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Pubmed for Handhelds

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Journal Abstract Search

192 related items for PubMed ID: 12588191

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  • 7. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
    Tang C, Subramanian R, Kuo Y, Krymgold S, Lu P, Kuduk SD, Ng C, Feng DM, Elmore C, Soli E, Ho J, Bock MG, Baillie TA, Prueksaritanont T.
    Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
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  • 14. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
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  • 15. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
    Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC.
    Rapid Commun Mass Spectrom; 2008 Apr; 22(8):1295-311. PubMed ID: 18383206
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  • 16. Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
    Samuel K, Yin W, Stearns RA, Tang YS, Chaudhary AG, Jewell JP, Lanza T, Lin LS, Hagmann WK, Evans DC, Kumar S.
    J Mass Spectrom; 2003 Feb; 38(2):211-21. PubMed ID: 12577288
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  • 17. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC, Vashishtha SC, DeMaio W, Talaat RE.
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
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  • 18. In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide.
    Lin CC, Wong BK, Burgey CS, Gibson CR, Singh R.
    J Pharm Biomed Anal; 2005 Oct 04; 39(5):1014-20. PubMed ID: 16023819
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  • 19. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
    Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, Zhu X, Li C.
    Chem Res Toxicol; 2010 Mar 15; 23(3):653-63. PubMed ID: 20095585
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  • 20. Delineating novel metabolic pathways of DPC 963, a non-nucleoside reverse transcriptase inhibitor, in rats. Characterization of glutathione conjugates of postulated oxirene and benzoquinone imine intermediates by LC/MS and LC/NMR.
    Chen H, Shockcor J, Chen W, Espina R, Gan LS, Mutlib AE.
    Chem Res Toxicol; 2002 Mar 15; 15(3):388-99. PubMed ID: 11896687
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