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505 related items for PubMed ID: 12588189

  • 1. Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA.
    Upadhyaya P, Sturla SJ, Tretyakova N, Ziegel R, Villalta PW, Wang M, Hecht SS.
    Chem Res Toxicol; 2003 Feb; 16(2):180-90. PubMed ID: 12588189
    [Abstract] [Full Text] [Related]

  • 2. Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA.
    Hecht SS, Villalta PW, Sturla SJ, Cheng G, Yu N, Upadhyaya P, Wang M.
    Chem Res Toxicol; 2004 May; 17(5):588-97. PubMed ID: 15144215
    [Abstract] [Full Text] [Related]

  • 3. Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens.
    Wang M, Cheng G, Sturla SJ, Shi Y, McIntee EJ, Villalta PW, Upadhyaya P, Hecht SS.
    Chem Res Toxicol; 2003 May; 16(5):616-26. PubMed ID: 12755591
    [Abstract] [Full Text] [Related]

  • 4. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Upadhyaya P, Kalscheuer S, Hochalter JB, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2008 Jul; 21(7):1468-76. PubMed ID: 18570389
    [Abstract] [Full Text] [Related]

  • 5. Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine.
    Thomson NM, Mijal RS, Ziegel R, Fleischer NL, Pegg AE, Tretyakova NY, Peterson LA.
    Chem Res Toxicol; 2004 Dec; 17(12):1600-6. PubMed ID: 15606135
    [Abstract] [Full Text] [Related]

  • 6. Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
    Lao Y, Villalta PW, Sturla SJ, Wang M, Hecht SS.
    Chem Res Toxicol; 2006 May; 19(5):674-82. PubMed ID: 16696570
    [Abstract] [Full Text] [Related]

  • 7. Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Sturla SJ, Scott J, Lao Y, Hecht SS, Villalta PW.
    Chem Res Toxicol; 2005 Jun; 18(6):1048-55. PubMed ID: 15962940
    [Abstract] [Full Text] [Related]

  • 8. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2007 Feb; 20(2):235-45. PubMed ID: 17305407
    [Abstract] [Full Text] [Related]

  • 9. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Zhang S, Wang M, Villalta PW, Lindgren BR, Upadhyaya P, Lao Y, Hecht SS.
    Chem Res Toxicol; 2009 May; 22(5):926-36. PubMed ID: 19358518
    [Abstract] [Full Text] [Related]

  • 10. Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
    Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS.
    Carcinogenesis; 2014 Dec; 35(12):2798-806. PubMed ID: 25269804
    [Abstract] [Full Text] [Related]

  • 11. Analysis and Identification of 2'-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Carlson ES, Upadhyaya P, Villalta PW, Ma B, Hecht SS.
    Chem Res Toxicol; 2018 May 21; 31(5):358-370. PubMed ID: 29651838
    [Abstract] [Full Text] [Related]

  • 12. Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).
    Cheng G, Wang M, Upadhyaya P, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2008 Mar 21; 21(3):746-51. PubMed ID: 18205321
    [Abstract] [Full Text] [Related]

  • 13. Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA.
    Upadhyaya P, McIntee EJ, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2006 Mar 21; 19(3):426-35. PubMed ID: 16544948
    [Abstract] [Full Text] [Related]

  • 14. Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links.
    Cheng G, Shi Y, Sturla SJ, Jalas JR, McIntee EJ, Villalta PW, Wang M, Hecht SS.
    Chem Res Toxicol; 2003 Feb 21; 16(2):145-52. PubMed ID: 12588185
    [Abstract] [Full Text] [Related]

  • 15. Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Stepanov I, Hecht SS.
    Chem Res Toxicol; 2009 Feb 21; 22(2):406-14. PubMed ID: 19166332
    [Abstract] [Full Text] [Related]

  • 16. Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.
    Chem Res Toxicol; 2018 Jan 16; 31(1):48-57. PubMed ID: 29131934
    [Abstract] [Full Text] [Related]

  • 17. The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.
    Thomson NM, Kenney PM, Peterson LA.
    Chem Res Toxicol; 2003 Jan 16; 16(1):1-6. PubMed ID: 12693024
    [Abstract] [Full Text] [Related]

  • 18. Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences.
    Rajesh M, Wang G, Jones R, Tretyakova N.
    Biochemistry; 2005 Feb 15; 44(6):2197-207. PubMed ID: 15697245
    [Abstract] [Full Text] [Related]

  • 19. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.
    Wang L, Spratt TE, Liu XK, Hecht SS, Pegg AE, Peterson LA.
    Chem Res Toxicol; 1997 May 15; 10(5):562-7. PubMed ID: 9168254
    [Abstract] [Full Text] [Related]

  • 20. Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.
    Liu Z, Young-Sciame R, Hecht SS.
    Chem Res Toxicol; 1996 Jun 15; 9(4):774-80. PubMed ID: 8831822
    [Abstract] [Full Text] [Related]

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