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364 related items for PubMed ID: 12552097

  • 1. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
    Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD.
    Proc Natl Acad Sci U S A; 2003 Feb 04; 100(3):940-5. PubMed ID: 12552097
    [Abstract] [Full Text] [Related]

  • 2. RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
    Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD.
    J Biol Chem; 2005 Sep 30; 280(39):33178-89. PubMed ID: 16030021
    [Abstract] [Full Text] [Related]

  • 3. Beta-arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of beta2-adrenoceptor signalling to activation of ERK.
    Houslay MD, Baillie GS.
    Biochem Soc Trans; 2005 Dec 30; 33(Pt 6):1333-6. PubMed ID: 16246112
    [Abstract] [Full Text] [Related]

  • 4. Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
    Baillie GS, Adams DR, Bhari N, Houslay TM, Vadrevu S, Meng D, Li X, Dunlop A, Milligan G, Bolger GB, Klussmann E, Houslay MD.
    Biochem J; 2007 May 15; 404(1):71-80. PubMed ID: 17288540
    [Abstract] [Full Text] [Related]

  • 5. Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
    Li X, Huston E, Lynch MJ, Houslay MD, Baillie GS.
    Biochem J; 2006 Mar 01; 394(Pt 2):427-35. PubMed ID: 16356165
    [Abstract] [Full Text] [Related]

  • 6. Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
    Bolger GB, Baillie GS, Li X, Lynch MJ, Herzyk P, Mohamed A, Mitchell LH, McCahill A, Hundsrucker C, Klussmann E, Adams DR, Houslay MD.
    Biochem J; 2006 Aug 15; 398(1):23-36. PubMed ID: 16689683
    [Abstract] [Full Text] [Related]

  • 7. cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.
    Lynch MJ, Baillie GS, Houslay MD.
    Biochem Soc Trans; 2007 Nov 15; 35(Pt 5):938-41. PubMed ID: 17956250
    [Abstract] [Full Text] [Related]

  • 8. Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
    MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD.
    Br J Pharmacol; 2002 Jun 15; 136(3):421-33. PubMed ID: 12023945
    [Abstract] [Full Text] [Related]

  • 9. 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
    Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, Houslay MD.
    Cell Signal; 2007 Dec 15; 19(12):2612-24. PubMed ID: 17900862
    [Abstract] [Full Text] [Related]

  • 10. The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.
    Houslay MD, Baillie GS.
    Biochem Soc Trans; 2003 Dec 15; 31(Pt 6):1186-90. PubMed ID: 14641023
    [Abstract] [Full Text] [Related]

  • 11. Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation.
    Houslay MD, Baillie GS.
    Biochem Soc Trans; 2006 Aug 15; 34(Pt 4):474-5. PubMed ID: 16856836
    [Abstract] [Full Text] [Related]

  • 12. Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
    Terry R, Cheung YF, Praestegaard M, Baillie GS, Huston E, Gall I, Adams DR, Houslay MD.
    Cell Signal; 2003 Oct 15; 15(10):955-71. PubMed ID: 12873709
    [Abstract] [Full Text] [Related]

  • 13. The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.
    Ong WK, Gribble FM, Reimann F, Lynch MJ, Houslay MD, Baillie GS, Furman BL, Pyne NJ.
    Br J Pharmacol; 2009 Jun 15; 157(4):633-44. PubMed ID: 19371330
    [Abstract] [Full Text] [Related]

  • 14. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
    Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ.
    J Biol Chem; 2006 Jan 13; 281(2):1261-73. PubMed ID: 16280323
    [Abstract] [Full Text] [Related]

  • 15. Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.
    Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.
    Cell Signal; 2009 May 13; 21(5):760-6. PubMed ID: 19167487
    [Abstract] [Full Text] [Related]

  • 16. Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).
    Baillie G, MacKenzie SJ, Houslay MD.
    Mol Pharmacol; 2001 Nov 13; 60(5):1100-11. PubMed ID: 11641439
    [Abstract] [Full Text] [Related]

  • 17. Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
    Li X, Baillie GS, Houslay MD.
    J Biol Chem; 2009 Jun 12; 284(24):16170-16182. PubMed ID: 19372219
    [Abstract] [Full Text] [Related]

  • 18. In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
    McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD.
    Cell Signal; 2005 Sep 12; 17(9):1158-73. PubMed ID: 15905070
    [Abstract] [Full Text] [Related]

  • 19. Reciprocal regulation of calcium dependent and calcium independent cyclic AMP hydrolysis by protein phosphorylation.
    Ang KL, Antoni FA.
    J Neurochem; 2002 May 12; 81(3):422-33. PubMed ID: 12065651
    [Abstract] [Full Text] [Related]

  • 20. Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes.
    Baillie GS, Houslay MD.
    Curr Opin Cell Biol; 2005 Apr 12; 17(2):129-34. PubMed ID: 15780588
    [Abstract] [Full Text] [Related]

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