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217 related items for PubMed ID: 12637985

  • 1. The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.
    Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.
    Diabetologia; 2003 Jan; 46(1):71-9. PubMed ID: 12637985
    [Abstract] [Full Text] [Related]

  • 2. Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease.
    Chargé SB, Esiri MM, Bethune CA, Hansen BC, Clark A.
    J Pathol; 1996 Aug; 179(4):443-7. PubMed ID: 8869295
    [Abstract] [Full Text] [Related]

  • 3. An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets.
    Henson MS, Buman BL, Jordan K, Rahrmann EP, Hardy RM, Johnson KH, O'Brien TD.
    Amyloid; 2006 Dec; 13(4):250-9. PubMed ID: 17107885
    [Abstract] [Full Text] [Related]

  • 4. Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation.
    Jaikaran ET, Nilsson MR, Clark A.
    Biochem J; 2004 Feb 01; 377(Pt 3):709-16. PubMed ID: 14565847
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  • 5. Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.
    Zraika S, Hull RL, Udayasankar J, Clark A, Utzschneider KM, Tong J, Gerchman F, Kahn SE.
    Diabetes; 2007 Feb 01; 56(2):304-10. PubMed ID: 17259373
    [Abstract] [Full Text] [Related]

  • 6. Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.
    Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.
    Diabetologia; 1999 Apr 01; 42(4):427-34. PubMed ID: 10230646
    [Abstract] [Full Text] [Related]

  • 7. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.
    Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S.
    J Neurochem; 2004 Aug 01; 90(4):1011-8. PubMed ID: 15287908
    [Abstract] [Full Text] [Related]

  • 8. Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.
    Andrikopoulos S, Hull RL, Verchere CB, Wang F, Wilbur SM, Wight TN, Marzban L, Kahn SE.
    Am J Physiol Endocrinol Metab; 2004 Mar 01; 286(3):E418-24. PubMed ID: 14613923
    [Abstract] [Full Text] [Related]

  • 9. Islet amyloid polypeptide in proliferating pancreatic B cells during development, hyperplasia, and neoplasia in humans and mice.
    Rindi G, Terenghi G, Westermark G, Westermark P, Moscoso G, Polak JM.
    Am J Pathol; 1991 Jun 01; 138(6):1321-34. PubMed ID: 1647136
    [Abstract] [Full Text] [Related]

  • 10. Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.
    Hull RL, Watts MR, Kodama K, Shen ZP, Utzschneider KM, Carr DB, Vidal J, Kahn SE.
    Am J Physiol Endocrinol Metab; 2005 Oct 01; 289(4):E703-9. PubMed ID: 15899941
    [Abstract] [Full Text] [Related]

  • 11. beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.
    Diabetes; 2000 Dec 01; 49(12):2056-62. PubMed ID: 11118007
    [Abstract] [Full Text] [Related]

  • 12. Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.
    de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.
    Proc Natl Acad Sci U S A; 1994 Aug 30; 91(18):8467-71. PubMed ID: 8078905
    [Abstract] [Full Text] [Related]

  • 13. [Construction of transgenic mouse system expressing human islet amyloid polypeptide (IAPP)/amylin].
    Yagui K, Kanatsuka A, Makino H.
    Nihon Rinsho; 1994 Oct 30; 52(10):2746-50. PubMed ID: 7983808
    [Abstract] [Full Text] [Related]

  • 14. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.
    Westwell-Roper C, Dai DL, Soukhatcheva G, Potter KJ, van Rooijen N, Ehses JA, Verchere CB.
    J Immunol; 2011 Sep 01; 187(5):2755-65. PubMed ID: 21813778
    [Abstract] [Full Text] [Related]

  • 15. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.
    Dolev I, Michaelson DM.
    Proc Natl Acad Sci U S A; 2004 Sep 21; 101(38):13909-14. PubMed ID: 15365176
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  • 17. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.
    Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE.
    Regul Pept; 2007 Oct 04; 143(1-3):97-103. PubMed ID: 17482289
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  • 20. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.
    Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.
    Diabetes; 2007 May 04; 56(5):1324-32. PubMed ID: 17353506
    [Abstract] [Full Text] [Related]

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