telting D, van der Zon GC, Dorrestijn J, Maassen JA. Arch Physiol Biochem; 2001 Feb 15; 109(1):52-62. PubMed ID: 11471071 [Abstract] [Full Text] [Related]
10. Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells. Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G. Circ Res; 2004 May 14; 94(9):1211-8. PubMed ID: 15044323 [Abstract] [Full Text] [Related]
11. Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes. Mur C, Valverde AM, Kahn CR, Benito M. Diabetes; 2002 Mar 14; 51(3):743-54. PubMed ID: 11872675 [Abstract] [Full Text] [Related]
12. The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation. Annerén C, Lindholm CK, Kriz V, Welsh M. Curr Mol Med; 2003 Jun 14; 3(4):313-24. PubMed ID: 12776987 [Abstract] [Full Text] [Related]
13. Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts. Conejo R, Lorenzo M. J Cell Physiol; 2001 Apr 14; 187(1):96-108. PubMed ID: 11241354 [Abstract] [Full Text] [Related]
14. Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1/PI 3-kinase/AKT pathway. del Rincón SV, Rousseau C, Samanta R, Miller WH. Oncogene; 2003 May 29; 22(22):3353-60. PubMed ID: 12776186 [Abstract] [Full Text] [Related]
15. Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells. Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N. Mol Med; 1999 Mar 29; 5(3):169-80. PubMed ID: 10404514 [Abstract] [Full Text] [Related]
16. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells. Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G. Endocrinology; 2004 Jun 29; 145(6):2845-57. PubMed ID: 15001544 [Abstract] [Full Text] [Related]
17. GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase. Annerén C, Reedquist KA, Bos JL, Welsh M. J Biol Chem; 2000 Sep 15; 275(37):29153-61. PubMed ID: 10878015 [Abstract] [Full Text] [Related]
18. Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Bartucci M, Morelli C, Mauro L, Andò S, Surmacz E. Cancer Res; 2001 Sep 15; 61(18):6747-54. PubMed ID: 11559546 [Abstract] [Full Text] [Related]
19. Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells. Hennige AM, Lammers R, Arlt D, Höppner W, Strack V, Niederfellner G, Seif FJ, Häring HU, Kellerer M. Mol Cell Endocrinol; 2000 Sep 25; 167(1-2):69-76. PubMed ID: 11000521 [Abstract] [Full Text] [Related]
20. Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway. Kurihara S, Hakuno F, Takahashi S. Endocr J; 2000 Dec 25; 47(6):739-51. PubMed ID: 11228049 [Abstract] [Full Text] [Related] Page: [Next] [New Search]