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401 related items for PubMed ID: 12665427

  • 1. Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates.
    Kovarik Z, Radić Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P.
    Biochem J; 2003 Jul 01; 373(Pt 1):33-40. PubMed ID: 12665427
    [Abstract] [Full Text] [Related]

  • 2. Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol.
    Bosak A, Gazić I, Vinković V, Kovarik Z.
    Arch Biochem Biophys; 2008 Mar 01; 471(1):72-6. PubMed ID: 18167304
    [Abstract] [Full Text] [Related]

  • 3. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.
    Kovarik Z, Radić Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P.
    Biochemistry; 2004 Mar 23; 43(11):3222-9. PubMed ID: 15023072
    [Abstract] [Full Text] [Related]

  • 4. The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.
    Saxena A, Viragh C, Frazier DS, Kovach IM, Maxwell DM, Lockridge O, Doctor BP.
    Biochemistry; 1998 Oct 27; 37(43):15086-96. PubMed ID: 9790671
    [Abstract] [Full Text] [Related]

  • 5. Binding of the neurotoxin fasciculin 2 to the acetylcholinesterase peripheral site drastically reduces the association and dissociation rate constants for N-methylacridinium binding to the active site.
    Rosenberry TL, Rabl CR, Neumann E.
    Biochemistry; 1996 Jan 23; 35(3):685-90. PubMed ID: 8547248
    [Abstract] [Full Text] [Related]

  • 6. Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.
    Johnson JL, Cusack B, Davies MP, Fauq A, Rosenberry TL.
    Biochemistry; 2003 May 13; 42(18):5438-52. PubMed ID: 12731886
    [Abstract] [Full Text] [Related]

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  • 9. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis.
    Taylor P, Hosea NA, Tsigelny I, Radić Z, Berman HA.
    Enantiomer; 1997 May 13; 2(3-4):249-60. PubMed ID: 9676269
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  • 11. Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline.
    Kovarik Z, Radić Z, Grgas B, Skrinjarić-Spoljar M, Reiner E, Simeon-Rudolf V.
    Biochim Biophys Acta; 1999 Aug 17; 1433(1-2):261-71. PubMed ID: 10446376
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  • 13. Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.
    Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radić Z, Quinn D, Taylor P, Doctor BP.
    Protein Sci; 1994 Oct 17; 3(10):1770-8. PubMed ID: 7849595
    [Abstract] [Full Text] [Related]

  • 14. Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives.
    Grosfeld H, Barak D, Ordentlich A, Velan B, Shafferman A.
    Mol Pharmacol; 1996 Sep 17; 50(3):639-49. PubMed ID: 8794905
    [Abstract] [Full Text] [Related]

  • 15. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.
    Hosea NA, Radić Z, Tsigelny I, Berman HA, Quinn DM, Taylor P.
    Biochemistry; 1996 Aug 20; 35(33):10995-1004. PubMed ID: 8718893
    [Abstract] [Full Text] [Related]

  • 16. Chimeric human cholinesterase. Identification of interaction sites responsible for recognition of acetyl- or butyrylcholinesterase-specific ligands.
    Loewenstein Y, Gnatt A, Neville LF, Soreq H.
    J Mol Biol; 1993 Nov 20; 234(2):289-96. PubMed ID: 8230213
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  • 17. Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity.
    Vellom DC, Radić Z, Li Y, Pickering NA, Camp S, Taylor P.
    Biochemistry; 1993 Jan 12; 32(1):12-7. PubMed ID: 8418833
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  • 18. Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.
    Ashani Y, Radić Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P.
    J Biol Chem; 1995 Mar 17; 270(11):6370-80. PubMed ID: 7890775
    [Abstract] [Full Text] [Related]

  • 19. Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
    Szegletes T, Mallender WD, Rosenberry TL.
    Biochemistry; 1998 Mar 24; 37(12):4206-16. PubMed ID: 9521743
    [Abstract] [Full Text] [Related]

  • 20. Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases.
    Hosea NA, Berman HA, Taylor P.
    Biochemistry; 1995 Sep 12; 34(36):11528-36. PubMed ID: 7547883
    [Abstract] [Full Text] [Related]

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