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Journal Abstract Search

432 related items for PubMed ID: 12746310

  • 21. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
    Chockalingam PS, Zeng W, Morris EA, Flannery CR.
    Arthritis Rheum; 2004 Sep; 50(9):2839-48. PubMed ID: 15457452
    [Abstract] [Full Text] [Related]

  • 22. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
    Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD.
    Osteoarthritis Cartilage; 1998 May; 6(3):214-28. PubMed ID: 9682788
    [Abstract] [Full Text] [Related]

  • 23. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E.
    Matrix Biol; 2000 Nov; 19(6):533-43. PubMed ID: 11068207
    [Abstract] [Full Text] [Related]

  • 24. The cleavage of biglycan by aggrecanases.
    Melching LI, Fisher WD, Lee ER, Mort JS, Roughley PJ.
    Osteoarthritis Cartilage; 2006 Nov; 14(11):1147-54. PubMed ID: 16806997
    [Abstract] [Full Text] [Related]

  • 25. The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
    Koshy PJ, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, Clark IM, Cawston TE.
    Arthritis Rheum; 2002 Apr; 46(4):961-7. PubMed ID: 11953973
    [Abstract] [Full Text] [Related]

  • 26. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
    Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ.
    Nature; 2005 Mar 31; 434(7033):648-52. PubMed ID: 15800625
    [Abstract] [Full Text] [Related]

  • 27. IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage.
    Flannery CR, Little CB, Hughes CE, Curtis CL, Caterson B, Jones SA.
    Matrix Biol; 2000 Nov 31; 19(6):549-53. PubMed ID: 11068209
    [Abstract] [Full Text] [Related]

  • 28. Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes.
    Sylvester J, Liacini A, Li WQ, Zafarullah M.
    Cell Signal; 2004 Apr 31; 16(4):469-76. PubMed ID: 14709335
    [Abstract] [Full Text] [Related]

  • 29. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW, Williams H, Hoernner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R.
    Biochem J; 1995 Apr 01; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
    [Abstract] [Full Text] [Related]

  • 30. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E.
    Biochem J; 1998 Jul 01; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
    [Abstract] [Full Text] [Related]

  • 31. Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.
    Pratta MA, Su JL, Leesnitzer MA, Struglics A, Larsson S, Lohmander LS, Kumar S.
    Osteoarthritis Cartilage; 2006 Jul 01; 14(7):702-13. PubMed ID: 16549371
    [Abstract] [Full Text] [Related]

  • 32. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
    Kashiwagi M, Tortorella M, Nagase H, Brew K.
    J Biol Chem; 2001 Apr 20; 276(16):12501-4. PubMed ID: 11278243
    [Abstract] [Full Text] [Related]

  • 33. Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression.
    Pattoli MA, MacMaster JF, Gregor KR, Burke JR.
    J Pharmacol Exp Ther; 2005 Oct 20; 315(1):382-8. PubMed ID: 16009742
    [Abstract] [Full Text] [Related]

  • 34. Effects of glucocorticoids and interleukin-1 beta on expression and activity of aggrecanases in equine chondrocytes.
    Busschers E, Holt JP, Richardson DW.
    Am J Vet Res; 2010 Feb 20; 71(2):176-85. PubMed ID: 20113225
    [Abstract] [Full Text] [Related]

  • 35. "Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.
    Buttle DJ, Fowles A, Ilic MZ, Handley CJ.
    Mol Pathol; 1997 Jun 20; 50(3):153-9. PubMed ID: 9292151
    [Abstract] [Full Text] [Related]

  • 36. Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system.
    Powell AJ, Little CB, Hughes CE.
    Arthritis Rheum; 2007 Sep 20; 56(9):3010-9. PubMed ID: 17763444
    [Abstract] [Full Text] [Related]

  • 37. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
    Clements KM, Price JS, Chambers MG, Visco DM, Poole AR, Mason RM.
    Arthritis Rheum; 2003 Dec 20; 48(12):3452-63. PubMed ID: 14673996
    [Abstract] [Full Text] [Related]

  • 38. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.
    Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.
    J Biol Chem; 2005 May 13; 280(19):19185-95. PubMed ID: 15760903
    [Abstract] [Full Text] [Related]

  • 39. Effects of X irradiation on metabolism of proteoglycans.
    Jikko A, Hiranuma H, Iwamoto M, Kato Y, Okada Y, Fuchihata H.
    Radiat Res; 1996 Jul 13; 146(1):93-9. PubMed ID: 8677304
    [Abstract] [Full Text] [Related]

  • 40. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
    Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R, Rockwell A, Yang F, Duke JL, Solomon K, George H, Bruckner R, Nagase H, Itoh Y, Ellis DM, Ross H, Wiswall BH, Murphy K, Hillman MC, Hollis GF, Newton RC, Magolda RL, Trzaskos JM, Arner EC.
    Science; 1999 Jun 04; 284(5420):1664-6. PubMed ID: 10356395
    [Abstract] [Full Text] [Related]

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