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Journal Abstract Search

247 related items for PubMed ID: 12755606

  • 1. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA.
    Biochemistry; 2003 May 27; 42(20):6043-56. PubMed ID: 12755606
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3577-85. PubMed ID: 15848770
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  • 4. Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
    Klein C, Chen P, Arevalo JH, Stura EA, Marolewski A, Warren MS, Benkovic SJ, Wilson IA.
    J Mol Biol; 1995 May 26; 249(1):153-75. PubMed ID: 7776369
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  • 5. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586
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  • 7. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3593-9. PubMed ID: 15848772
    [Abstract] [Full Text] [Related]

  • 8. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
    Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA.
    Biochemistry; 2001 Nov 13; 40(45):13538-47. PubMed ID: 11695901
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  • 9. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4511-21. PubMed ID: 13129587
    [Abstract] [Full Text] [Related]

  • 10. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.
    Connelly S, DeMartino JK, Boger DL, Wilson IA.
    Biochemistry; 2013 Jul 30; 52(30):5133-44. PubMed ID: 23869564
    [Abstract] [Full Text] [Related]

  • 11. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
    Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA.
    Biochemistry; 2002 Dec 03; 41(48):14206-15. PubMed ID: 12450384
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  • 12. New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
    Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA.
    Biochemistry; 1999 Dec 21; 38(51):16783-93. PubMed ID: 10606510
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  • 14. X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli.
    Wang W, Kappock TJ, Stubbe J, Ealick SE.
    Biochemistry; 1998 Nov 10; 37(45):15647-62. PubMed ID: 9843369
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  • 15. A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
    Su Y, Yamashita MM, Greasley SE, Mullen CA, Shim JH, Jennings PA, Benkovic SJ, Wilson IA.
    J Mol Biol; 1998 Aug 21; 281(3):485-99. PubMed ID: 9698564
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  • 19. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 21; 5(9):1847-52. PubMed ID: 9354240
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