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260 related items for PubMed ID: 12556448

  • 1. Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).
    Henderson C, Mizzau M, Paroni G, Maestro R, Schneider C, Brancolini C.
    J Biol Chem; 2003 Apr 04; 278(14):12579-89. PubMed ID: 12556448
    [Abstract] [Full Text] [Related]

  • 2. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
    Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW.
    Proc Natl Acad Sci U S A; 2001 Sep 11; 98(19):10833-8. PubMed ID: 11535817
    [Abstract] [Full Text] [Related]

  • 3. Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
    Almenara J, Rosato R, Grant S.
    Leukemia; 2002 Jul 11; 16(7):1331-43. PubMed ID: 12094258
    [Abstract] [Full Text] [Related]

  • 4. The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells.
    Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, Schuppan D.
    J Hepatol; 2002 Feb 11; 36(2):233-40. PubMed ID: 11830335
    [Abstract] [Full Text] [Related]

  • 5. Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells.
    Gillenwater AM, Zhong M, Lotan R.
    Mol Cancer Ther; 2007 Nov 11; 6(11):2967-75. PubMed ID: 18025281
    [Abstract] [Full Text] [Related]

  • 6. Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.
    Dong G, Luo J, Kumar V, Dong Z.
    Am J Physiol Renal Physiol; 2010 Feb 11; 298(2):F293-300. PubMed ID: 19889954
    [Abstract] [Full Text] [Related]

  • 7. Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis.
    Fischer B, Coelho D, Dufour P, Bergerat JP, Denis JM, Gueulette J, Bischoff P.
    Biochem Biophys Res Commun; 2003 Jun 27; 306(2):516-22. PubMed ID: 12804595
    [Abstract] [Full Text] [Related]

  • 8. Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
    Jang ER, Kim YJ, Myung SC, Kim W, Lee CS.
    Mol Cell Biochem; 2011 Jul 27; 353(1-2):1-11. PubMed ID: 21380726
    [Abstract] [Full Text] [Related]

  • 9. The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells.
    Ocker M, Alajati A, Ganslmayer M, Zopf S, Lüders M, Neureiter D, Hahn EG, Schuppan D, Herold C.
    J Cancer Res Clin Oncol; 2005 Jun 27; 131(6):385-94. PubMed ID: 15754201
    [Abstract] [Full Text] [Related]

  • 10. Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents.
    Dong G, Wang L, Wang CY, Yang T, Kumar MV, Dong Z.
    J Pharmacol Exp Ther; 2008 Jun 27; 325(3):978-84. PubMed ID: 18310471
    [Abstract] [Full Text] [Related]

  • 11. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors.
    Shao Y, Gao Z, Marks PA, Jiang X.
    Proc Natl Acad Sci U S A; 2004 Dec 28; 101(52):18030-5. PubMed ID: 15596714
    [Abstract] [Full Text] [Related]

  • 12. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release.
    Slee EA, Keogh SA, Martin SJ.
    Cell Death Differ; 2000 Jun 28; 7(6):556-65. PubMed ID: 10822279
    [Abstract] [Full Text] [Related]

  • 13. The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells.
    Zhang XD, Gillespie SK, Borrow JM, Hersey P.
    Mol Cancer Ther; 2004 Apr 28; 3(4):425-35. PubMed ID: 15078986
    [Abstract] [Full Text] [Related]

  • 14. Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure.
    Qiu X, Rong X, Yang J, Lu Y.
    BMC Ophthalmol; 2019 Feb 04; 19(1):42. PubMed ID: 30717701
    [Abstract] [Full Text] [Related]

  • 15. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors.
    Bossy-Wetzel E, Green DR.
    J Biol Chem; 1999 Jun 18; 274(25):17484-90. PubMed ID: 10364179
    [Abstract] [Full Text] [Related]

  • 16. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells.
    Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M, Sakai T.
    Oncogene; 2004 Aug 19; 23(37):6261-71. PubMed ID: 15208660
    [Abstract] [Full Text] [Related]

  • 17. The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells.
    Park KC, Heo JH, Jeon JY, Choi HJ, Jo AR, Kim SW, Kwon HJ, Hong SJ, Han KS.
    BMC Cancer; 2015 Jan 23; 15():19. PubMed ID: 25613585
    [Abstract] [Full Text] [Related]

  • 18. Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells.
    Choi YH.
    Int J Oncol; 2005 Aug 23; 27(2):473-9. PubMed ID: 16010430
    [Abstract] [Full Text] [Related]

  • 19. Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells.
    You BR, Han BR, Park WH.
    Oncotarget; 2017 Mar 14; 8(11):17726-17737. PubMed ID: 28099148
    [Abstract] [Full Text] [Related]

  • 20. Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathway.
    Oh SH, Lee BH, Lim SC.
    Biochem Pharmacol; 2004 Nov 01; 68(9):1845-55. PubMed ID: 15450950
    [Abstract] [Full Text] [Related]

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