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120 related items for PubMed ID: 12686496

  • 1. UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes.
    Ghaoui R, Sallustio BC, Burcham PC, Fontaine FR.
    Chem Biol Interact; 2003 May 06; 145(2):201-11. PubMed ID: 12686496
    [Abstract] [Full Text] [Related]

  • 2. Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways.
    Southwood HT, DeGraaf YC, Mackenzie PI, Miners JO, Burcham PC, Sallustio BC.
    Chem Res Toxicol; 2007 Oct 06; 20(10):1520-7. PubMed ID: 17880178
    [Abstract] [Full Text] [Related]

  • 3. Bioactivation of carboxylic acid compounds by UDP-Glucuronosyltransferases to DNA-damaging intermediates: role of glycoxidation and oxidative stress in genotoxicity.
    Sallustio BC, Degraaf YC, Weekley JS, Burcham PC.
    Chem Res Toxicol; 2006 May 06; 19(5):683-91. PubMed ID: 16696571
    [Abstract] [Full Text] [Related]

  • 4. Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
    Koga T, Fujiwara R, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2011 Jan 06; 39(1):54-60. PubMed ID: 20926620
    [Abstract] [Full Text] [Related]

  • 5. Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: a novel role for phase-II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones?
    Sallustio BC, Harkin LA, Mann MC, Krivickas SJ, Burcham PC.
    Toxicol Appl Pharmacol; 1997 Dec 06; 147(2):459-64. PubMed ID: 9439741
    [Abstract] [Full Text] [Related]

  • 6. Evaluation of in situ generated valproyl 1-O-β-acyl glucuronide in valproic acid toxicity in sandwich-cultured rat hepatocytes.
    Surendradoss J, Chang TK, Abbott FS.
    Drug Metab Dispos; 2014 Nov 06; 42(11):1834-42. PubMed ID: 25147275
    [Abstract] [Full Text] [Related]

  • 7. Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.
    Grillo MP, Hua F, Knutson CG, Ware JA, Li C.
    Chem Res Toxicol; 2003 Nov 06; 16(11):1410-7. PubMed ID: 14615966
    [Abstract] [Full Text] [Related]

  • 8. Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat.
    Odum J, Orton TC.
    Biochem Pharmacol; 1983 Dec 01; 32(23):3565-9. PubMed ID: 6418177
    [Abstract] [Full Text] [Related]

  • 9. Oral contraceptives stimulate the excretion of clofibric acid glucuronide in women and female rats.
    Liu HF, Magdalou J, Nicolas A, Lafaurie C, Siest G.
    Gen Pharmacol; 1991 Dec 01; 22(2):393-7. PubMed ID: 1905251
    [Abstract] [Full Text] [Related]

  • 10. Hepatic disposition of electrophilic acyl glucuronide conjugates.
    Sallustio BC, Sabordo L, Evans AM, Nation RL.
    Curr Drug Metab; 2000 Sep 01; 1(2):163-80. PubMed ID: 11465081
    [Abstract] [Full Text] [Related]

  • 11. New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation.
    Gunduz M, Argikar UA, Cirello AL, Dumouchel JL.
    Drug Metab Lett; 2018 Sep 01; 12(2):84-92. PubMed ID: 29886840
    [Abstract] [Full Text] [Related]

  • 12. Comparative study of clofibric acid and bilirubin glucuronidation in human liver microsomes.
    Dragacci S, Hamar-Hansen C, Fournel-Gigleux S, Lafaurie C, Magdalou J, Siest G.
    Biochem Pharmacol; 1987 Nov 15; 36(22):3923-7. PubMed ID: 3120730
    [Abstract] [Full Text] [Related]

  • 13. Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?
    Liu HF, Vincent-Viry M, Galteau MM, Guéguen R, Magdalou J, Nicolas A, Leroy P, Siest G.
    Eur J Clin Pharmacol; 1991 Nov 15; 41(2):153-9. PubMed ID: 1743248
    [Abstract] [Full Text] [Related]

  • 14. Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro.
    Malfatti MA, Felton JS.
    Chem Res Toxicol; 2004 Aug 15; 17(8):1137-44. PubMed ID: 15310245
    [Abstract] [Full Text] [Related]

  • 15. Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes.
    Jinno N, Tagashira M, Tsurui K, Yamada S.
    Xenobiotica; 2014 Aug 15; 44(8):677-86. PubMed ID: 24575896
    [Abstract] [Full Text] [Related]

  • 16. The analysis of [14C]clofibric acid glucuronide and [14C]clofibric acid in plasma and urine using high-performance liquid chromatography.
    Meffin PJ, Zilm DM.
    J Chromatogr; 1983 Nov 11; 278(1):101-8. PubMed ID: 6662867
    [Abstract] [Full Text] [Related]

  • 17. Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes.
    Dong JQ, Smith PC.
    Drug Metab Dispos; 2009 Dec 11; 37(12):2314-22. PubMed ID: 19773537
    [Abstract] [Full Text] [Related]

  • 18. Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions.
    Ritter JK.
    Chem Biol Interact; 2000 Dec 01; 129(1-2):171-93. PubMed ID: 11154740
    [Abstract] [Full Text] [Related]

  • 19. In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases.
    Tong Z, Li H, Goljer I, McConnell O, Chandrasekaran A.
    Drug Metab Dispos; 2007 Dec 01; 35(12):2203-10. PubMed ID: 17875670
    [Abstract] [Full Text] [Related]

  • 20. A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
    Kazmi F, Barbara JE, Yerino P, Parkinson A.
    Drug Metab Dispos; 2015 Apr 01; 43(4):523-33. PubMed ID: 25595597
    [Abstract] [Full Text] [Related]

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