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Journal Abstract Search

212 related items for PubMed ID: 12801220

  • 1. Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.
    Sandanayaka VP, Prashad AS, Yang Y, Williamson RT, Lin YI, Mansour TS.
    J Med Chem; 2003 Jun 19; 46(13):2569-71. PubMed ID: 12801220
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.
    Venkatesan AM, Gu Y, Dos Santos O, Abe T, Agarwal A, Yang Y, Petersen PJ, Weiss WJ, Mansour TS, Nukaga M, Hujer AM, Bonomo RA, Knox JR.
    J Med Chem; 2004 Dec 16; 47(26):6556-68. PubMed ID: 15588091
    [Abstract] [Full Text] [Related]

  • 3. Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.
    Weston GS, Blázquez J, Baquero F, Shoichet BK.
    J Med Chem; 1998 Nov 05; 41(23):4577-86. PubMed ID: 9804697
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
    Richter HG, Angehrn P, Hubschwerlen C, Kania M, Page MG, Specklin JL, Winkler FK.
    J Med Chem; 1996 Sep 13; 39(19):3712-22. PubMed ID: 8809160
    [Abstract] [Full Text] [Related]

  • 5. Pharmacodynamic study of beta-lactams alone and in combination with beta-lactamase inhibitors against Pseudomonas aeruginosa possessing an inducible beta-lactamase.
    Li C, Nicolau DP, Lister PD, Quintiliani R, Nightingale CH.
    J Antimicrob Chemother; 2004 Feb 13; 53(2):297-304. PubMed ID: 14729755
    [Abstract] [Full Text] [Related]

  • 6. Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.
    Hubschwerlen C, Angehrn P, Gubernator K, Page MG, Specklin JL.
    J Med Chem; 1998 Oct 08; 41(21):3972-5. PubMed ID: 9767634
    [Abstract] [Full Text] [Related]

  • 7. Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta-lactamase inhibition.
    Bethel CR, Hujer AM, Helfand MS, Bonomo RA.
    FEMS Microbiol Lett; 2004 May 01; 234(1):99-103. PubMed ID: 15109726
    [Abstract] [Full Text] [Related]

  • 8. Cyclobutanone analogues of beta-lactams revisited: insights into conformational requirements for inhibition of serine- and metallo-beta-lactamases.
    Johnson JW, Gretes M, Goodfellow VJ, Marrone L, Heynen ML, Strynadka NC, Dmitrienko GI.
    J Am Chem Soc; 2010 Mar 03; 132(8):2558-60. PubMed ID: 20141132
    [Abstract] [Full Text] [Related]

  • 9. 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.
    Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Ado M, Tsuyoshi T, Dos Santos O, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Weiss WJ, Shlaes DM, Mansour TS.
    Bioorg Med Chem; 2008 Feb 15; 16(4):1890-902. PubMed ID: 18061461
    [Abstract] [Full Text] [Related]

  • 10. A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases.
    Perilli M, Franceschini N, Bonfiglio G, Segatore B, Stefani S, Nicoletti G, Perez MM, Bianchi C, Zollo A, Amicosante G.
    J Enzyme Inhib; 2000 Feb 15; 15(1):1-10. PubMed ID: 10850951
    [Abstract] [Full Text] [Related]

  • 11. Nanomolar inhibitors of AmpC beta-lactamase.
    Morandi F, Caselli E, Morandi S, Focia PJ, Blázquez J, Shoichet BK, Prati F.
    J Am Chem Soc; 2003 Jan 22; 125(3):685-95. PubMed ID: 12526668
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of penam sulfones as inhibitors of beta-lactamases.
    Phillips OA, Reddy AV, Setti EL, Spevak P, Czajkowski DP, Atwal H, Salama S, Micetich RG, Maiti SN.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2847-58. PubMed ID: 15781395
    [Abstract] [Full Text] [Related]

  • 13. 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
    Plantan I, Selic L, Mesar T, Anderluh PS, Oblak M, Prezelj A, Hesse L, Andrejasic M, Vilar M, Turk D, Kocijan A, Prevec T, Vilfan G, Kocjan D, Copar A, Urleb U, Solmajer T.
    J Med Chem; 2007 Aug 23; 50(17):4113-21. PubMed ID: 17665896
    [Abstract] [Full Text] [Related]

  • 14. Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
    Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Ado M, Tsuyoshi T, Dos Santos O, Gu Y, Sum FW, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Kumagai T, Weiss WJ, Shlaes DM, Knox JR, Mansour TS.
    J Med Chem; 2006 Jul 27; 49(15):4623-37. PubMed ID: 16854068
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and antimicrobial evaluation of 2 beta-chloromethyl-6 beta-carbamoylmethyl-penam-1,1-dioxide-3-carboxylic acid.
    Gaviraghi G, Perboni A, Tamburini B, Xerri L, Salvatori A, Spadoni G, Tarzia G.
    Farmaco; 1996 Jul 27; 51(7):535-8. PubMed ID: 8765676
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines.
    Arumugam N, Periyasami G, Raghunathan R, Kamalraj S, Muthumary J.
    Eur J Med Chem; 2011 Feb 27; 46(2):600-7. PubMed ID: 21177001
    [Abstract] [Full Text] [Related]

  • 17. Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
    Tan Q, Ogawa AM, Raghoobar SL, Wisniewski D, Colwell L, Park YW, Young K, Hermes JD, Dininno FP, Hammond ML.
    Bioorg Med Chem Lett; 2011 Jul 15; 21(14):4363-5. PubMed ID: 21664132
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.
    Xia Y, Cao K, Zhou Y, Alley MR, Rock F, Mohan M, Meewan M, Baker SJ, Lux S, Ding CZ, Jia G, Kully M, Plattner JJ.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2533-6. PubMed ID: 21392987
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediate.
    Nukaga M, Abe T, Venkatesan AM, Mansour TS, Bonomo RA, Knox JR.
    Biochemistry; 2003 Nov 18; 42(45):13152-9. PubMed ID: 14609325
    [Abstract] [Full Text] [Related]

  • 20. Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design.
    Usher KC, Blaszczak LC, Weston GS, Shoichet BK, Remington SJ.
    Biochemistry; 1998 Nov 17; 37(46):16082-92. PubMed ID: 9819201
    [Abstract] [Full Text] [Related]

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