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142 related items for PubMed ID: 12746452

  • 1. cFLIP-L inhibits p38 MAPK activation: an additional anti-apoptotic mechanism in bile acid-mediated apoptosis.
    Grambihler A, Higuchi H, Bronk SF, Gores GJ.
    J Biol Chem; 2003 Jul 18; 278(29):26831-7. PubMed ID: 12746452
    [Abstract] [Full Text] [Related]

  • 2. Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis.
    Higuchi H, Yoon JH, Grambihler A, Werneburg N, Bronk SF, Gores GJ.
    J Biol Chem; 2003 Jan 03; 278(1):454-61. PubMed ID: 12407100
    [Abstract] [Full Text] [Related]

  • 3. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
    Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, Dent P.
    Mol Biol Cell; 2001 Sep 03; 12(9):2629-45. PubMed ID: 11553704
    [Abstract] [Full Text] [Related]

  • 4. Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation.
    Bhattacharyya A, Pathak S, Basak C, Law S, Kundu M, Basu J.
    J Biol Chem; 2003 Jul 18; 278(29):26517-25. PubMed ID: 12724324
    [Abstract] [Full Text] [Related]

  • 5. Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.
    Gehrke N, Nagel M, Straub BK, Wörns MA, Schuchmann M, Galle PR, Schattenberg JM.
    Am J Physiol Gastrointest Liver Physiol; 2018 Mar 01; 314(3):G319-G333. PubMed ID: 29191940
    [Abstract] [Full Text] [Related]

  • 6. Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex.
    Kavuri SM, Geserick P, Berg D, Dimitrova DP, Feoktistova M, Siegmund D, Gollnick H, Neumann M, Wajant H, Leverkus M.
    J Biol Chem; 2011 May 13; 286(19):16631-46. PubMed ID: 21454681
    [Abstract] [Full Text] [Related]

  • 7. Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.
    Ahn JH, Park SM, Cho HS, Lee MS, Yoon JB, Vilcek J, Lee TH.
    J Biol Chem; 2001 Dec 14; 276(50):47100-6. PubMed ID: 11600497
    [Abstract] [Full Text] [Related]

  • 8. Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.
    Siegmund D, Mauri D, Peters N, Juo P, Thome M, Reichwein M, Blenis J, Scheurich P, Tschopp J, Wajant H.
    J Biol Chem; 2001 Aug 31; 276(35):32585-90. PubMed ID: 11384965
    [Abstract] [Full Text] [Related]

  • 9. Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis.
    Cottin V, Van Linden AA, Riches DW.
    J Biol Chem; 2001 May 18; 276(20):17252-60. PubMed ID: 11278725
    [Abstract] [Full Text] [Related]

  • 10. Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.
    Shimada K, Nakamura M, Ishida E, Kishi M, Yonehara S, Konishi N.
    Jpn J Cancer Res; 2002 Oct 18; 93(10):1164-74. PubMed ID: 12417047
    [Abstract] [Full Text] [Related]

  • 11. cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.
    Guicciardi ME, Bronk SF, Werneburg NW, Gores GJ.
    Am J Physiol Gastrointest Liver Physiol; 2007 May 18; 292(5):G1337-46. PubMed ID: 17272514
    [Abstract] [Full Text] [Related]

  • 12. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.
    Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P.
    Mol Cell Biol; 2003 May 18; 23(9):3052-66. PubMed ID: 12697808
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.
    Davies CC, Mason J, Wakelam MJ, Young LS, Eliopoulos AG.
    J Biol Chem; 2004 Jan 09; 279(2):1010-9. PubMed ID: 14581487
    [Abstract] [Full Text] [Related]

  • 14. Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma.
    Okano H, Shiraki K, Inoue H, Kawakita T, Yamanaka T, Deguchi M, Sugimoto K, Sakai T, Ohmori S, Fujikawa K, Murata K, Nakano T.
    Lab Invest; 2003 Jul 09; 83(7):1033-43. PubMed ID: 12861043
    [Abstract] [Full Text] [Related]

  • 15. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
    Park MT, Choi JA, Kim MJ, Um HD, Bae S, Kang CM, Cho CK, Kang S, Chung HY, Lee YS, Lee SJ.
    J Biol Chem; 2003 Dec 12; 278(50):50624-34. PubMed ID: 14522966
    [Abstract] [Full Text] [Related]

  • 16. NF-kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha-related apoptosis-inducing ligand (TRAIL).
    Pawlowski JE, Nesterov A, Scheinman RI, Johnson TR, Kraft AS.
    Anticancer Res; 2000 Dec 12; 20(6B):4243-55. PubMed ID: 11205254
    [Abstract] [Full Text] [Related]

  • 17. p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).
    Grethe S, Ares MP, Andersson T, Pörn-Ares MI.
    Exp Cell Res; 2004 Aug 15; 298(2):632-42. PubMed ID: 15265709
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD).
    Wajant H, Haas E, Schwenzer R, Muhlenbeck F, Kreuz S, Schubert G, Grell M, Smith C, Scheurich P.
    J Biol Chem; 2000 Aug 11; 275(32):24357-66. PubMed ID: 10823821
    [Abstract] [Full Text] [Related]

  • 19. Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression.
    Yeh JH, Hsu SC, Han SH, Lai MZ.
    J Exp Med; 1998 Nov 16; 188(10):1795-802. PubMed ID: 9815257
    [Abstract] [Full Text] [Related]

  • 20. p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling.
    Tourian L, Zhao H, Srikant CB.
    J Cell Sci; 2004 Dec 15; 117(Pt 26):6459-71. PubMed ID: 15572410
    [Abstract] [Full Text] [Related]

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