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Journal Abstract Search
240 related items for PubMed ID: 12646035
1. A comparison of physiochemical property profiles of development and marketed oral drugs. Wenlock MC, Austin RP, Barton P, Davis AM, Leeson PD. J Med Chem; 2003 Mar 27; 46(7):1250-6. PubMed ID: 12646035 [Abstract] [Full Text] [Related]
6. Lipid-based formulations for oral administration of poorly water-soluble drugs. Mu H, Holm R, Müllertz A. Int J Pharm; 2013 Aug 30; 453(1):215-24. PubMed ID: 23578826 [Abstract] [Full Text] [Related]
7. Molecular inflation, attrition and the rule of five. Leeson PD. Adv Drug Deliv Rev; 2016 Jun 01; 101():22-33. PubMed ID: 26836397 [Abstract] [Full Text] [Related]
10. Absorption classification of oral drugs based on molecular surface properties. Bergström CA, Strafford M, Lazorova L, Avdeef A, Luthman K, Artursson P. J Med Chem; 2003 Feb 13; 46(4):558-70. PubMed ID: 12570377 [Abstract] [Full Text] [Related]
11. Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties? Giordanetto F, Kihlberg J. J Med Chem; 2014 Jan 23; 57(2):278-95. PubMed ID: 24044773 [Abstract] [Full Text] [Related]
13. Quality guidelines for oral drug candidates: dose, solubility and lipophilicity. Bayliss MK, Butler J, Feldman PL, Green DV, Leeson PD, Palovich MR, Taylor AJ. Drug Discov Today; 2016 Oct 23; 21(10):1719-1727. PubMed ID: 27423371 [Abstract] [Full Text] [Related]
14. Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening. Zuegg J, Cooper MA. Curr Top Med Chem; 2012 Oct 23; 12(14):1500-13. PubMed ID: 22827520 [Abstract] [Full Text] [Related]
15. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety. Meanwell NA. Chem Res Toxicol; 2011 Sep 19; 24(9):1420-56. PubMed ID: 21790149 [Abstract] [Full Text] [Related]
17. Pharmaceutical profiling in drug discovery. Kerns EH, Di L. Drug Discov Today; 2003 Apr 01; 8(7):316-23. PubMed ID: 12654544 [Abstract] [Full Text] [Related]
18. The physicochemical challenges of designing multiple ligands. Morphy R, Rankovic Z. J Med Chem; 2006 Aug 10; 49(16):4961-70. PubMed ID: 16884308 [Abstract] [Full Text] [Related]