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944 related items for PubMed ID: 12817006

  • 1. TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex.
    Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D.
    J Immunol; 2003 Jul 01; 171(1):257-66. PubMed ID: 12817006
    [Abstract] [Full Text] [Related]

  • 2. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
    Schaper F, Gendo C, Eck M, Schmitz J, Grimm C, Anhuf D, Kerr IM, Heinrich PC.
    Biochem J; 1998 Nov 01; 335 ( Pt 3)(Pt 3):557-65. PubMed ID: 9794795
    [Abstract] [Full Text] [Related]

  • 3. Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
    Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F.
    J Immunol; 2000 Sep 01; 165(5):2535-43. PubMed ID: 10946280
    [Abstract] [Full Text] [Related]

  • 4. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
    Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F.
    J Biol Chem; 2003 Jan 03; 278(1):661-71. PubMed ID: 12403768
    [Abstract] [Full Text] [Related]

  • 5. Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.
    Kim H, Baumann H.
    Mol Cell Biol; 1999 Aug 03; 19(8):5326-38. PubMed ID: 10409724
    [Abstract] [Full Text] [Related]

  • 6. Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.
    Fairlie WD, De Souza D, Nicola NA, Baca M.
    Biochem J; 2003 Jun 01; 372(Pt 2):495-502. PubMed ID: 12593670
    [Abstract] [Full Text] [Related]

  • 7. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
    Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Müller-Newen G, Heinrich PC, Schaper F.
    Biochem J; 2004 Mar 01; 378(Pt 2):449-60. PubMed ID: 14611646
    [Abstract] [Full Text] [Related]

  • 8. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
    Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F.
    J Biol Chem; 2000 Apr 28; 275(17):12848-56. PubMed ID: 10777583
    [Abstract] [Full Text] [Related]

  • 9. Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.
    Terstegen L, Maassen BG, Radtke S, Behrmann I, Schaper F, Heinrich PC, Graeve L, Gatsios P.
    FEBS Lett; 2000 Jul 28; 478(1-2):100-4. PubMed ID: 10922477
    [Abstract] [Full Text] [Related]

  • 10. Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.
    Friederichs K, Schmitz J, Weissenbach M, Heinrich PC, Schaper F.
    Eur J Biochem; 2001 Dec 28; 268(24):6401-7. PubMed ID: 11737194
    [Abstract] [Full Text] [Related]

  • 11. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
    Niemand C, Nimmesgern A, Haan S, Fischer P, Schaper F, Rossaint R, Heinrich PC, Müller-Newen G.
    J Immunol; 2003 Mar 15; 170(6):3263-72. PubMed ID: 12626585
    [Abstract] [Full Text] [Related]

  • 12. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
    Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M.
    Nat Med; 2002 Oct 15; 8(10):1089-97. PubMed ID: 12219085
    [Abstract] [Full Text] [Related]

  • 13. Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells.
    Kim H, Hawley TS, Hawley RG, Baumann H.
    Mol Cell Biol; 1998 Mar 15; 18(3):1525-33. PubMed ID: 9488469
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.
    Ahmed ST, Ivashkiv LB.
    J Immunol; 2000 Nov 01; 165(9):5227-37. PubMed ID: 11046056
    [Abstract] [Full Text] [Related]

  • 15. Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.
    Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G.
    J Immunol; 1997 May 01; 158(9):4097-103. PubMed ID: 9126968
    [Abstract] [Full Text] [Related]

  • 16. Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.
    Nakaoka Y, Nishida K, Fujio Y, Izumi M, Terai K, Oshima Y, Sugiyama S, Matsuda S, Koyasu S, Yamauchi-Takihara K, Hirano T, Kawase I, Hirota H.
    Circ Res; 2003 Aug 08; 93(3):221-9. PubMed ID: 12855672
    [Abstract] [Full Text] [Related]

  • 17. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
    Schmitz J, Dahmen H, Grimm C, Gendo C, Müller-Newen G, Heinrich PC, Schaper F.
    J Immunol; 2000 Jan 15; 164(2):848-54. PubMed ID: 10623831
    [Abstract] [Full Text] [Related]

  • 18. Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.
    Novotny-Diermayr V, Lin B, Gu L, Cao X.
    J Biol Chem; 2005 Apr 01; 280(13):12747-57. PubMed ID: 15677447
    [Abstract] [Full Text] [Related]

  • 19. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
    Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L.
    Biochem J; 1998 Sep 01; 334 ( Pt 2)(Pt 2):297-314. PubMed ID: 9716487
    [Abstract] [Full Text] [Related]

  • 20. Desensitization of signaling by oncostatin M in human vascular cells involves cytoplasmic Tyr residue 759 in gp130 but is not mediated by either Src homology 2 domain-containing tyrosine phosphatase 2 or suppressor of cytokine signaling 3.
    Mahboubi K, Kirkiles-Smith NC, Karras J, Pober JS.
    J Biol Chem; 2003 Jul 04; 278(27):25014-23. PubMed ID: 12724316
    [Abstract] [Full Text] [Related]

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