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213 related items for PubMed ID: 12739951

  • 1. Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases.
    Senten K, Daniëls L, Van der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K.
    J Comb Chem; 2003; 5(3):336-44. PubMed ID: 12739951
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors.
    Belyaev A, Zhang X, Augustyns K, Lambeir AM, De Meester I, Vedernikova I, Scharpé S, Haemers A.
    J Med Chem; 1999 Mar 25; 42(6):1041-52. PubMed ID: 10090787
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases.
    Senten K, Van der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K.
    J Med Chem; 2003 Nov 06; 46(23):5005-14. PubMed ID: 14584950
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, kinetic evaluation, and utilization of a biotinylated dipeptide proline diphenyl phosphonate for the disclosure of dipeptidyl peptidase IV-like serine proteases.
    Gilmore BF, Carson L, McShane LL, Quinn D, Coulter WA, Walker B.
    Biochem Biophys Res Commun; 2006 Aug 18; 347(1):373-9. PubMed ID: 16824486
    [Abstract] [Full Text] [Related]

  • 5. Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.
    Van der Veken P, De Meester I, Dubois V, Soroka A, Van Goethem S, Maes MB, Brandt I, Lambeir AM, Chen X, Haemers A, Scharpé S, Augustyns K.
    Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4154-8. PubMed ID: 18556199
    [Abstract] [Full Text] [Related]

  • 6. Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.
    Lu IL, Lee SJ, Tsu H, Wu SY, Kao KH, Chien CH, Chang YY, Chen YS, Cheng JH, Chang CN, Chen TW, Chang SP, Chen X, Jiaang WT.
    Bioorg Med Chem Lett; 2005 Jul 01; 15(13):3271-5. PubMed ID: 15927466
    [Abstract] [Full Text] [Related]

  • 7. Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors.
    Van Goethem S, Van der Veken P, Dubois V, Soroka A, Lambeir AM, Chen X, Haemers A, Scharpé S, De Meester I, Augustyns K.
    Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4159-62. PubMed ID: 18556198
    [Abstract] [Full Text] [Related]

  • 8. Dipeptidyl peptidase IV: development, design, synthesis and biological evaluation of inhibitors.
    Borloo M, De Meester I.
    Verh K Acad Geneeskd Belg; 1994 Jul 15; 56(1):57-88. PubMed ID: 7911611
    [Abstract] [Full Text] [Related]

  • 9. Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha).
    Gilmore BF, Lynas JF, Scott CJ, McGoohan C, Martin L, Walker B.
    Biochem Biophys Res Commun; 2006 Jul 28; 346(2):436-46. PubMed ID: 16769036
    [Abstract] [Full Text] [Related]

  • 10. 4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.
    Wu W, Liu Y, Milo LJ, Shu Y, Zhao P, Li Y, Woznica I, Yu G, Sanford DG, Zhou Y, Poplawski SE, Connolly BA, Sudmeier JL, Bachovchin WW, Lai JH.
    Bioorg Med Chem Lett; 2012 Sep 01; 22(17):5536-40. PubMed ID: 22853995
    [Abstract] [Full Text] [Related]

  • 11. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
    Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA.
    Biochem J; 2003 Apr 15; 371(Pt 2):525-32. PubMed ID: 12529175
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines.
    Soroka A, Van der Veken P, De Meester I, Lambeir AM, Maes MB, Scharpé S, Haemers A, Augustyns K.
    Bioorg Med Chem Lett; 2006 Sep 15; 16(18):4777-9. PubMed ID: 16844373
    [Abstract] [Full Text] [Related]

  • 13. Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors.
    Senten K, Van Der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K.
    J Med Chem; 2004 May 20; 47(11):2906-16. PubMed ID: 15139769
    [Abstract] [Full Text] [Related]

  • 14. 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
    Tsu H, Chen X, Chen CT, Lee SJ, Chang CN, Kao KH, Coumar MS, Yeh YT, Chien CH, Wang HS, Lin KT, Chang YY, Wu SH, Chen YS, Lu IL, Wu SY, Tsai TY, Chen WC, Hsieh HP, Chao YS, Jiaang WT.
    J Med Chem; 2006 Jan 12; 49(1):373-80. PubMed ID: 16392822
    [Abstract] [Full Text] [Related]

  • 15. Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases.
    Van der Veken P, Senten K, Kertèsz I, De Meester I, Lambeir AM, Maes MB, Scharpé S, Haemers A, Augustyns K.
    J Med Chem; 2005 Mar 24; 48(6):1768-80. PubMed ID: 15771423
    [Abstract] [Full Text] [Related]

  • 16. The metal-binding motif of dipeptidyl peptidase III directly influences the enzyme activity in the copper derivative of dipeptidyl peptidase III.
    Hirose J, Kamigakiuchi H, Iwamoto H, Fujii H, Nakai M, Takenaka M, Kataoka R, Sugahara M, Yamamoto S, Fukasawa KM.
    Arch Biochem Biophys; 2004 Nov 01; 431(1):1-8. PubMed ID: 15464720
    [Abstract] [Full Text] [Related]

  • 17. Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.
    Magnin DR, Robl JA, Sulsky RB, Augeri DJ, Huang Y, Simpkins LM, Taunk PC, Betebenner DA, Robertson JG, Abboa-Offei BE, Wang A, Cap M, Xin L, Tao L, Sitkoff DF, Malley MF, Gougoutas JZ, Khanna A, Huang Q, Han SP, Parker RA, Hamann LG.
    J Med Chem; 2004 May 06; 47(10):2587-98. PubMed ID: 15115400
    [Abstract] [Full Text] [Related]

  • 18. Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides.
    Coutts SJ, Kelly TA, Snow RJ, Kennedy CA, Barton RW, Adams J, Krolikowski DA, Freeman DM, Campbell SJ, Ksiazek JF, Bachovchin WW.
    J Med Chem; 1996 May 10; 39(10):2087-94. PubMed ID: 8642568
    [Abstract] [Full Text] [Related]

  • 19. Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV.
    Lambeir AM, Borloo M, De Meester I, Belyaev A, Augustyns K, Hendriks D, Scharpé S, Haemers A.
    Biochim Biophys Acta; 1996 May 21; 1290(1):76-82. PubMed ID: 8645710
    [Abstract] [Full Text] [Related]

  • 20. Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.
    Meadows SA, Edosada CY, Mayeda M, Tran T, Quan C, Raab H, Wiesmann C, Wolf BB.
    Biochemistry; 2007 Apr 17; 46(15):4598-605. PubMed ID: 17381073
    [Abstract] [Full Text] [Related]

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