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314 related items for PubMed ID: 12526674

  • 1. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
    Anderson RF, Shinde SS, Hay MP, Gamage SA, Denny WA.
    J Am Chem Soc; 2003 Jan 22; 125(3):748-56. PubMed ID: 12526674
    [Abstract] [Full Text] [Related]

  • 2. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Shinde SS, Anderson RF, Hay MP, Gamage SA, Denny WA.
    J Am Chem Soc; 2004 Jun 30; 126(25):7865-74. PubMed ID: 15212534
    [Abstract] [Full Text] [Related]

  • 3. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
    Anderson RF, Shinde SS, Hay MP, Denny WA.
    J Am Chem Soc; 2006 Jan 11; 128(1):245-9. PubMed ID: 16390153
    [Abstract] [Full Text] [Related]

  • 4. Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Anderson RF, Shinde SS, Hay MP, Gamage SA, Denny WA.
    Org Biomol Chem; 2005 Jun 07; 3(11):2167-74. PubMed ID: 15917906
    [Abstract] [Full Text] [Related]

  • 5. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Shinde SS, Maroz A, Hay MP, Patterson AV, Denny WA, Anderson RF.
    J Am Chem Soc; 2010 Mar 03; 132(8):2591-9. PubMed ID: 20141134
    [Abstract] [Full Text] [Related]

  • 6. Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase.
    Shinde SS, Hay MP, Patterson AV, Denny WA, Anderson RF.
    J Am Chem Soc; 2009 Oct 14; 131(40):14220-1. PubMed ID: 19772319
    [Abstract] [Full Text] [Related]

  • 7. Effect of pH on one-electron oxidation chemistry of organoselenium compounds in aqueous solutions.
    Mishra B, Priyadarsini KI, Mohan H.
    J Phys Chem A; 2006 Feb 09; 110(5):1894-900. PubMed ID: 16451022
    [Abstract] [Full Text] [Related]

  • 8. Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical.
    Lloyd RV, Duling DR, Rumyantseva GV, Mason RP, Bridson PK.
    Mol Pharmacol; 1991 Sep 09; 40(3):440-5. PubMed ID: 1654517
    [Abstract] [Full Text] [Related]

  • 9. Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs.
    Wardman P, Priyadarsini KI, Dennis MF, Everett SA, Naylor MA, Patel KB, Stratford IJ, Stratford MR, Tracy M.
    Br J Cancer Suppl; 1996 Jul 09; 27():S70-4. PubMed ID: 8763850
    [Abstract] [Full Text] [Related]

  • 10. DNA lesions derived from the site selective oxidation of Guanine by carbonate radical anions.
    Joffe A, Geacintov NE, Shafirovich V.
    Chem Res Toxicol; 2003 Dec 09; 16(12):1528-38. PubMed ID: 14680366
    [Abstract] [Full Text] [Related]

  • 11. Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues.
    Inbaraj JJ, Motten AG, Chignell CF.
    Chem Res Toxicol; 2003 Feb 09; 16(2):164-70. PubMed ID: 12588187
    [Abstract] [Full Text] [Related]

  • 12. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
    Junnotula V, Sarkar U, Sinha S, Gates KS.
    J Am Chem Soc; 2009 Jan 28; 131(3):1015-24. PubMed ID: 19117394
    [Abstract] [Full Text] [Related]

  • 13. Time-resolved FT EPR and optical spectroscopy study on photooxidation of aliphatic alpha-amino acids in aqueous solutions; electron transfer from amino vs carboxylate functional group.
    Tarabek P, Bonifacić M, Beckert D.
    J Phys Chem A; 2006 Jun 08; 110(22):7293-302. PubMed ID: 16737283
    [Abstract] [Full Text] [Related]

  • 14. Electron and spin-density analysis of tirapazamine reduction chemistry.
    Yin J, Glaser R, Gates KS.
    Chem Res Toxicol; 2012 Mar 19; 25(3):620-33. PubMed ID: 22390194
    [Abstract] [Full Text] [Related]

  • 15. Reactions of hydroxyl radical with bergenin, a natural poly phenol studied by pulse radiolysis.
    Singh U, Barik A, Priyadarsini KI.
    Bioorg Med Chem; 2009 Aug 15; 17(16):6008-14. PubMed ID: 19608422
    [Abstract] [Full Text] [Related]

  • 16. Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one).
    Lin M, Katsumura Y, Hata K, Muroya Y, Nakagawa K.
    J Photochem Photobiol B; 2007 Nov 12; 89(1):36-43. PubMed ID: 17822914
    [Abstract] [Full Text] [Related]

  • 17. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
    Hwang JT, Greenberg MM, Fuchs T, Gates KS.
    Biochemistry; 1999 Oct 26; 38(43):14248-55. PubMed ID: 10571998
    [Abstract] [Full Text] [Related]

  • 18. On the reaction mechanism of tirapazamine reduction chemistry: unimolecular N-OH homolysis, stepwise dehydration, or triazene ring-opening.
    Yin J, Glaser R, Gates KS.
    Chem Res Toxicol; 2012 Mar 19; 25(3):634-45. PubMed ID: 22390168
    [Abstract] [Full Text] [Related]

  • 19. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
    [Abstract] [Full Text] [Related]

  • 20. Formation of a sandwich-structure assisted, relatively long-lived sulfur-centered three-electron bonded radical anion in the reduction of a bis(1-substituted-uracilyl) disulfide in aqueous solution.
    Wenska G, Filipiak P, Asmus KD, Bobrowski K, Koput J, Marciniak B.
    J Phys Chem B; 2008 Aug 14; 112(32):10045-53. PubMed ID: 18646807
    [Abstract] [Full Text] [Related]

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