These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

1458 related items for PubMed ID: 12634421

  • 1. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
    Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.
    Proc Natl Acad Sci U S A; 2003 Apr 01; 100(7):4162-7. PubMed ID: 12634421
    [Abstract] [Full Text] [Related]

  • 2. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
    Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.
    Am J Pathol; 2004 Apr 01; 164(4):1425-34. PubMed ID: 15039230
    [Abstract] [Full Text] [Related]

  • 3. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
    Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.
    Biochemistry; 2005 May 03; 44(17):6513-25. PubMed ID: 15850385
    [Abstract] [Full Text] [Related]

  • 4. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues.
    Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK.
    Am J Physiol Endocrinol Metab; 2019 Jan 01; 316(1):E106-E120. PubMed ID: 30422705
    [Abstract] [Full Text] [Related]

  • 5. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
    Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.
    J Neurosci; 2000 Mar 01; 20(5):1657-65. PubMed ID: 10684867
    [Abstract] [Full Text] [Related]

  • 6. Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila.
    Tsuda M, Kobayashi T, Matsuo T, Aigaki T.
    FEBS Lett; 2010 Jul 02; 584(13):2916-20. PubMed ID: 20493190
    [Abstract] [Full Text] [Related]

  • 7. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.
    Qiu WQ, Folstein MF.
    Neurobiol Aging; 2006 Feb 02; 27(2):190-8. PubMed ID: 16399206
    [Abstract] [Full Text] [Related]

  • 8. Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.
    Kawahara K, Suenobu M, Ohtsuka H, Kuniyasu A, Sugimoto Y, Nakagomi M, Fukasawa H, Shudo K, Nakayama H.
    J Alzheimers Dis; 2014 Feb 02; 42(2):587-605. PubMed ID: 24916544
    [Abstract] [Full Text] [Related]

  • 9. Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.
    Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T.
    Biochem Cell Biol; 2016 Dec 02; 94(6):534-542. PubMed ID: 27813426
    [Abstract] [Full Text] [Related]

  • 10. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
    Li H, Wu J, Zhu L, Sha L, Yang S, Wei J, Ji L, Tang X, Mao K, Cao L, Wei N, Xie W, Yang Z.
    Biosci Rep; 2018 Feb 28; 38(1):. PubMed ID: 29222348
    [Abstract] [Full Text] [Related]

  • 11. Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease.
    Zhang Y, Yin F, Liu J, Liu Z, Guo L, Xia Z, Zidichouski J.
    Neurochem Int; 2015 Oct 28; 89():7-16. PubMed ID: 25882165
    [Abstract] [Full Text] [Related]

  • 12. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.
    Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM.
    FASEB J; 2004 May 28; 18(7):902-4. PubMed ID: 15033922
    [Abstract] [Full Text] [Related]

  • 13. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.
    Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM.
    J Neurosci; 2004 Dec 08; 24(49):11120-6. PubMed ID: 15590928
    [Abstract] [Full Text] [Related]

  • 14. Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease.
    Li G, Kim C, Kim J, Yoon H, Zhou H, Kim J.
    J Alzheimers Dis; 2015 Dec 08; 46(1):109-22. PubMed ID: 25720399
    [Abstract] [Full Text] [Related]

  • 15. Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models.
    Stargardt A, Gillis J, Kamphuis W, Wiemhoefer A, Kooijman L, Raspe M, Benckhuijsen W, Drijfhout JW, Hol EM, Reits E.
    Aging Cell; 2013 Jun 08; 12(3):499-507. PubMed ID: 23534431
    [Abstract] [Full Text] [Related]

  • 16. Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease.
    Lauer AA, Mett J, Janitschke D, Thiel A, Stahlmann CP, Bachmann CM, Ritzmann F, Schrul B, Müller UC, Stein R, Riemenschneider M, Grimm HS, Hartmann T, Grimm MOW.
    Aging Cell; 2020 Nov 08; 19(11):e13264. PubMed ID: 33128835
    [Abstract] [Full Text] [Related]

  • 17. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.
    Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K.
    Neuroscience; 2018 Aug 10; 385():227-236. PubMed ID: 29932983
    [Abstract] [Full Text] [Related]

  • 18. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease.
    Del Campo M, Stargardt A, Veerhuis R, Reits E, Teunissen CE.
    Neurosci Lett; 2015 Mar 04; 589():47-51. PubMed ID: 25597881
    [Abstract] [Full Text] [Related]

  • 19. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
    Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.
    J Biol Chem; 1998 Dec 04; 273(49):32730-8. PubMed ID: 9830016
    [Abstract] [Full Text] [Related]

  • 20. Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus.
    Tang WJ.
    Trends Endocrinol Metab; 2016 Jan 04; 27(1):24-34. PubMed ID: 26651592
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 73.