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Journal Abstract Search

114 related items for PubMed ID: 12668020

  • 1. Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.
    Tomczuk B, Lu T, Soll RM, Fedde C, Wang A, Murphy L, Crysler C, Dasgupta M, Eisennagel S, Spurlino J, Bone R.
    Bioorg Med Chem Lett; 2003 Apr 17; 13(8):1495-8. PubMed ID: 12668020
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  • 2. Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.
    Soll RM, Lu T, Tomczuk B, Illig CR, Fedde C, Eisennagel S, Bone R, Murphy L, Spurlino J, Salemme FR.
    Bioorg Med Chem Lett; 2000 Jan 03; 10(1):1-4. PubMed ID: 10636229
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  • 6. Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors.
    Rewinkel JB, Lucas H, Smit MJ, Noach AB, van Dinther TG, Rood AM, Jenneboer AJ, van Boeckel CA.
    Bioorg Med Chem Lett; 1999 Oct 04; 9(19):2837-42. PubMed ID: 10522702
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  • 7. Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.
    Adang AE, de Man AP, Vogel GM, Grootenhuis PD, Smit MJ, Peters CA, Visser A, Rewinkel JB, van Dinther T, Lucas H, Kelder J, van Aelst S, Meuleman DG, van Boeckel CA.
    J Med Chem; 2002 Sep 26; 45(20):4419-32. PubMed ID: 12238922
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  • 9. Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.
    Boatman PD, Ogbu CO, Eguchi M, Kim HO, Nakanishi H, Cao B, Shea JP, Kahn M.
    J Med Chem; 1999 Apr 22; 42(8):1367-75. PubMed ID: 10212122
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  • 10. Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
    Levell J, Astles P, Eastwood P, Cairns J, Houille O, Aldous S, Merriman G, Whiteley B, Pribish J, Czekaj M, Liang G, Maignan S, Guilloteau JP, Dupuy A, Davidson J, Harrison T, Morley A, Watson S, Fenton G, McCarthy C, Romano J, Mathew R, Engers D, Gardyan M, Sides K, Kwong J, Tsay J, Rebello S, Shen L, Wang J, Luo Y, Giardino O, Lim HK, Smith K, Pauls H.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2859-72. PubMed ID: 15781396
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  • 12. Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor.
    Oh YS, Yun M, Hwang SY, Hong S, Shin Y, Lee K, Yoon KH, Yoo YJ, Kim DS, Lee SH, Lee YH, Park HD, Lee CH, Lee SK, Kim S.
    Bioorg Med Chem Lett; 1998 Mar 17; 8(6):631-4. PubMed ID: 9871573
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  • 13. Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.
    Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD.
    Bioorg Med Chem Lett; 1998 Dec 01; 8(23):3409-14. PubMed ID: 9873743
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  • 14. Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.
    Costanzo MJ, Maryanoff BE, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Kauffman JA, Lewis JM, Krishnan R, Tulinsky A.
    J Med Chem; 1996 Aug 02; 39(16):3039-43. PubMed ID: 8759623
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  • 17. [On inhibition of the coagulation enzyme thrombin by benzamidine derivatives].
    Markwardt F, Walsmann P.
    Experientia; 1968 Jan 15; 24(1):25-6. PubMed ID: 5637604
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  • 19. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
    Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G.
    J Mol Biol; 2009 Aug 21; 391(3):552-64. PubMed ID: 19520086
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  • 20. Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.
    Feng DM, Gardell SJ, Lewis SD, Bock MG, Chen Z, Freidinger RM, Naylor-Olsen AM, Ramjit HG, Woltmann R, Baskin EP, Lynch JJ, Lucas R, Shafer JA, Dancheck KB, Chen IW, Mao SS, Krueger JA, Hare TR, Mulichak AM, Vacca JP.
    J Med Chem; 1997 Nov 07; 40(23):3726-33. PubMed ID: 9371237
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