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345 related items for PubMed ID: 12593670

  • 1. Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.
    Fairlie WD, De Souza D, Nicola NA, Baca M.
    Biochem J; 2003 Jun 01; 372(Pt 2):495-502. PubMed ID: 12593670
    [Abstract] [Full Text] [Related]

  • 2. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
    Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F.
    J Biol Chem; 2003 Jan 03; 278(1):661-71. PubMed ID: 12403768
    [Abstract] [Full Text] [Related]

  • 3. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
    Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F.
    J Biol Chem; 2000 Apr 28; 275(17):12848-56. PubMed ID: 10777583
    [Abstract] [Full Text] [Related]

  • 4. TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex.
    Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D.
    J Immunol; 2003 Jul 01; 171(1):257-66. PubMed ID: 12817006
    [Abstract] [Full Text] [Related]

  • 5. Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
    Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F.
    J Immunol; 2000 Sep 01; 165(5):2535-43. PubMed ID: 10946280
    [Abstract] [Full Text] [Related]

  • 6. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
    Schaper F, Gendo C, Eck M, Schmitz J, Grimm C, Anhuf D, Kerr IM, Heinrich PC.
    Biochem J; 1998 Nov 01; 335 ( Pt 3)(Pt 3):557-65. PubMed ID: 9794795
    [Abstract] [Full Text] [Related]

  • 7. The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.
    Clahsen T, Lehmann U, Stross C, Hermanns HM, Volkmer-Engert R, Schneider-Mergener J, Heinrich PC, Schaper F.
    Cell Signal; 2005 May 01; 17(5):559-69. PubMed ID: 15683731
    [Abstract] [Full Text] [Related]

  • 8. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
    Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Müller-Newen G, Heinrich PC, Schaper F.
    Biochem J; 2004 Mar 01; 378(Pt 2):449-60. PubMed ID: 14611646
    [Abstract] [Full Text] [Related]

  • 9. Desensitization of signaling by oncostatin M in human vascular cells involves cytoplasmic Tyr residue 759 in gp130 but is not mediated by either Src homology 2 domain-containing tyrosine phosphatase 2 or suppressor of cytokine signaling 3.
    Mahboubi K, Kirkiles-Smith NC, Karras J, Pober JS.
    J Biol Chem; 2003 Jul 04; 278(27):25014-23. PubMed ID: 12724316
    [Abstract] [Full Text] [Related]

  • 10. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
    Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG, Silva A, Asimakis M, Farley A, Nash AD, Metcalf D, Hilton DJ, Nicola NA, Baca M.
    Proc Natl Acad Sci U S A; 2000 Jun 06; 97(12):6493-8. PubMed ID: 10829066
    [Abstract] [Full Text] [Related]

  • 11. Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.
    Nakaoka Y, Nishida K, Fujio Y, Izumi M, Terai K, Oshima Y, Sugiyama S, Matsuda S, Koyasu S, Yamauchi-Takihara K, Hirano T, Kawase I, Hirota H.
    Circ Res; 2003 Aug 08; 93(3):221-9. PubMed ID: 12855672
    [Abstract] [Full Text] [Related]

  • 12. Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor.
    Bartoe JL, Nathanson NM.
    Brain Res Mol Brain Res; 2002 Nov 15; 107(2):108-19. PubMed ID: 12425940
    [Abstract] [Full Text] [Related]

  • 13. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
    Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M.
    Nat Med; 2002 Oct 15; 8(10):1089-97. PubMed ID: 12219085
    [Abstract] [Full Text] [Related]

  • 14. Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.
    Friederichs K, Schmitz J, Weissenbach M, Heinrich PC, Schaper F.
    Eur J Biochem; 2001 Dec 15; 268(24):6401-7. PubMed ID: 11737194
    [Abstract] [Full Text] [Related]

  • 15. Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.
    Terstegen L, Maassen BG, Radtke S, Behrmann I, Schaper F, Heinrich PC, Graeve L, Gatsios P.
    FEBS Lett; 2000 Jul 28; 478(1-2):100-4. PubMed ID: 10922477
    [Abstract] [Full Text] [Related]

  • 16. Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.
    Kim H, Baumann H.
    Mol Cell Biol; 1999 Aug 28; 19(8):5326-38. PubMed ID: 10409724
    [Abstract] [Full Text] [Related]

  • 17. Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
    Sommer U, Schmid C, Sobota RM, Lehmann U, Stevenson NJ, Johnston JA, Schaper F, Heinrich PC, Haan S.
    J Biol Chem; 2005 Sep 09; 280(36):31478-88. PubMed ID: 16000307
    [Abstract] [Full Text] [Related]

  • 18. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.
    De Souza D, Fabri LJ, Nash A, Hilton DJ, Nicola NA, Baca M.
    Biochemistry; 2002 Jul 23; 41(29):9229-36. PubMed ID: 12119038
    [Abstract] [Full Text] [Related]

  • 19. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase.
    Takahashi-Tezuka M, Yoshida Y, Fukada T, Ohtani T, Yamanaka Y, Nishida K, Nakajima K, Hibi M, Hirano T.
    Mol Cell Biol; 1998 Jul 23; 18(7):4109-17. PubMed ID: 9632795
    [Abstract] [Full Text] [Related]

  • 20. gp130-Dependent signalling pathway is not enhanced in gp130 transgenic heart after LIF stimulation.
    Tone E, Kunisada K, Kumanogoh A, Negoro S, Funamoto M, Osugi T, Kishimoto T, Yamauchi-Takihara K.
    Cytokine; 2000 Oct 23; 12(10):1512-8. PubMed ID: 11023666
    [Abstract] [Full Text] [Related]

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