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Journal Abstract Search

189 related items for PubMed ID: 12711602

  • 1. Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Jun 06; 278(23):20449-52. PubMed ID: 12711602
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  • 3. Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Dec 12; 278(50):50136-41. PubMed ID: 14522974
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  • 11. Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane.
    Loo TW, Clarke DM.
    J Biol Chem; 1999 Dec 10; 274(50):35388-92. PubMed ID: 10585407
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  • 12. Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2004 Feb 27; 279(9):7692-7. PubMed ID: 14670948
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  • 13. Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.
    Loo TW, Clarke DM.
    Biochem Biophys Res Commun; 2017 Jul 08; 488(4):573-577. PubMed ID: 28533092
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  • 14. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.
    Loo TW, Bartlett MC, Clarke DM.
    J Biol Chem; 2003 Apr 18; 278(16):13603-6. PubMed ID: 12609990
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  • 17. Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.
    Loo TW, Clarke DM.
    J Biol Chem; 2000 Jun 30; 275(26):19435-8. PubMed ID: 10806188
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  • 18. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
    Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV.
    PLoS One; 2013 Jun 30; 8(12):e82463. PubMed ID: 24349290
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  • 20. Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model.
    Garrigos M, Mir LM, Orlowski S.
    Eur J Biochem; 1997 Mar 01; 244(2):664-73. PubMed ID: 9119038
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