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714 related items for PubMed ID: 12521378

  • 1. Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling.
    Ahmed Z, Pillay TS.
    Biochem J; 2003 Apr 15; 371(Pt 2):405-12. PubMed ID: 12521378
    [Abstract] [Full Text] [Related]

  • 2. Insulin increase in MAP kinase phosphorylation is shifted to early time-points by overexpressing APS, while Akt phosphorylation is not influenced.
    Onnockx S, Xie J, Degraef C, Erneux C, Pirson I.
    Exp Cell Res; 2009 Sep 10; 315(15):2479-86. PubMed ID: 19527711
    [Abstract] [Full Text] [Related]

  • 3. Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
    Batty IH, Fleming IN, Downes CP.
    Biochem J; 2004 May 01; 379(Pt 3):641-51. PubMed ID: 14769130
    [Abstract] [Full Text] [Related]

  • 4. Insulin receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1.
    Zhang M, Riedel H.
    J Cell Biochem; 2009 May 01; 107(1):65-75. PubMed ID: 19277985
    [Abstract] [Full Text] [Related]

  • 5. Association of insulin receptor substrate 3 with SH2 domain-containing proteins in rat adipocytes.
    Ross SA, Lienhard GE, Lavan BE.
    Biochem Biophys Res Commun; 1998 Jun 18; 247(2):487-92. PubMed ID: 9642156
    [Abstract] [Full Text] [Related]

  • 6. Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells.
    Banno Y, Takuwa Y, Yamada M, Takuwa N, Ohguchi K, Hara A, Nozawa Y.
    Biochem J; 2003 Jan 15; 369(Pt 2):363-8. PubMed ID: 12385647
    [Abstract] [Full Text] [Related]

  • 7. Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways.
    Sorokin A, Reed E, Nnkemere N, Dulin NO, Schlessinger J.
    Oncogene; 1998 May 14; 16(19):2425-34. PubMed ID: 9627109
    [Abstract] [Full Text] [Related]

  • 8. Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.
    Hu J, Hubbard SR.
    J Mol Biol; 2006 Aug 04; 361(1):69-79. PubMed ID: 16824542
    [Abstract] [Full Text] [Related]

  • 9. D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells.
    Zhen X, Zhang J, Johnson GP, Friedman E.
    Mol Pharmacol; 2001 Oct 04; 60(4):857-64. PubMed ID: 11562449
    [Abstract] [Full Text] [Related]

  • 10. An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
    Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL.
    Diabetologia; 2002 May 04; 45(5):657-67. PubMed ID: 12107746
    [Abstract] [Full Text] [Related]

  • 11. Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: potential role of the NFkappa B pathway.
    Ismail WI, King JA, Anwar K, Pillay TS.
    J Cell Biochem; 2013 Aug 04; 114(8):1729-37. PubMed ID: 23386514
    [Abstract] [Full Text] [Related]

  • 12. Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins.
    Hemming R, Agatep R, Badiani K, Wyant K, Arthur G, Gietz RD, Triggs-Raine B.
    Biochem Cell Biol; 2001 Aug 04; 79(1):21-32. PubMed ID: 11235915
    [Abstract] [Full Text] [Related]

  • 13. Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1.
    Falcone S, Mauro L, de Rose G, Paolucci C, Sciorati C, Ando S, Clementi E.
    Biochem J; 2002 Aug 15; 366(Pt 1):165-73. PubMed ID: 11978177
    [Abstract] [Full Text] [Related]

  • 14. Effect of phosphotyrosyl-IRS-1 level and insulin receptor tyrosine kinase activity on insulin-stimulated phosphatidylinositol 3, MAP, and S6 kinase activities.
    Wilden PA, Broadway DE.
    J Cell Physiol; 1995 Apr 15; 163(1):9-18. PubMed ID: 7896903
    [Abstract] [Full Text] [Related]

  • 15. Functional effects of APS and SH2-B on insulin receptor signalling.
    Ahmed Z, Pillay TS.
    Biochem Soc Trans; 2001 Aug 15; 29(Pt 4):529-34. PubMed ID: 11498022
    [Abstract] [Full Text] [Related]

  • 16. Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.
    Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y.
    Am J Physiol Endocrinol Metab; 2002 Jun 15; 282(6):E1385-94. PubMed ID: 12006370
    [Abstract] [Full Text] [Related]

  • 17. A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
    Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ.
    Nature; 1996 Feb 08; 379(6565):560-4. PubMed ID: 8596638
    [Abstract] [Full Text] [Related]

  • 18. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
    Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A.
    Oncogene; 1997 Jul 03; 15(1):7-15. PubMed ID: 9233773
    [Abstract] [Full Text] [Related]

  • 19. Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.
    Hers I, Tavaré JM.
    Biochem J; 2005 Jun 01; 388(Pt 2):713-20. PubMed ID: 15713122
    [Abstract] [Full Text] [Related]

  • 20. The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation.
    Sentinelli F, Filippi E, Cavallo MG, Romeo S, Fanelli M, Baroni MG.
    J Endocrinol; 2006 Feb 01; 188(2):271-85. PubMed ID: 16461553
    [Abstract] [Full Text] [Related]

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