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Journal Abstract Search

212 related items for PubMed ID: 12733905

  • 1. Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase.
    Yin Y, Lu H, Khosla C, Cane DE.
    J Am Chem Soc; 2003 May 14; 125(19):5671-6. PubMed ID: 12733905
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  • 2. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase.
    Lu H, Tsai SC, Khosla C, Cane DE.
    Biochemistry; 2002 Oct 22; 41(42):12590-7. PubMed ID: 12379101
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  • 3. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.
    Wu J, Zaleski TJ, Valenzano C, Khosla C, Cane DE.
    J Am Chem Soc; 2005 Dec 14; 127(49):17393-404. PubMed ID: 16332089
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  • 5. Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase.
    He W, Wu J, Khosla C, Cane DE.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):391-4. PubMed ID: 16249083
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  • 7. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
    Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C.
    J Am Chem Soc; 2003 May 07; 125(18):5366-74. PubMed ID: 12720450
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  • 9. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Lau J, Fu H, Cane DE, Khosla C.
    Biochemistry; 1999 Feb 02; 38(5):1643-51. PubMed ID: 9931032
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  • 11. Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase.
    Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH.
    J Am Chem Soc; 2003 Oct 15; 125(41):12551-7. PubMed ID: 14531700
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  • 12. 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.
    Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE.
    Biochemistry; 1996 Dec 03; 35(48):15244-8. PubMed ID: 8952473
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  • 13. Mechanisms of molecular recognition in the pikromycin polyketide synthase.
    Chen S, Xue Y, Sherman DH, Reynolds KA.
    Chem Biol; 2000 Dec 03; 7(12):907-18. PubMed ID: 11137814
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  • 15. Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli.
    Murli S, Piagentini M, McDaniel R, Hutchinson CR.
    Biochemistry; 2004 Dec 21; 43(50):15884-90. PubMed ID: 15595843
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  • 16. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.
    Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C.
    Biochemistry; 1997 Feb 18; 36(7):1846-51. PubMed ID: 9048569
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  • 17. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
    Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R.
    Biochemistry; 2003 Jan 14; 42(1):72-9. PubMed ID: 12515540
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  • 18. Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis.
    Jacobsen JR, Cane DE, Khosla C.
    Biochemistry; 1998 Apr 07; 37(14):4928-34. PubMed ID: 9538011
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  • 19. The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.
    Weissman KJ, Timoney M, Bycroft M, Grice P, Hanefeld U, Staunton J, Leadlay PF.
    Biochemistry; 1997 Nov 11; 36(45):13849-55. PubMed ID: 9374862
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  • 20. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase.
    Kumar P, Koppisch AT, Cane DE, Khosla C.
    J Am Chem Soc; 2003 Nov 26; 125(47):14307-12. PubMed ID: 14624579
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