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Journal Abstract Search

175 related items for PubMed ID: 12767280

  • 1. Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.
    Haidar S, Ehmer PB, Barassin S, Batzl-Hartmann C, Hartmann RW.
    J Steroid Biochem Mol Biol; 2003 Apr; 84(5):555-62. PubMed ID: 12767280
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  • 2. Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
    Barrie SE, Potter GA, Goddard PM, Haynes BP, Dowsett M, Jarman M.
    J Steroid Biochem Mol Biol; 1994 Sep; 50(5-6):267-73. PubMed ID: 7918112
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  • 3. Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).
    Hartmann RW, Hector M, Wachall BG, Palusczak A, Palzer M, Huch V, Veith M.
    J Med Chem; 2000 Nov 16; 43(23):4437-45. PubMed ID: 11087568
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  • 4. Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats.
    Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Yoden T, Okada M, Fujikura T, Akaza H, Shikama H.
    Prostate; 1998 Sep 15; 37(1):10-8. PubMed ID: 9721064
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  • 7. Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.
    Nnane IP, Kato K, Liu Y, Lu Q, Wang X, Ling YZ, Brodie A.
    Cancer Res; 1998 Sep 01; 58(17):3826-32. PubMed ID: 9731491
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  • 8. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
    Njar VC, Kato K, Nnane IP, Grigoryev DN, Long BJ, Brodie AM.
    J Med Chem; 1998 Mar 12; 41(6):902-12. PubMed ID: 9526564
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  • 9. The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.
    Jarman M, Barrie SE, Llera JM.
    J Med Chem; 1998 Dec 31; 41(27):5375-81. PubMed ID: 9876107
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  • 10. Inhibition of androgen synthesis in human testicular and prostatic microsomes and in male rats by novel steroidal compounds.
    Nnane IP, Kato K, Liu Y, Long BJ, Lu Q, Wang X, Ling YZ, Brodie A.
    Endocrinology; 1999 Jun 31; 140(6):2891-7. PubMed ID: 10342882
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  • 11. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.
    J Steroid Biochem Mol Biol; 2008 Jul 31; 111(1-2):117-27. PubMed ID: 18620055
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  • 12. 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
    Ling YZ, Li JS, Liu Y, Kato K, Klus GT, Brodie A.
    J Med Chem; 1997 Sep 26; 40(20):3297-304. PubMed ID: 9379450
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  • 19. Imidazole substituted biphenyls: a new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer.
    Wachall BG, Hector M, Zhuang Y, Hartmann RW.
    Bioorg Med Chem; 1999 Sep 26; 7(9):1913-24. PubMed ID: 10530940
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  • 20. 4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase.
    Li J, Li Y, Son C, Banks P, Brodie A.
    J Steroid Biochem Mol Biol; 1992 May 26; 42(3-4):313-20. PubMed ID: 1606043
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