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Journal Abstract Search

133 related items for PubMed ID: 12542971

  • 1. Activation of dihaloalkanes by thiol-dependent mechanisms.
    Guengerich FP.
    J Biochem Mol Biol; 2003 Jan 31; 36(1):20-7. PubMed ID: 12542971
    [Abstract] [Full Text] [Related]

  • 2. Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
    Guengerich FP.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):369-78. PubMed ID: 15581593
    [Abstract] [Full Text] [Related]

  • 3. Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts.
    Guengerich FP, Peterson LA, Cmarik JL, Koga N, Inskeep PB.
    Environ Health Perspect; 1987 Dec 15; 76():15-8. PubMed ID: 3329096
    [Abstract] [Full Text] [Related]

  • 4. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
    Cho SH, Guengerich FP.
    Chem Res Toxicol; 2013 Nov 18; 26(11):1765-74. PubMed ID: 24191644
    [Abstract] [Full Text] [Related]

  • 5. Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
    Thier R, Taylor JB, Pemble SE, Humphreys WG, Persmark M, Ketterer B, Guengerich FP.
    Proc Natl Acad Sci U S A; 1993 Sep 15; 90(18):8576-80. PubMed ID: 8378332
    [Abstract] [Full Text] [Related]

  • 6. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
    Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP.
    Chem Res Toxicol; 2004 Jul 15; 17(7):972-82. PubMed ID: 15257623
    [Abstract] [Full Text] [Related]

  • 7. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
    Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE.
    Chem Res Toxicol; 2007 Jan 15; 20(1):155-63. PubMed ID: 17226938
    [Abstract] [Full Text] [Related]

  • 8. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
    Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE.
    J Biol Chem; 2004 Feb 06; 279(6):4250-9. PubMed ID: 14645247
    [Abstract] [Full Text] [Related]

  • 9. A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system.
    Oda Y, Yamazaki H, Thier R, Ketterer B, Guengerich FP, Shimada T.
    Carcinogenesis; 1996 Feb 06; 17(2):297-302. PubMed ID: 8625454
    [Abstract] [Full Text] [Related]

  • 10. Structures of DNA adducts formed by halothioketenes and haloketenes: possible adducts formed from trichloro- and perchloroethene via glutathione conjugation.
    Müller M, Birner G, Henschler D, Dekant W.
    IARC Sci Publ; 1994 Feb 06; (125):423-8. PubMed ID: 7806332
    [No Abstract] [Full Text] [Related]

  • 11. Bioactivation of halogenated hydrocarbons.
    Anders MW.
    J Toxicol Clin Toxicol; 1982 Aug 06; 19(6-7):699-706. PubMed ID: 7161850
    [Abstract] [Full Text] [Related]

  • 12. Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
    Loecken EM, Guengerich FP.
    Chem Res Toxicol; 2008 Feb 06; 21(2):453-8. PubMed ID: 18163542
    [Abstract] [Full Text] [Related]

  • 13. Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA.
    Ghodke PP, Matse JH, Dawson S, Guengerich FP.
    Chem Res Toxicol; 2022 Oct 17; 35(10):1805-1808. PubMed ID: 35482010
    [Abstract] [Full Text] [Related]

  • 14. Covalent binding of 1,2-dihaloalkanes to DNA and stability of the major DNA adduct, S-[2-(N7-guanyl)ethyl]glutathione.
    Inskeep PB, Koga N, Cmarik JL, Guengerich FP.
    Cancer Res; 1986 Jun 17; 46(6):2839-44. PubMed ID: 2870801
    [Abstract] [Full Text] [Related]

  • 15. Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione.
    Kim MS, Guengerich FP.
    Chem Res Toxicol; 1998 Apr 17; 11(4):311-6. PubMed ID: 9548801
    [Abstract] [Full Text] [Related]

  • 16. Dihaloalkanes and polyhaloalkenes.
    Guengerich FP, Min KS, Persmark M, Kim MS, Humphreys WG, Cmarik JM, Thier R.
    IARC Sci Publ; 1994 Apr 17; (125):57-72. PubMed ID: 7806341
    [No Abstract] [Full Text] [Related]

  • 17. Metabolism and covalent binding of vic-dihaloalkanes, vinyl halides and acrylonitrile.
    Guengerich FP, Hogy LL, Inskeep PB, Liebler DC.
    IARC Sci Publ; 1986 Apr 17; (70):255-60. PubMed ID: 3793176
    [Abstract] [Full Text] [Related]

  • 18. Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts.
    Krokan H, Grafstrom RC, Sundqvist K, Esterbauer H, Harris CC.
    Carcinogenesis; 1985 Dec 17; 6(12):1755-9. PubMed ID: 4064250
    [Abstract] [Full Text] [Related]

  • 19. Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates.
    Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP.
    Chem Res Toxicol; 2007 Nov 17; 20(11):1594-600. PubMed ID: 17907789
    [Abstract] [Full Text] [Related]

  • 20. Metabolism and genotoxicity of dihaloalkanes.
    Guengerich FP.
    Adv Pharmacol; 1994 Nov 17; 27():211-36. PubMed ID: 8068554
    [No Abstract] [Full Text] [Related]

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