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278 related items for PubMed ID: 12663669

  • 1. Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis.
    Madge LA, Li JH, Choi J, Pober JS.
    J Biol Chem; 2003 Jun 06; 278(23):21295-306. PubMed ID: 12663669
    [Abstract] [Full Text] [Related]

  • 2. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.
    Panka DJ, Mano T, Suhara T, Walsh K, Mier JW.
    J Biol Chem; 2001 Mar 09; 276(10):6893-6. PubMed ID: 11145953
    [Abstract] [Full Text] [Related]

  • 3. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells.
    Madge LA, Pober JS.
    J Biol Chem; 2000 May 19; 275(20):15458-65. PubMed ID: 10748004
    [Abstract] [Full Text] [Related]

  • 4. Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells.
    Li JH, D'Alessio A, Pober JS.
    Am J Pathol; 2009 Sep 19; 175(3):1124-35. PubMed ID: 19661440
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of phosphatidylinositol-3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-alpha cytotoxicity.
    Zhang L, Himi T, Morita I, Murota S.
    Cell Death Differ; 2001 May 19; 8(5):528-36. PubMed ID: 11423913
    [Abstract] [Full Text] [Related]

  • 6. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP.
    Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K.
    J Biol Chem; 2004 Jan 09; 279(2):1513-25. PubMed ID: 14551207
    [Abstract] [Full Text] [Related]

  • 7. The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway.
    Yusta B, Boushey RP, Drucker DJ.
    J Biol Chem; 2000 Nov 10; 275(45):35345-52. PubMed ID: 10940305
    [Abstract] [Full Text] [Related]

  • 8. Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).
    Suhara T, Mano T, Oliveira BE, Walsh K.
    Circ Res; 2001 Jul 06; 89(1):13-9. PubMed ID: 11440972
    [Abstract] [Full Text] [Related]

  • 9. TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2.
    Alladina SJ, Song JH, Davidge ST, Hao C, Easton AS.
    J Vasc Res; 2005 Jul 06; 42(4):337-47. PubMed ID: 15985761
    [Abstract] [Full Text] [Related]

  • 10. Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
    Inoue A, Muranaka S, Fujita H, Kanno T, Tamai H, Utsumi K.
    Free Radic Biol Med; 2004 Oct 15; 37(8):1290-9. PubMed ID: 15451068
    [Abstract] [Full Text] [Related]

  • 11. Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism.
    Wright K, Kolios G, Westwick J, Ward SG.
    J Biol Chem; 1999 Jun 11; 274(24):17193-201. PubMed ID: 10358077
    [Abstract] [Full Text] [Related]

  • 12. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.
    Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    J Biol Chem; 2001 Oct 19; 276(42):38361-9. PubMed ID: 11461904
    [Abstract] [Full Text] [Related]

  • 13. High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway.
    Sheu ML, Ho FM, Yang RS, Chao KF, Lin WW, Lin-Shiau SY, Liu SH.
    Arterioscler Thromb Vasc Biol; 2005 Mar 19; 25(3):539-45. PubMed ID: 15653566
    [Abstract] [Full Text] [Related]

  • 14. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.
    Chen X, Thakkar H, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N, Srivastava RK.
    Oncogene; 2001 Sep 20; 20(42):6073-83. PubMed ID: 11593415
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis.
    Liu X, Shi Y, Giranda VL, Luo Y.
    Mol Cancer Ther; 2006 Mar 20; 5(3):494-501. PubMed ID: 16546963
    [Abstract] [Full Text] [Related]

  • 16. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.
    Liu H, Perlman H, Pagliari LJ, Pope RM.
    J Exp Med; 2001 Jul 16; 194(2):113-26. PubMed ID: 11457886
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice.
    Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H.
    Liver Int; 2003 Oct 16; 23(5):386-96. PubMed ID: 14708901
    [Abstract] [Full Text] [Related]

  • 18. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.
    Martelli AM, Tazzari PL, Tabellini G, Bortul R, Billi AM, Manzoli L, Ruggeri A, Conte R, Cocco L.
    Leukemia; 2003 Sep 16; 17(9):1794-805. PubMed ID: 12970779
    [Abstract] [Full Text] [Related]

  • 19. Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.
    Somervaille TC, Linch DC, Khwaja A.
    Blood; 2001 Sep 01; 98(5):1374-81. PubMed ID: 11520785
    [Abstract] [Full Text] [Related]

  • 20. Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways.
    Weston CR, Balmanno K, Chalmers C, Hadfield K, Molton SA, Ley R, Wagner EF, Cook SJ.
    Oncogene; 2003 Mar 06; 22(9):1281-93. PubMed ID: 12618753
    [Abstract] [Full Text] [Related]

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