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Journal Abstract Search

245 related items for PubMed ID: 12819349

  • 1. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.
    Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW.
    Proc Natl Acad Sci U S A; 2003 Jul 08; 100(14):8146-50. PubMed ID: 12819349
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  • 2. Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.
    Shin H, Gennadios HA, Whittington DA, Christianson DW.
    Bioorg Med Chem; 2007 Apr 01; 15(7):2617-23. PubMed ID: 17296300
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  • 3. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W.
    Bioorg Med Chem Lett; 2013 Apr 15; 23(8):2362-7. PubMed ID: 23499237
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  • 4. Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 12; 45(49):14573-81. PubMed ID: 17144651
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  • 6. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
    Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR.
    J Biol Chem; 2000 Apr 14; 275(15):11002-9. PubMed ID: 10753902
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  • 7. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.
    Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P.
    Nat Struct Biol; 2003 Aug 14; 10(8):645-51. PubMed ID: 12833153
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  • 9. Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
    Barb AW, Zhou P.
    Curr Pharm Biotechnol; 2008 Feb 14; 9(1):9-15. PubMed ID: 18289052
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  • 12. Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 26; 45(51):15240-8. PubMed ID: 17176046
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  • 16. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 .
    Cole KE, Gattis SG, Angell HD, Fierke CA, Christianson DW.
    Biochemistry; 2011 Jan 18; 50(2):258-65. PubMed ID: 21171638
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  • 17. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
    McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J.
    Biochemistry; 2005 Feb 01; 44(4):1106-13. PubMed ID: 15667204
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  • 18. Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity.
    Hernick M, Gattis SG, Penner-Hahn JE, Fierke CA.
    Biochemistry; 2010 Mar 16; 49(10):2246-55. PubMed ID: 20136146
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  • 19. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.
    Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM.
    J Med Chem; 2002 Sep 12; 45(19):4359-70. PubMed ID: 12213077
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  • 20. Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.
    Gao N, McLeod SM, Hajec L, Olivier NB, Lahiri SD, Bryan Prince D, Thresher J, Ross PL, Whiteaker JD, Doig P, Li AH, Hill PJ, Cornebise M, Reck F, Hale MR.
    Protein Expr Purif; 2014 Dec 12; 104():57-64. PubMed ID: 25240855
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