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129 related items for PubMed ID: 12734588

  • 1. The Metabolic Inhibition Model Which Predicts the Intestinal Absorbability and Metabolizability of Drug: Theory and Experiment.
    Mizuma T, Awazu S.
    Biol Proced Online; 1998 May 14; 1():32-39. PubMed ID: 12734588
    [Abstract] [Full Text] [Related]

  • 2. Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors.
    Mizuma T, Ohta K, Koyanagi A, Awazu S.
    J Pharm Sci; 1996 Aug 14; 85(8):854-7. PubMed ID: 8863276
    [Abstract] [Full Text] [Related]

  • 3. Intestinal transport and metabolism of glucose-conjugated kyotorphin and cyclic kyotorphin: metabolic degradation is crucial to intestinal absorption of peptide drugs.
    Mizuma T, Koyanagi A, Awazu S.
    Biochim Biophys Acta; 2000 Jun 01; 1475(1):90-8. PubMed ID: 10806343
    [Abstract] [Full Text] [Related]

  • 4. Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: rate-limiting factor in intestinal absorption of peptide as drug.
    Mizuma T, Koyanagi A, Awazu S.
    Biochim Biophys Acta; 1997 Apr 17; 1335(1-2):111-9. PubMed ID: 9133647
    [Abstract] [Full Text] [Related]

  • 5. Intestinal absorption and analgesic activity of aminopeptidase-resistant cellobiose-coupled leucine enkephalinamide.
    Mizuma T, Ohta K, Awazu S.
    Biopharm Drug Dispos; 1998 Dec 17; 19(9):605-10. PubMed ID: 9872343
    [Abstract] [Full Text] [Related]

  • 6. Preference of Peyer's patches to jejunal epithelium for intestinal absorption of oligopeptides, tyrosylglycylglycine and D-kyotorphin.
    Haseto S, Mizuma T, Ouchi H, Isoda T, Hayashi M, Awazu S.
    Biol Pharm Bull; 1997 Sep 17; 20(9):1024-5. PubMed ID: 9331991
    [Abstract] [Full Text] [Related]

  • 7. Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats.
    Mizuma T, Awazu S.
    Biochim Biophys Acta; 1998 Oct 23; 1425(2):398-404. PubMed ID: 9795255
    [Abstract] [Full Text] [Related]

  • 8. Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.
    Tam D, Tirona RG, Pang KS.
    Drug Metab Dispos; 2003 Apr 23; 31(4):373-83. PubMed ID: 12642462
    [Abstract] [Full Text] [Related]

  • 9. Peripherally active analgesia of aminopeptidase-resistant sugar-coupled leucine enkephalin.
    Mizuma T, Ohta K, Awazu S.
    Res Commun Mol Pathol Pharmacol; 1997 Jan 23; 95(1):83-91. PubMed ID: 9055351
    [Abstract] [Full Text] [Related]

  • 10. Hydrolysis of leucine enkephalin in the nasal cavity of the rat--a possible factor in the low bioavailability of nasally administered peptides.
    Hussain A, Faraj J, Aramaki Y, Truelove JE.
    Biochem Biophys Res Commun; 1985 Dec 31; 133(3):923-8. PubMed ID: 4084310
    [Abstract] [Full Text] [Related]

  • 11. Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form.
    Mizuma T, Masubuchi S, Awazu S.
    J Pharm Pharmacol; 1997 Nov 31; 49(11):1067-71. PubMed ID: 9401939
    [Abstract] [Full Text] [Related]

  • 12. Intestinal absorption of stable cyclic dipeptides by the oligopeptide transporter in rat.
    Mizuma T, Masubuchi S, Awazu S.
    J Pharm Pharmacol; 1998 Feb 31; 50(2):167-72. PubMed ID: 9530984
    [Abstract] [Full Text] [Related]

  • 13. Effect of dietary fat on fat absorption and concomitant plasma and tissue fat composition in a rat model of short bowel syndrome.
    Sukhotnik I, Mor-Vaknin N, Drongowski RA, Coran AG, Harmon CM.
    Pediatr Surg Int; 2004 Mar 31; 20(3):185-91. PubMed ID: 15045516
    [Abstract] [Full Text] [Related]

  • 14. Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues.
    Friedman DI, Amidon GL.
    Pharm Res; 1991 Jan 31; 8(1):93-6. PubMed ID: 2014216
    [Abstract] [Full Text] [Related]

  • 15. Inhibitory effects of the analgesic neuropeptides kyotorphin and neo-kyotorphin on enkephalin-degrading enzymes from monkey brain.
    Hazato T, Kase R, Ueda H, Takagi H, Katayama T.
    Biochem Int; 1986 Mar 31; 12(3):379-83. PubMed ID: 3011001
    [Abstract] [Full Text] [Related]

  • 16. Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines.
    Suresh D, Srinivasan K.
    Food Chem Toxicol; 2007 Aug 31; 45(8):1437-42. PubMed ID: 17524539
    [Abstract] [Full Text] [Related]

  • 17. Degradation of kyotorphin by a purified membrane-bound-aminopeptidase from monkey brain: potentiation of kyotorphin-induced analgesia by a highly effective inhibitor, bestatin.
    Ueda H, Ming G, Hazato T, Katayama T, Takagi H.
    Life Sci; 1985 May 13; 36(19):1865-71. PubMed ID: 3990513
    [Abstract] [Full Text] [Related]

  • 18. Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene.
    Neyama H, Hamada Y, Tsukahara R, Narita M, Tsukamoto K, Ueda H.
    Peptides; 2018 Sep 13; 107():10-16. PubMed ID: 30040980
    [Abstract] [Full Text] [Related]

  • 19. Gastrointestinal absorption of peptide drug: quantitative evaluation of the degradation and the permeation of metkephamid in rat small intestine.
    Taki Y, Sakane T, Nadai T, Sezaki H, Amidon GL, Langguth P, Yamashita S.
    J Pharmacol Exp Ther; 1995 Jul 13; 274(1):373-7. PubMed ID: 7616421
    [Abstract] [Full Text] [Related]

  • 20. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
    Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT.
    Pharm Res; 1999 Jan 13; 16(1):16-23. PubMed ID: 9950273
    [Abstract] [Full Text] [Related]

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