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157 related items for PubMed ID: 12595632

  • 1. The G1 domain of aggrecan released from porcine articular cartilage forms stable complexes with hyaluronan/link protein.
    Yasumoto T, Bird JL, Sugimoto K, Mason RM, Bayliss MT.
    Rheumatology (Oxford); 2003 Feb; 42(2):336-42. PubMed ID: 12595632
    [Abstract] [Full Text] [Related]

  • 2. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
    Chockalingam PS, Zeng W, Morris EA, Flannery CR.
    Arthritis Rheum; 2004 Sep; 50(9):2839-48. PubMed ID: 15457452
    [Abstract] [Full Text] [Related]

  • 3. Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures.
    Munteanu SE, Ilic MZ, Handley CJ.
    Matrix Biol; 2002 Aug; 21(5):429-40. PubMed ID: 12225808
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors.
    Bonassar LJ, Sandy JD, Lark MW, Plaas AH, Frank EH, Grodzinsky AJ.
    Arch Biochem Biophys; 1997 Aug 15; 344(2):404-12. PubMed ID: 9264555
    [Abstract] [Full Text] [Related]

  • 5. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.
    Biochem J; 1999 Nov 15; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
    [Abstract] [Full Text] [Related]

  • 6. Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid.
    Ilic MZ, Mok MT, Williamson OD, Campbell MA, Hughes CE, Handley CJ.
    Arch Biochem Biophys; 1995 Sep 10; 322(1):22-30. PubMed ID: 7574678
    [Abstract] [Full Text] [Related]

  • 7. The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.
    Sztrolovics R, White RJ, Roughley PJ, Mort JS.
    Biochem J; 2002 Mar 01; 362(Pt 2):465-72. PubMed ID: 11853556
    [Abstract] [Full Text] [Related]

  • 8. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
    Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS.
    Biochem J; 1995 Feb 01; 305 ( Pt 3)(Pt 3):799-804. PubMed ID: 7531436
    [Abstract] [Full Text] [Related]

  • 9. Cartilage degradation independent of MMP/aggrecanases.
    Sugimoto K, Iizawa T, Harada H, Yamada K, Katsumata M, Takahashi M.
    Osteoarthritis Cartilage; 2004 Dec 01; 12(12):1006-14. PubMed ID: 15564068
    [Abstract] [Full Text] [Related]

  • 10. Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures.
    Munteanu SE, Ilic MZ, Handley CJ.
    Arthritis Rheum; 2000 Oct 01; 43(10):2211-8. PubMed ID: 11037880
    [Abstract] [Full Text] [Related]

  • 11. TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.
    Gendron C, Kashiwagi M, Hughes C, Caterson B, Nagase H.
    FEBS Lett; 2003 Dec 18; 555(3):431-6. PubMed ID: 14675751
    [Abstract] [Full Text] [Related]

  • 12. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
    Mercuri FA, Doege KJ, Arner EC, Pratta MA, Last K, Fosang AJ.
    J Biol Chem; 1999 Nov 05; 274(45):32387-95. PubMed ID: 10542281
    [Abstract] [Full Text] [Related]

  • 13. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW, Williams H, Hoernner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R.
    Biochem J; 1995 Apr 01; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
    [Abstract] [Full Text] [Related]

  • 14. Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
    Sztrolovics R, White RJ, Poole AR, Mort JS, Roughley PJ.
    Biochem J; 1999 May 01; 339 ( Pt 3)(Pt 3):571-7. PubMed ID: 10215595
    [Abstract] [Full Text] [Related]

  • 15. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.
    Fosang AJ, Last K, Stanton H, Weeks DB, Campbell IK, Hardingham TE, Hembry RM.
    J Biol Chem; 2000 Oct 20; 275(42):33027-37. PubMed ID: 10882746
    [Abstract] [Full Text] [Related]

  • 16. Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan.
    Vilim V, Fosang AJ.
    Biochem J; 1994 Dec 15; 304 ( Pt 3)(Pt 3):887-94. PubMed ID: 7818495
    [Abstract] [Full Text] [Related]

  • 17. Coincubation of bovine synovial or capsular tissue with cartilage generates a soluble "Aggrecanase" activity.
    Vankemmelbeke MN, Ilic MZ, Handley CJ, Knight CG, Buttle DJ.
    Biochem Biophys Res Commun; 1999 Feb 24; 255(3):686-91. PubMed ID: 10049771
    [Abstract] [Full Text] [Related]

  • 18. Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage.
    Nishida Y, D'Souza AL, Thonar EJ, Knudson W.
    Arthritis Rheum; 2000 Jun 24; 43(6):1315-26. PubMed ID: 10857790
    [Abstract] [Full Text] [Related]

  • 19. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.
    Struglics A, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LS.
    Osteoarthritis Cartilage; 2006 Feb 24; 14(2):101-13. PubMed ID: 16188468
    [Abstract] [Full Text] [Related]

  • 20. The structure of aggrecan and its turnover in cartilage.
    Hardingham TE, Fosang AJ.
    J Rheumatol Suppl; 1995 Feb 24; 43():86-90. PubMed ID: 7752148
    [Abstract] [Full Text] [Related]


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