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183 related items for PubMed ID: 12711631

  • 1. A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells.
    Matsuoka Y, Nagahara Y, Ikekita M, Shinomiya T.
    Br J Pharmacol; 2003 Apr; 138(7):1303-12. PubMed ID: 12711631
    [Abstract] [Full Text] [Related]

  • 2. FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
    Sonoda Y, Yamamoto D, Sakurai S, Hasegawa M, Aizu-Yokota E, Momoi T, Kasahara T.
    Biochem Biophys Res Commun; 2001 Feb 23; 281(2):282-8. PubMed ID: 11181042
    [Abstract] [Full Text] [Related]

  • 3. Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival.
    Chandrasekher G, Sailaja D.
    Invest Ophthalmol Vis Sci; 2004 Oct 23; 45(10):3577-88. PubMed ID: 15452065
    [Abstract] [Full Text] [Related]

  • 4. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
    Lee TK, Man K, Ho JW, Sun CK, Ng KT, Wang XH, Wong YC, Ng IO, Xu R, Fan ST.
    Carcinogenesis; 2004 Dec 23; 25(12):2397-405. PubMed ID: 15297371
    [Abstract] [Full Text] [Related]

  • 5. Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C.
    Huang C, Li J, Ke Q, Leonard SS, Jiang BH, Zhong XS, Costa M, Castranova V, Shi X.
    Cancer Res; 2002 Oct 15; 62(20):5689-97. PubMed ID: 12384526
    [Abstract] [Full Text] [Related]

  • 6. Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase.
    Boudreau RT, Conrad DM, Hoskin DW.
    Cell Signal; 2007 Jan 15; 19(1):139-51. PubMed ID: 16844342
    [Abstract] [Full Text] [Related]

  • 7. Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.
    Nagahara Y, Matsuoka Y, Saito K, Ikekita M, Higuchi S, Shinomiya T.
    Jpn J Cancer Res; 2001 Jun 15; 92(6):680-7. PubMed ID: 11429058
    [Abstract] [Full Text] [Related]

  • 8. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
    Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, Catley L, Mitsiades CS, Richardson PG, Albert R, Brinkmann V, Chauhan D, Anderson KC.
    Cancer Res; 2005 Aug 15; 65(16):7478-84. PubMed ID: 16103102
    [Abstract] [Full Text] [Related]

  • 9. Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts.
    Gao A, Liu B, Shi X, Jia X, Ye M, Jiao S, You B, Huang C.
    Toxicol Lett; 2007 Apr 05; 170(1):30-41. PubMed ID: 17383120
    [Abstract] [Full Text] [Related]

  • 10. T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2.
    Nagahara Y, Ikekita M, Shinomiya T.
    Br J Pharmacol; 2002 Dec 05; 137(7):953-62. PubMed ID: 12429567
    [Abstract] [Full Text] [Related]

  • 11. Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway.
    Matsuda S, Minowa A, Suzuki S, Koyasu S.
    J Immunol; 1999 Mar 15; 162(6):3321-6. PubMed ID: 10092785
    [Abstract] [Full Text] [Related]

  • 12. IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.
    Fujiwara H, Yamakuni T, Ueno M, Ishizuka M, Shinkawa T, Isobe T, Ohizumi Y.
    J Pharmacol Exp Ther; 2004 Sep 15; 310(3):1288-95. PubMed ID: 15161934
    [Abstract] [Full Text] [Related]

  • 13. Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway.
    Markova B, Albers C, Breitenbuecher F, Melo JV, Brümmendorf TH, Heidel F, Lipka D, Duyster J, Huber C, Fischer T.
    Oncogene; 2010 Feb 04; 29(5):739-51. PubMed ID: 19881535
    [Abstract] [Full Text] [Related]

  • 14. Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.
    Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, Schäfers M, von Wnuck Lipinski K, Jankowski J, Jankowski V, Chun J, Zidek W, Van der Giet M.
    Circ Res; 2005 Apr 29; 96(8):913-20. PubMed ID: 15802614
    [Abstract] [Full Text] [Related]

  • 15. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.
    Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, Takahara S.
    Anticancer Res; 2003 Apr 29; 23(4):3183-93. PubMed ID: 12926052
    [Abstract] [Full Text] [Related]

  • 16. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
    Azuma H, Takahara S, Horie S, Muto S, Otsuki Y, Katsuoka Y.
    J Urol; 2003 Jun 29; 169(6):2372-7. PubMed ID: 12771800
    [Abstract] [Full Text] [Related]

  • 17. IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase.
    Kuemmerle JF.
    Am J Physiol Gastrointest Liver Physiol; 2003 Mar 29; 284(3):G411-22. PubMed ID: 12444011
    [Abstract] [Full Text] [Related]

  • 18. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells.
    Asselin E, Mills GB, Tsang BK.
    Cancer Res; 2001 Mar 01; 61(5):1862-8. PubMed ID: 11280739
    [Abstract] [Full Text] [Related]

  • 19. Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.
    Potteck H, Nieuwenhuis B, Lüth A, van der Giet M, Kleuser B.
    Cell Physiol Biochem; 2010 Mar 01; 26(1):67-78. PubMed ID: 20502006
    [Abstract] [Full Text] [Related]

  • 20. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
    Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, Katsuoka Y.
    Anticancer Res; 2007 Mar 01; 27(1A):75-88. PubMed ID: 17352219
    [Abstract] [Full Text] [Related]

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