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103 related items for PubMed ID: 12749886

  • 1. Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).
    Costantino G, Macchiarulo A, Entrena-Guadix A, Camaioni E, Pellicciari R.
    Bioorg Med Chem Lett; 2003 Jun 02; 13(11):1865-8. PubMed ID: 12749886
    [Abstract] [Full Text] [Related]

  • 2. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
    Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A.
    J Med Chem; 2004 Aug 26; 47(18):4559-69. PubMed ID: 15317466
    [Abstract] [Full Text] [Related]

  • 3. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
    Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B.
    Mol Endocrinol; 2003 Feb 26; 17(2):259-72. PubMed ID: 12554753
    [Abstract] [Full Text] [Related]

  • 4. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.
    Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour BM, Sabatino G, Russo G, Castellani D, Willson TM, Pruzanski M, Pellicciari R, Morelli A.
    J Pharmacol Exp Ther; 2005 May 26; 313(2):604-12. PubMed ID: 15644430
    [Abstract] [Full Text] [Related]

  • 5. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
    Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM.
    J Med Chem; 2002 Aug 15; 45(17):3569-72. PubMed ID: 12166927
    [Abstract] [Full Text] [Related]

  • 6. Bile acids: natural ligands for an orphan nuclear receptor.
    Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM.
    Science; 1999 May 21; 284(5418):1365-8. PubMed ID: 10334993
    [Abstract] [Full Text] [Related]

  • 7. The farnesoid X receptor: a novel drug target?
    Claudel T, Sturm E, Kuipers F, Staels B.
    Expert Opin Investig Drugs; 2004 Sep 21; 13(9):1135-48. PubMed ID: 15330745
    [Abstract] [Full Text] [Related]

  • 8. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
    Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM.
    Mol Cell; 2003 Apr 21; 11(4):1079-92. PubMed ID: 12718892
    [Abstract] [Full Text] [Related]

  • 9. Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.
    Li YT, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D.
    Arterioscler Thromb Vasc Biol; 2007 Dec 21; 27(12):2606-11. PubMed ID: 18029909
    [Abstract] [Full Text] [Related]

  • 10. Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
    Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B.
    Mol Endocrinol; 2008 Nov 21; 22(11):2433-47. PubMed ID: 18755856
    [Abstract] [Full Text] [Related]

  • 11. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
    Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA.
    Am J Physiol Gastrointest Liver Physiol; 2006 Mar 21; 290(3):G476-85. PubMed ID: 16269519
    [Abstract] [Full Text] [Related]

  • 12. Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.
    Fujino T, Une M, Imanaka T, Inoue K, Nishimaki-Mogami T.
    J Lipid Res; 2004 Jan 21; 45(1):132-8. PubMed ID: 13130122
    [Abstract] [Full Text] [Related]

  • 13. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
    Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S.
    J Med Chem; 2006 Jul 13; 49(14):4208-15. PubMed ID: 16821780
    [Abstract] [Full Text] [Related]

  • 14. T0901317 is a dual LXR/FXR agonist.
    Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, Burris TP.
    Mol Genet Metab; 2004 Jul 13; 83(1-2):184-7. PubMed ID: 15464433
    [Abstract] [Full Text] [Related]

  • 15. The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.
    Kanaya E, Shiraki T, Jingami H.
    Biochem J; 2004 Sep 15; 382(Pt 3):913-21. PubMed ID: 15202934
    [Abstract] [Full Text] [Related]

  • 16. Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
    Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ, Kullak-Ublick GA.
    Gastroenterology; 2002 Jun 15; 122(7):1954-66. PubMed ID: 12055601
    [Abstract] [Full Text] [Related]

  • 17. In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association.
    Fujino T, Sato Y, Une M, Kanayasu-Toyoda T, Yamaguchi T, Shudo K, Inoue K, Nishimaki-Mogami T.
    J Steroid Biochem Mol Biol; 2003 Dec 15; 87(4-5):247-52. PubMed ID: 14698205
    [Abstract] [Full Text] [Related]

  • 18. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.
    Wang H, Chen J, Hollister K, Sowers LC, Forman BM.
    Mol Cell; 1999 May 15; 3(5):543-53. PubMed ID: 10360171
    [Abstract] [Full Text] [Related]

  • 19. Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.
    Ho PP, Steinman L.
    Proc Natl Acad Sci U S A; 2016 Feb 09; 113(6):1600-5. PubMed ID: 26811456
    [Abstract] [Full Text] [Related]

  • 20. Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter.
    Shen H, Zhang Y, Ding H, Wang X, Chen L, Jiang H, Shen X.
    Cell Physiol Biochem; 2008 Feb 09; 22(1-4):1-14. PubMed ID: 18769028
    [Abstract] [Full Text] [Related]

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