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543 related items for PubMed ID: 12646636

  • 1. ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region.
    Pan-Hammarström Q, Dai S, Zhao Y, van Dijk-Härd IF, Gatti RA, Børresen-Dale AL, Hammarström L.
    J Immunol; 2003 Apr 01; 170(7):3707-16. PubMed ID: 12646636
    [Abstract] [Full Text] [Related]

  • 2. Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation.
    Pan-Hammarström Q, Lähdesmäki A, Zhao Y, Du L, Zhao Z, Wen S, Ruiz-Perez VL, Dunn-Walters DK, Goodship JA, Hammarström L.
    J Exp Med; 2006 Jan 23; 203(1):99-110. PubMed ID: 16390936
    [Abstract] [Full Text] [Related]

  • 3. Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.
    Komori A, Xu Z, Wu X, Zan H, Casali P.
    Mol Immunol; 2006 Apr 23; 43(11):1817-26. PubMed ID: 16412510
    [Abstract] [Full Text] [Related]

  • 4. Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.
    Zan H, Cerutti A, Dramitinos P, Schaffer A, Li Z, Casali P.
    J Immunol; 1999 Mar 15; 162(6):3437-47. PubMed ID: 10092799
    [Abstract] [Full Text] [Related]

  • 5. Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
    Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ.
    J Exp Med; 2004 Nov 01; 200(9):1111-21. PubMed ID: 15504820
    [Abstract] [Full Text] [Related]

  • 6. What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis?
    Oppezzo P, Dighiero G.
    Curr Top Microbiol Immunol; 2005 Nov 01; 294():71-89. PubMed ID: 16323428
    [Abstract] [Full Text] [Related]

  • 7. Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line.
    Chezar I, Lobel-Lavi L, Steinitz M, Laskov R.
    Mol Immunol; 2008 Nov 01; 46(1):80-90. PubMed ID: 18718665
    [Abstract] [Full Text] [Related]

  • 8. Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.
    Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T.
    J Exp Med; 2002 Feb 18; 195(4):529-34. PubMed ID: 11854365
    [Abstract] [Full Text] [Related]

  • 9. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.
    Rooney S, Alt FW, Sekiguchi J, Manis JP.
    Proc Natl Acad Sci U S A; 2005 Feb 15; 102(7):2471-5. PubMed ID: 15699324
    [Abstract] [Full Text] [Related]

  • 10. Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation.
    Scherer F, Navarrete MA, Bertinetti-Lapatki C, Boehm J, Schmitt-Graeff A, Veelken H.
    Leuk Lymphoma; 2016 Feb 15; 57(1):151-60. PubMed ID: 25860234
    [Abstract] [Full Text] [Related]

  • 11. Alternative end joining during switch recombination in patients with ataxia-telangiectasia.
    Pan Q, Petit-Frére C, Lähdesmäki A, Gregorek H, Chrzanowska KH, Hammarström L.
    Eur J Immunol; 2002 May 15; 32(5):1300-8. PubMed ID: 11981817
    [Abstract] [Full Text] [Related]

  • 12. The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region.
    Catalan N, Selz F, Imai K, Revy P, Fischer A, Durandy A.
    J Immunol; 2003 Sep 01; 171(5):2504-9. PubMed ID: 12928399
    [Abstract] [Full Text] [Related]

  • 13. Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes.
    Duan Z, Baughn LB, Wang X, Zhang Y, Gupta V, MacCarthy T, Scharff MD, Yu G.
    Proc Natl Acad Sci U S A; 2021 Jul 20; 118(29):. PubMed ID: 34253616
    [Abstract] [Full Text] [Related]

  • 14. DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.
    Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J.
    DNA Repair (Amst); 2013 Dec 20; 12(12):1087-93. PubMed ID: 24084171
    [Abstract] [Full Text] [Related]

  • 15. Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia.
    Takada S, Weitering TJ, van Os NJH, Du L, Pico-Knijnenburg I, Kuipers TB, Mei H, Salzer E, Willemsen MAAP, Weemaes CMR, Pan-Hammarstrom Q, van der Burg M.
    J Allergy Clin Immunol; 2024 May 20; 153(5):1392-1405. PubMed ID: 38280573
    [Abstract] [Full Text] [Related]

  • 16. Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts.
    Kuzin II, Ugine GD, Wu D, Young F, Chen J, Bottaro A.
    J Immunol; 2000 Feb 01; 164(3):1451-7. PubMed ID: 10640761
    [Abstract] [Full Text] [Related]

  • 17. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.
    Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW.
    Nature; 2015 Sep 03; 525(7567):134-139. PubMed ID: 26308889
    [Abstract] [Full Text] [Related]

  • 18. Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in mu and gamma transcripts.
    Tuaillon N, Taylor LD, Lonberg N, Tucker PW, Capra JD.
    Proc Natl Acad Sci U S A; 1993 Apr 15; 90(8):3720-4. PubMed ID: 8475122
    [Abstract] [Full Text] [Related]

  • 19. A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair.
    Péron S, Pan-Hammarström Q, Imai K, Du L, Taubenheim N, Sanal O, Marodi L, Bergelin-Besançon A, Benkerrou M, de Villartay JP, Fischer A, Revy P, Durandy A.
    J Exp Med; 2007 May 14; 204(5):1207-16. PubMed ID: 17485519
    [Abstract] [Full Text] [Related]

  • 20. Most marginal zone B cells in rat express germline encoded Ig VH genes and are ligand selected.
    Dammers PM, Visser A, Popa ER, Nieuwenhuis P, Kroese FG.
    J Immunol; 2000 Dec 01; 165(11):6156-69. PubMed ID: 11086049
    [Abstract] [Full Text] [Related]

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