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Journal Abstract Search

299 related items for PubMed ID: 12666166

  • 1. Mechanistic insights into oxidosqualene cyclizations through homology modeling.
    Schulz-Gasch T, Stahl M.
    J Comput Chem; 2003 Apr 30; 24(6):741-53. PubMed ID: 12666166
    [Abstract] [Full Text] [Related]

  • 2. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
    Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A.
    Nature; 2004 Nov 04; 432(7013):118-22. PubMed ID: 15525992
    [Abstract] [Full Text] [Related]

  • 3. Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships.
    Wu TK, Chang CH, Liu YT, Wang TT.
    Chem Rec; 2008 Nov 04; 8(5):302-25. PubMed ID: 18956480
    [Abstract] [Full Text] [Related]

  • 4. The triterpene cyclase protein family: a systematic analysis.
    Racolta S, Juhl PB, Sirim D, Pleiss J.
    Proteins; 2012 Aug 04; 80(8):2009-19. PubMed ID: 22488823
    [Abstract] [Full Text] [Related]

  • 5. The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling.
    Dang T, Abe I, Zheng YF, Prestwich GD.
    Chem Biol; 1999 Jun 04; 6(6):333-41. PubMed ID: 10375539
    [Abstract] [Full Text] [Related]

  • 6. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.
    Wendt KU, Lenhart A, Schulz GE.
    J Mol Biol; 1999 Feb 12; 286(1):175-87. PubMed ID: 9931258
    [Abstract] [Full Text] [Related]

  • 7. Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
    Wu TK, Liu YT, Chiu FH, Chang CH.
    Org Lett; 2006 Oct 12; 8(21):4691-4. PubMed ID: 17020279
    [Abstract] [Full Text] [Related]

  • 8. Squalene-hopene cyclases.
    Siedenburg G, Jendrossek D.
    Appl Environ Microbiol; 2011 Jun 12; 77(12):3905-15. PubMed ID: 21531832
    [Abstract] [Full Text] [Related]

  • 9. Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies.
    Oliaro-Bosso S, Schulz-Gasch T, Taramino S, Scaldaferri M, Viola F, Balliano G.
    Biochem Soc Trans; 2005 Nov 12; 33(Pt 5):1202-5. PubMed ID: 16246081
    [Abstract] [Full Text] [Related]

  • 10. Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: sequence analysis, expression and functional characterization.
    Ghimire GP, Oh TJ, Lee HC, Sohng JK.
    Biotechnol Lett; 2009 Apr 12; 31(4):565-9. PubMed ID: 19116691
    [Abstract] [Full Text] [Related]

  • 11. Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene.
    Hoshino T, Shimizu K, Sato T.
    Angew Chem Int Ed Engl; 2004 Dec 10; 43(48):6700-3. PubMed ID: 15593147
    [No Abstract] [Full Text] [Related]

  • 12. Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases.
    Rocco F, Bosso SO, Viola F, Milla P, Roma G, Grossi G, Ceruti M.
    Lipids; 2003 Mar 10; 38(3):201-7. PubMed ID: 12784859
    [Abstract] [Full Text] [Related]

  • 13. Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases.
    Ceruti M, Balliano G, Rocco F, Milla P, Arpicco S, Cattel L, Viola F.
    Lipids; 2001 Jun 10; 36(6):629-36. PubMed ID: 11485168
    [Abstract] [Full Text] [Related]

  • 14. Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.
    Wu TK, Yu MT, Liu YT, Chang CH, Wang HJ, Diau EW.
    Org Lett; 2006 Mar 30; 8(7):1319-22. PubMed ID: 16562881
    [Abstract] [Full Text] [Related]

  • 15. Alteration of the substrate's prefolded conformation and cyclization stereochemistry of oxidosqualene-lanosterol cyclase of Saccharomyces cerevisiae by substitution at phenylalanine 699.
    Wu TK, Chang CH, Wen HY, Liu YT, Li WH, Wang TT, Shie WS.
    Org Lett; 2010 Feb 05; 12(3):500-3. PubMed ID: 20055456
    [Abstract] [Full Text] [Related]

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  • 18. Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase.
    Lodeiro S, Schulz-Gasch T, Matsuda SP.
    J Am Chem Soc; 2005 Oct 19; 127(41):14132-3. PubMed ID: 16218577
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.
    Stach D, Zheng YF, Perez AL, Oehlschlager AC, Abe I, Prestwich GD, Hartman PG.
    J Med Chem; 1997 Jan 17; 40(2):201-9. PubMed ID: 9003518
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