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Journal Abstract Search

189 related items for PubMed ID: 12711602

  • 1. Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Jun 06; 278(23):20449-52. PubMed ID: 12711602
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  • 2. Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.
    Loo TW, Bartlett MC, Clarke DM.
    Biochem J; 2006 Jun 15; 396(3):537-45. PubMed ID: 16492138
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  • 3. Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Dec 12; 278(50):50136-41. PubMed ID: 14522974
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  • 4. Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.
    Loo TW, Bartlett MC, Clarke DM.
    Biochem J; 2006 Oct 15; 399(2):351-9. PubMed ID: 16813563
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  • 5. The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.
    Loo TW, Bartlett MC, Clarke DM.
    Biochemistry; 2004 Sep 28; 43(38):12081-9. PubMed ID: 15379547
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  • 7. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Oct 10; 278(41):39706-10. PubMed ID: 12909621
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  • 8. Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane.
    Loo TW, Clarke DM.
    J Biol Chem; 2000 Dec 15; 275(50):39272-8. PubMed ID: 11013259
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  • 10. Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Jan 17; 278(3):1575-8. PubMed ID: 12421806
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  • 13. Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.
    Loo TW, Clarke DM.
    Biochem Biophys Res Commun; 2017 Jul 08; 488(4):573-577. PubMed ID: 28533092
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  • 14. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Apr 18; 278(16):13603-6. PubMed ID: 12609990
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  • 15. Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.
    Loo TW, Clarke DM.
    J Biol Chem; 1995 Sep 15; 270(37):21449-52. PubMed ID: 7665554
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  • 18. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
    Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV.
    PLoS One; 2013 Sep 15; 8(12):e82463. PubMed ID: 24349290
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